公开(公告)号：NO941680A

公开(公告)日：1994-11-09

申请号：NO941680

申请日：1994-05-06

Applicant: HOECHST AG

Inventor： GLOMBIK HEINER ,  ENHSEN ALFONS ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61K31/58 ,  A61P3/06 ,  A61P9/10 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00

CPC classification number: C07J51/00 ,  C07J9/005 ,  C07J31/006 ,  C07J41/0055 ,  C07J41/0088 ,  C07J43/003

公开(公告)号：AU652928B2

公开(公告)日：1994-09-15

申请号：AU6921791

申请日：1991-01-08

Applicant: HOECHST AG

Inventor： WEITHMANN KLAUS-ULRICH ,  WESS GUNTHER ,  SEIFFGE DIRK

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/00 ,  C07D311/58 ,  C07D311/66 ,  C07D319/06 ,  C07D339/00 ,  C07D339/04 ,  C07D339/08 ,  C07F9/655 ,  C07F9/6558 ,  C07J9/00 ,  C07J11/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C09K15/04 ,  C07C235/50 ,  C07C49/835 ,  C07C69/738 ,  C07C43/178 ,  C09K15/08 ,  C09K15/24 ,  C07F9/40 ,  C07C323/52 ,  C07C69/88 ,  C07C69/732 ,  C07C39/11 ,  C07C59/52 ,  C07C61/22 ,  C07C69/157 ,  C07C323/12 ,  C07C323/60 ,  A61K31/575 ,  A61K31/165 ,  A61K31/05 ,  A61K31/385 ,  C07F9/11 ,  A23L3/3436 ,  C09K15/14 ,  C07D307/62

Abstract: Lipid-selective antioxidants of the general formula I (A)a(L)(X)a(I> in which A = antioxidant component, L = linker, X = lipophilic component, a and a' = independently of one another the numbers 1 or 2. The compounds are used to protect lipid-containing substances from oxidation and in pharmaceutical compositions for the prophylaxis and therapy of diseases in which bioradicals are involved, in particular diseases of the heart, circulation and vessels.

公开(公告)号：NO175002B

公开(公告)日：1994-05-09

申请号：NO903911

申请日：1990-09-07

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  WESS GUNTHER ,  KESSELER KURT ,  BECK GERHARD

IPC: A61K31/35 ,  C07D319/06 ,  A61K31/357 ,  A61K31/365 ,  A61K31/366 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C1/24 ,  C07C17/12 ,  C07C17/26 ,  C07C39/08 ,  C07C43/23 ,  C07C45/46 ,  C07C46/04 ,  C07C50/24 ,  C07C69/712 ,  C07C323/20 ,  C07C331/10 ,  C07D309/30

Abstract: Compounds of the formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y, R , R , R , R , R have the stated meanings, and their pharmacologically acceptable salts with bases and their pharmacologically acceptable esters, process for the preparation of these compounds, their use as drugs, and pharmaceutical preparations are described. Also described are compounds of the formula III in which R , R , R , R , R , X and Y have the stated meanings.

公开(公告)号：SK58593A3

公开(公告)日：1994-03-09

申请号：SK58593

申请日：1993-06-10

Applicant: HOECHST AG

Inventor： ENHSEN ALFONS ,  GLOMBIK HEINER ,  KRAMER WERNER ,  WESS GUNTHER

IPC: A61K31/575 ,  A61P1/00 ,  A61P3/00 ,  A61P3/06 ,  A61P7/00 ,  C07H9/00 ,  C07J9/00 ,  C07J41/00 ,  C07J75/00

Abstract: Bile acid derivatives of the formula I Z(X-GS)n in which GS, X, Z and n have the stated meanings, and a process for the production of these compounds are described. The compounds have pharmacological activity and can therefore be used as pharmaceuticals, in particular as hypolipidaemic.

公开(公告)号：NZ236709A

公开(公告)日：1992-11-25

申请号：NZ23670991

申请日：1991-01-07

Applicant: HOECHST AG

Inventor： WEITHMANN KLAUS-ULRICH ,  WESS GUNTHER ,  SEIFFGE DIRK

IPC: A61K31/352 ,  A61P9/00 ,  C07D311/58 ,  C07D311/66 ,  C07D319/06 ,  C07D339/00 ,  C07D339/04 ,  C07D339/08 ,  C07F9/655 ,  C07F9/6558 ,  C07J9/00 ,  C07J11/00 ,  C07J17/00 ,  C07J31/00 ,  C07J33/00 ,  C07J41/00 ,  C09K15/04 ,  A61K31/35 ,  C07C39/11 ,  C07C43/13 ,  C07C49/217 ,  C07C59/11 ,  C07C62/34 ,  C07C69/612 ,  C07C69/618 ,  C07C69/88 ,  C07C235/50 ,  C07C323/41 ,  C07C323/52 ,  C07C323/56 ,  C07D307/33 ,  C07D311/04 ,  C07D407/12 ,  C07F9/113 ,  C07F9/40 ,  A23L3/34 ,  C08L91/00 ,  C11B5/00 ,  A61K31/05 ,  A61K31/08 ,  A61K31/12

Abstract: Lipid-selective antioxidants of the general formula I (A)a(L)(X)a(I> in which A = antioxidant component, L = linker, X = lipophilic component, a and a' = independently of one another the numbers 1 or 2. The compounds are used to protect lipid-containing substances from oxidation and in pharmaceutical compositions for the prophylaxis and therapy of diseases in which bioradicals are involved, in particular diseases of the heart, circulation and vessels.

