-
公开(公告)号:DE58907930D1
公开(公告)日:1994-07-28
申请号:DE58907930
申请日:1989-05-30
Applicant: HOECHST AG
Inventor: BONIN WERNER , HABERMANN PAUL , TRIPIER DOMINIQUE , WOEHNER ELISABET
IPC: A61K38/55 , A61K35/56 , A61K38/00 , A61P7/02 , C07K1/14 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/44 , C07K14/81 , C07K15/08 , A61K37/02
Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.
-
82.
公开(公告)号:ZA9301774B
公开(公告)日:1993-09-30
申请号:ZA9301774
申请日:1993-03-12
Applicant: HOECHST AG
Inventor: SCHAPER WOLFGANG , PREUSS RAINER , BRAUN PETER , SALBECK GERHARD , KNAUF WERNER , SACHSE BURKHARD , WALTERSDORFER ANNA , LUEMMEN PETER , BONIN WERNER , KERN MANFRED
IPC: A01N43/54 , A01N43/90 , A01P3/00 , A01P7/02 , A01P7/04 , C07D239/34 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/88 , C07D239/94 , C07D401/12 , C07D405/12 , C07D491/048 , C07D495/04 , C07D , A01N , A61K
CPC classification number: C07D239/34 , A01N43/54 , A01N43/90 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/88 , C07D239/94 , C07D401/12 , C07D405/12 , C07D495/04
-
公开(公告)号:AU623461B2
公开(公告)日:1992-05-14
申请号:AU4685689
申请日:1989-12-19
Applicant: HOECHST AG
Inventor: STARK HERBERT , SALBECK GERHARD , BONIN WERNER
IPC: A61K31/415 , A61P33/00 , C07D233/20 , C07D233/22 , C07D233/24
Abstract: The present invention relates to agents for systemic combating of ectoperasites in host animals, containing a compound of the formul I (I) in which R1 denotes hydrogen, (C1-C5)-alkyl, (C1-C3)-halogenoalkyl or halogen; R2 and R3 independently of one another denote (c1-C5)-alkyl, (C2-C5)-alkenyl, (C2-C5)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl, halogen, cyano, nitro, (C1-C5)-alkoxy, (C1 -C3)-alkoxy-C1-C3)-alkyl, (C1-C3)-halogenoalkoxy or (C1-C3)-alkylthio, or R2 and R3 together form a polymethylene chain having 2 to 5 carbon atoms: R4 denotes hydrogen, (c1-C10)-alkyl, (C2-C5)-alkenyl or (C3-C7)-cycloalkyl; R5 denotes hydrogen, (C1-C10)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)- cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C hd 1-C3)-alkyl; X denotes oxygen, sulfur or an -NR6-group; and R6 denotes hydrogen, (C1-C5)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)-cycloalkyl, C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C1 -C3)-alkyl, or biologically tolerated acid addition salts thereof. The compounds of the formulas I are novel in some cases and are likewise included in the invention.
-
公开(公告)号:AU622521B2
公开(公告)日:1992-04-09
申请号:AU4910590
申请日:1990-02-05
Applicant: HOECHST AG
Inventor: KRATT GUNTER , SALBECK GERHARD , BONIN WERNER , DUWEL DIETER
IPC: C07D239/557 , A01N43/54 , A01N57/36 , C07C217/84 , C07C265/12 , C07C323/36 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D239/62 , C07D319/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07F9/6584 , C07D239/64
-
公开(公告)号:ZA90830B
公开(公告)日:1991-02-27
申请号:ZA90830
申请日:1990-02-05
Applicant: HOECHST AG
Inventor: KRATT GUENTER , GUENTER KRATT , SALBECK GERHARD , GERHARD SALBECK , BONIN WERNER , WERNER BONIN , DUEWEL DIETER , DIETER DUEWEL
IPC: C07D239/557 , A01N43/54 , A01N57/36 , C07C217/84 , C07C265/12 , C07C323/36 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D239/62 , C07D319/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07F9/6584 , C07D , A01N , A61K , C07C
-
公开(公告)号:ZA899722B
公开(公告)日:1990-09-26
申请号:ZA899722
申请日:1989-12-19
Applicant: HOECHST AG
Inventor: STARK HERBERT , HERBERT STARK , SALBECK GERHARD , GERHARD SALBECK , BONIN WERNER , WERNER BONIN
IPC: A61K31/415 , A61P33/00 , C07D233/20 , C07D233/22 , C07D233/24 , C07D , A01N
Abstract: The present invention relates to agents for systemic combating of ectoperasites in host animals, containing a compound of the formul I (I) in which R1 denotes hydrogen, (C1-C5)-alkyl, (C1-C3)-halogenoalkyl or halogen; R2 and R3 independently of one another denote (c1-C5)-alkyl, (C2-C5)-alkenyl, (C2-C5)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl, halogen, cyano, nitro, (C1-C5)-alkoxy, (C1 -C3)-alkoxy-C1-C3)-alkyl, (C1-C3)-halogenoalkoxy or (C1-C3)-alkylthio, or R2 and R3 together form a polymethylene chain having 2 to 5 carbon atoms: R4 denotes hydrogen, (c1-C10)-alkyl, (C2-C5)-alkenyl or (C3-C7)-cycloalkyl; R5 denotes hydrogen, (C1-C10)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)- cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C hd 1-C3)-alkyl; X denotes oxygen, sulfur or an -NR6-group; and R6 denotes hydrogen, (C1-C5)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)-cycloalkyl, C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C1 -C3)-alkyl, or biologically tolerated acid addition salts thereof. The compounds of the formulas I are novel in some cases and are likewise included in the invention.
