公开(公告)号：AU1621797A

公开(公告)日：1997-09-18

申请号：AU1621797

申请日：1997-03-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WAGNER ADALBERT ,  WIRTH KLAUS ,  SCHOLKENS BERNWARD ,  NOLKEN GERHARD

IPC: C07D215/48 ,  A61K31/47 ,  A61P43/00 ,  C07D215/26

Abstract: 8-(3-(Aminoalkoxy)-benzyloxy)-quinoline compounds of formula (I) and their salts are new. R1-R3 = H, halo, CHO, COOH, 1-5C alkyl, 6-10C aryl, 1-3C alkyl-(6-10C) aryl, 3-8C cycloalkyl or 1-3C alkoxycarbonyl; R4, R5 = H, halo, NO2, CN, 1-3C alkoxy or 1-3C alkylthio; R6 = H, 1-3C alkyl, 3-5C alkylalkenyl (sic) or 1-3C alkyl-6-10C aryl; R7 = H, 1-6C alkanoyl, alkanoyl (substituted by 1-3C alkoxy, alkylcarbamoyl or aryl), 3-7C alkenoyl, 3-8C cycloalkylcarbonyl, 5-7C cycloalkenylcarbonyl, 1-3C alkoxycarbonyl, aryloxycarbonyl, 6-12C aroyl (optionally substituted by 1-3C alkoxy or halo), alkenoyl (substituted by aryl (optionally substituted by 1-3C alkoxy, 1-3C alkylenedioxy, NO2, CN, halo, 1-3C haloalkyl, hetero-3-8C cycloalkyl (sic), NH2, 1-4C alkylamino, 6-12C heteroaryl-alkanoylamino, aroylamino, 6-12C heteroarylcarbonylamino, 1-5C alkylsulphonylamino, 1-5C alkylureido, alkanoyl, 1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl or arylcarbamoyl), 2-5C acylamino-arylcinnamoyl, 1-3C alkoxycarbonylamino-arylcinnamoyl, 1-4C alkylaminocarbonylaminocinnamoyl, aryl-1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl, arylcarbamoyl, aroylcarbamoyl, alkylsulphonyl, arylsulphonyl, aryl-alkylsulphonyl or phthaloyl (for R6=R7(sic)); n = 1-8; alkyl has 1-6C, aryl has 6-12C, alkanoyl has 2-6C, and alkenoyl has 3-6C unless specified other wise.

公开(公告)号：PL318923A1

公开(公告)日：1997-09-15

申请号：PL31892397

申请日：1997-03-12

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  WAGNER ADALBERT ,  WIRTH KLAUS ,  SCHOELKENS BERNWARD ,  NOELKEN GERHARD

IPC: A61K31/47 ,  A61P43/00 ,  C07D215/48 ,  C07D215/26 ,  C07D215/24

Abstract: 8-(3-(Aminoalkoxy)-benzyloxy)-quinoline compounds of formula (I) and their salts are new. R1-R3 = H, halo, CHO, COOH, 1-5C alkyl, 6-10C aryl, 1-3C alkyl-(6-10C) aryl, 3-8C cycloalkyl or 1-3C alkoxycarbonyl; R4, R5 = H, halo, NO2, CN, 1-3C alkoxy or 1-3C alkylthio; R6 = H, 1-3C alkyl, 3-5C alkylalkenyl (sic) or 1-3C alkyl-6-10C aryl; R7 = H, 1-6C alkanoyl, alkanoyl (substituted by 1-3C alkoxy, alkylcarbamoyl or aryl), 3-7C alkenoyl, 3-8C cycloalkylcarbonyl, 5-7C cycloalkenylcarbonyl, 1-3C alkoxycarbonyl, aryloxycarbonyl, 6-12C aroyl (optionally substituted by 1-3C alkoxy or halo), alkenoyl (substituted by aryl (optionally substituted by 1-3C alkoxy, 1-3C alkylenedioxy, NO2, CN, halo, 1-3C haloalkyl, hetero-3-8C cycloalkyl (sic), NH2, 1-4C alkylamino, 6-12C heteroaryl-alkanoylamino, aroylamino, 6-12C heteroarylcarbonylamino, 1-5C alkylsulphonylamino, 1-5C alkylureido, alkanoyl, 1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl or arylcarbamoyl), 2-5C acylamino-arylcinnamoyl, 1-3C alkoxycarbonylamino-arylcinnamoyl, 1-4C alkylaminocarbonylaminocinnamoyl, aryl-1-5C alkoxycarbonyl, 1-5C alkylcarbamoyl, arylcarbamoyl, aroylcarbamoyl, alkylsulphonyl, arylsulphonyl, aryl-alkylsulphonyl or phthaloyl (for R6=R7(sic)); n = 1-8; alkyl has 1-6C, aryl has 6-12C, alkanoyl has 2-6C, and alkenoyl has 3-6C unless specified other wise.

