公开(公告)号：PT85443A

公开(公告)日：1987-08-01

申请号：PT8544387

申请日：1987-07-29

Applicant: HOECHST AG

Inventor： KUETTNER KLAUS E ,  DIMUZIO MICHAEL T ,  BROCKS DIETRICH ,  TRIPIER DOMINIQUE

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/00 ,  C07K14/81 ,  C12N9/99 ,  C12P21/06 ,  C07K3/00 ,  C07K1/00 ,  C07K7/06 ,  C07K7/08

Abstract: A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.

公开(公告)号：NO862876A

公开(公告)日：1987-01-19

申请号：NO862876

申请日：1986-07-16

Applicant: HOECHST AG

Inventor： KRAMER MARTIN ,  TRIPIER DOMINIQUE

IPC: C07K1/06 ,  A61K35/62 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/12 ,  C07K1/14 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C07K

CPC classification number: C07K14/815 ,  A61K38/00 ,  Y10S930/26

公开(公告)号：DK338486A

公开(公告)日：1987-01-18

申请号：DK338486

申请日：1986-07-16

Applicant: HOECHST AG

Inventor： KRAMER MARTIN ,  TRIPIER DOMINIQUE

IPC: C07K1/06 ,  A61K35/62 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K1/00 ,  C07K1/12 ,  C07K1/14 ,  C07K1/20 ,  C07K1/22 ,  C07K14/00 ,  C07K14/435 ,  C07K14/81 ,  C07K14/815 ,  C07K

Abstract: The invention relates to a polypeptide of the formula (I) +TR in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

公开(公告)号：HUT37806A

公开(公告)日：1986-02-28

申请号：HU134185

申请日：1985-04-11

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07K7/52

Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

公开(公告)号：HUT37657A

公开(公告)日：1986-01-23

申请号：HU412184

申请日：1984-11-06

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  TRIPIER DOMINIQUE ,  RITZEL HARALD

IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55 ,  C07K7/00 ,  C07K7/64 ,  C07K14/00 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P7/64 ,  C12P13/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/485

Abstract: Cyclic polypeptides of the formula I I in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an alpha -amylase-inhibiting action.

公开(公告)号：NO851535L

公开(公告)日：1985-10-21

申请号：NO851535

申请日：1985-04-17

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07K

Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

公开(公告)号：FI851521L

公开(公告)日：1985-10-19

申请号：FI851521

申请日：1985-04-16

Applicant: HOECHST AG

Inventor： TRIPIER DOMINIQUE

IPC: C07K1/113 ,  A61K35/56 ,  A61K35/62 ,  A61K38/00 ,  A61K38/46 ,  A61K38/55 ,  A61P7/02 ,  C07C20060101 ,  C07G20060101 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C07K

Abstract: The invention relates to polypeptides of the formula I (I) in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring alpha -amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring alpha -amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

公开(公告)号：ZA848651B

公开(公告)日：1985-06-26

申请号：ZA848651

申请日：1984-11-06

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  TRIPIER DOMINIQUE ,  RITZEL HARALD

IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61K38/55 ,  C07K7/00 ,  C07K7/64 ,  C07K14/00 ,  C07K14/195 ,  C07K14/36 ,  C07K14/41 ,  C12N9/99 ,  C12P7/64 ,  C12P13/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/485 ,  A61K ,  C12N ,  C12P ,  C07G ,  C12R ,  C12Q ,  G01N ,  C07D

Abstract: Cyclic polypeptides of the formula I I in which Z, S, Y and AS have the meanings given, a process for their preparation and their use are described. The compounds have an alpha -amylase-inhibiting action.

公开(公告)号：ZA8305951B

公开(公告)日：1984-04-25

申请号：ZA8305951

申请日：1983-08-12

Applicant: HOECHST AG

Inventor： SEIPKE GERHARD ,  TRIPIER DOMINIQUE ,  JOHNSCHER GERD

IPC: A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K1/113 ,  C07K1/20 ,  C07K14/435 ,  C07K14/47 ,  C07K14/575 ,  G01N

CPC classification number: C07K14/575 ,  A61K38/00 ,  C07K14/47 ,  Y10S530/837 ,  Y10S530/838 ,  Y10S530/854

公开(公告)号：SK281333B6

公开(公告)日：2001-02-12

申请号：SK255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.