-
公开(公告)号:AU4910590A
公开(公告)日:1990-08-09
申请号:AU4910590
申请日:1990-02-05
Applicant: HOECHST AG
Inventor: KRATT GUNTER , SALBECK GERHARD , BONIN WERNER , DUWEL DIETER
IPC: C07D239/557 , A01N43/54 , A01N57/36 , C07C217/84 , C07C265/12 , C07C323/36 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D239/62 , C07D319/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07F9/6584 , C07D239/64
-
公开(公告)号:CA2009301A1
公开(公告)日:1990-08-06
申请号:CA2009301
申请日:1990-02-05
Applicant: HOECHST AG
Inventor: KRATT GUNTER , SALBECK GERHARD , BONIN WERNER , DUWEL DIETER
IPC: C07D239/557 , A01N43/54 , A01N57/36 , C07C217/84 , C07C265/12 , C07C323/36 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D239/62 , C07D319/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07F9/6584
Abstract: of the disclosure HOE 89/F 043 Pyrimidinetrione derivatives, processes for their preparation, agents containing them and their use as agents for combating pests Compounds of the formula I, tautomeric forms thereof of the formula Ia, stereoisomers thereof and the mixtures of these forms (I), (Ia), wherein R1 and R2 denote unsubstituted or substituted alkyl, alkenyl, alkynyl; alkoxy, alkylsulfonyl, alkylcarbonyl or cyano or optionally substituted phenyl, phenylsulfonyl or phenylcarbonyl, R3 denotes hydrogen, alkyl or optionally sub stituted phenyl, R4 denotes H, OH, unsubstituted or substituted alkyl, alkenyl, alkynyl, phenylsulfonyl, phenylcarbonyl, phenylcarbamoyl or phenyl; alkylsulfonyl or alkylcarbonyl, which can be halogenated, alkylcarbamoyl or cyano, R5 and R6 denote halogen, alkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, alkylsulfenyl, -sulfinyl or -sulfonyl, haloalkoxy, alkylamino, cyano, sulfo or nitro, A,X,Z and B denote oxygen, sulfur, sulfinyl, sulfonyl or nitrogen, which can be substituted by alkyl, or B denotes a double bond, C,D,E,F and G denote carbon or nitrogen, V denotes carbon or substituted phosphorus, W denotes alkylene or haloalkylene, both of which can be substituted, Y1 denotes H, halogen, alkyl, alkylamino or hydroxyl, Y2 denotes oxygen, sulfur or nitrogen which is optionally substituted by alkyl and n and m denote 0-4, and salts thereof which can be employed in agriculture or are physiologically tolerated, have advantageous actions against a broad spectrum of animal pests in agriculture and animal breeding.
-
公开(公告)号:DK648489A
公开(公告)日:1990-06-21
申请号:DK648489
申请日:1989-12-19
Applicant: HOECHST AG
Inventor: STARK HERBERT , SALBECK GERHARD , BONIN WERNER
IPC: A61K31/415 , A61P33/00 , C07D233/20 , C07D233/22 , C07D233/24 , A01N43/50
Abstract: The present invention relates to agents for systemic combating of ectoperasites in host animals, containing a compound of the formul I (I) in which R1 denotes hydrogen, (C1-C5)-alkyl, (C1-C3)-halogenoalkyl or halogen; R2 and R3 independently of one another denote (c1-C5)-alkyl, (C2-C5)-alkenyl, (C2-C5)-alkynyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl, halogen, cyano, nitro, (C1-C5)-alkoxy, (C1 -C3)-alkoxy-C1-C3)-alkyl, (C1-C3)-halogenoalkoxy or (C1-C3)-alkylthio, or R2 and R3 together form a polymethylene chain having 2 to 5 carbon atoms: R4 denotes hydrogen, (c1-C10)-alkyl, (C2-C5)-alkenyl or (C3-C7)-cycloalkyl; R5 denotes hydrogen, (C1-C10)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)- cycloalkyl, (C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C hd 1-C3)-alkyl; X denotes oxygen, sulfur or an -NR6-group; and R6 denotes hydrogen, (C1-C5)-alkyl, (C3-C5)-alkenyl, C3-C5)-alkynyl, (C3-C7)-cycloalkyl, C3-C7)-cycloalkenyl, (C1-C3)-halogenoalkyl or (C1-C3)-alkoxy-(C1 -C3)-alkyl, or biologically tolerated acid addition salts thereof. The compounds of the formulas I are novel in some cases and are likewise included in the invention.
-
公开(公告)号:ZA894181B
公开(公告)日:1990-02-28
申请号:ZA894181
申请日:1989-06-02
Applicant: HOECHST AG
Inventor: BONIN WERNER , HABERMANN PAUL , TRIPIER DOMINIQUE , WOEHNER ELISABET
IPC: A61K35/56 , A61K38/00 , A61K38/55 , A61P7/02 , C07K1/14 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/44 , C07K14/81 , C07K , A61K
Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.
-
-
-
-
-
-
-
-
-