公开(公告)号：NO179283C

公开(公告)日：1996-09-11

申请号：NO912848

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：HU212420B

公开(公告)日：1996-06-28

申请号：HU243291

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： GERHARDS HERMANN ,  HENNING RAINER ,  SCHOELKENS BERNWARD ,  WAGNER ADALBERT

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：NO179283B

公开(公告)日：1996-06-03

申请号：NO912848

申请日：1991-07-19

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  WAGNER ADALBERT ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61P1/16 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P43/00 ,  C07D233/56 ,  C07D233/90 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substd. azole derivs. of formula (I) and their physiologically acceptable salts are new. In (I) X, Y and Z are each N or CR2 R1 is 2-10C alkyl, 3-10C alkenyl, 3-10C alkynyl, -(CH2)mB(CH2nR4 (these 4 gps. opt. monosubstd. with CO2R3 and opt. have 1-all H atoms replaced by F), OR3, 3-8C cycloalkyl, 5-10C cycloalkylalkynyl, or benzyl (opt. mono or disubstd. on the Ph ring with halogen, 1-4C alkoxy and/or NO2), R2 = H, halogen, CvF2v+1, SF5, pentafluoro phenyl CN, phenyl, -(CH2)nF, -(CH2)nONO2, -CH2N3, -(CH2)nNO2, phthalimido (CH2)n-, R3 = H, 1-8C alkyl (in which 1 to all H are replaced by F), 3-8C cycloalkyl, Ph or benzyl, R4 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-4C alkenyl, or 2-4C alkynyl, A = a mono or bicyclic unsatd. or partially hydrogenated heterocycle gp. with 5-10 ring atom of which up to 9 are C, and opt. substd. with up to 3 opt. different R14 gps. or -(CH2)n-1-(CHR6CH2)0-1, R14 where R14 = halogen, oxo, nitroso, NO2, amino, CN, OH, 1-6C alkyl, 1-4C alkanoyl, 1-4C alkanoyloxy. B = O, NR7 or S, W = O or S, L = 1-3C alkanediyl, R26 and R27 are each H, halogen, NO2, 1-4C alkyl or 1-2C alkoxy, n = 1-5, o = 1-10, q = 0-1.

公开(公告)号：LTIP716A

公开(公告)日：1995-01-31

申请号：LTIP716

申请日：1993-06-25

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K20060101 ,  A61K31/40 ,  A61K31/425 ,  C07D20060101 ,  C07D207/30 ,  C07D257/04 ,  C09F20060101

公开(公告)号：NZ237644A

公开(公告)日：1994-12-22

申请号：NZ23764491

申请日：1991-03-28

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  HENNING RAINER ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/415 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04 ,  A61K31/42

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：NO176104B

公开(公告)日：1994-10-24

申请号：NO873183

申请日：1987-07-29

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: A61K31/415 ,  A61K38/00 ,  C07D233/54 ,  C07D233/64 ,  C07K1/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08

Abstract: The invention relates to compounds of the formula in which R1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R2, R3 and R4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.

公开(公告)号：NO933904L

公开(公告)日：1994-05-02

申请号：NO933904

申请日：1993-10-28

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  REGNAT DIETER ,  KLEINER HANS-JERG

IPC: C07B39/00 ,  C07C17/14 ,  C07C22/04 ,  C07C67/307 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C205/12 ,  C07C255/50 ,  C07C257/12 ,  C07C257/20 ,  C07C311/05 ,  C07C311/18 ,  C07C311/53 ,  C07D275/04 ,  C07D275/06 ,  C07D333/24 ,  C07D333/60 ,  C07D333/68 ,  C07D333/70 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D333/12

Abstract: Aromatic bromomethyl compounds play an important role in the synthesis of active substances. They can be obtained in particularly high purity by free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.

公开(公告)号：FI934749A

公开(公告)日：1994-04-30

申请号：FI934749

申请日：1993-10-27

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER ,  REGNAT DIETER ,  KLEINER HANS-JERG

IPC: C07B39/00 ,  C07C17/14 ,  C07C22/04 ,  C07C67/307 ,  C07C67/343 ,  C07C69/65 ,  C07C69/76 ,  C07C205/12 ,  C07C255/50 ,  C07C257/12 ,  C07C257/20 ,  C07C311/05 ,  C07C311/18 ,  C07C311/53 ,  C07D275/04 ,  C07D275/06 ,  C07D333/24 ,  C07D333/60 ,  C07D333/68 ,  C07D333/70 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D333/12

Abstract: Aromatic bromomethyl compounds play an important role in the synthesis of active substances. They can be obtained in particularly high purity by free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.