公开(公告)号：PH26257A

公开(公告)日：1992-04-01

申请号：PH38636

申请日：1989-05-11

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  BECK GERHARD ,  WESS GUNTHER ,  BARTMANN WILHEIM

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30 ,  C07C59/13 ,  C07C149/40 ,  C07C149/34 ,  C07C43/225

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：ZA907300B

公开(公告)日：1991-06-26

申请号：ZA907300

申请日：1990-09-13

Applicant: HOECHST AG

Inventor： KRAMER WERNER ,  WERNER KRAMER ,  WESS GUNTHER ,  GUNTHER WESS

IPC: A61K38/00 ,  A61K31/575 ,  A61K31/58 ,  A61P1/16 ,  A61P3/06 ,  A61P43/00 ,  C07D213/26 ,  C07D213/56 ,  C07D213/81 ,  C07J9/00 ,  C07J17/00 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J51/00 ,  C07K5/06 ,  C07K5/062 ,  C07J ,  A61K

Abstract: Bile acid derivatives of the formula I W-X-G in which G is a bile acid residue, W is an active substance portion of a medicament and X is a linker between bile acid residue and active substance portion, are outstandingly suitable for introducing active substances into the enterohepatic circulation. The compounds I are absorbed and enter the bloodstream. This makes it possible by utilising the natural reabsorption of the bile acids to improve the absorption of drugs which are absorbed with difficulty, if at all. W can be, for example, a peptide, an antibiotic, an antiviral substance, an anticancer agent, a liver protective, an antihyperlipidaemic, a diuretic, an agent to lower blood pressure, a renin inhibitor, a substance to treat cirrhosis of the liver or a substance for treating diabetes. G is a bile acid residue in the form of the free, natural or chemically modified acids, the esters and amides, the salt forms and forms derivatised on alcohol groups. X is a large number of intermediate members or else a bond.

公开(公告)号：NZ229083A

公开(公告)日：1990-12-21

申请号：NZ22908389

申请日：1989-05-11

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  WESS GUNTHER ,  BARTMANN WILHELM ,  BECK GERHARD

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30 ,  C07C149/34

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.

公开(公告)号：NZ225517A

公开(公告)日：1990-11-27

申请号：NZ22551788

申请日：1988-07-22

Applicant: HOECHST AG

Inventor： WESS GUNTHER ,  BARTMANN WILHELM ,  BECK GERHARD ,  ANAGNOSTOPULOS HIRISTO

IPC: A61K31/085 ,  A61K31/10 ,  A61K31/12 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/34 ,  A61K31/381 ,  A61K31/395 ,  A61K31/41 ,  A61K31/44 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/04 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C43/00 ,  C07C43/178 ,  C07C43/20 ,  C07C43/235 ,  C07C43/263 ,  C07C45/00 ,  C07C47/52 ,  C07C49/84 ,  C07C51/00 ,  A61K31/38 ,  C07C59/125 ,  C07C65/21 ,  C07C67/00 ,  C07C69/007 ,  C07C69/025 ,  C07C69/675 ,  C07C69/92 ,  C07C201/00 ,  C07C235/06 ,  C07C235/16 ,  C07C239/00 ,  C07C239/14 ,  C07C313/00 ,  C07C317/00 ,  C07C317/04 ,  C07C317/18 ,  C07C317/22 ,  C07C317/24 ,  C07C317/44 ,  C07C317/46 ,  C07C323/00 ,  C07C323/16 ,  C07C323/19 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C323/60 ,  C07C323/65 ,  C07D213/30 ,  C07D257/04 ,  C07D295/18 ,  C07D317/36 ,  C07D317/38 ,  C07D333/16 ,  C07C147/06 ,  C07C147/11 ,  C07C147/14 ,  C07C103/22 ,  C07C103/26 ,  C07C69/612 ,  C07D207/08 ,  C07D211/30 ,  C07D213/24 ,  C07D213/63 ,  C07C149/267 ,  C07C149/273 ,  C07C83/10 ,  C07C43/205 ,  C07C49/213 ,  C07C57/30 ,  C07D265/30 ,  C07D295/04 ,  C07D317/14 ,  C07D317/34 ,  A61K31/335

Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.

公开(公告)号：PT90532A

公开(公告)日：1989-11-30

申请号：PT9053289

申请日：1989-05-11

Applicant: HOECHST AG

Inventor： JENDRALLA HEINER ,  BARTMANN WILHELM ,  WESS GUNTHER ,  BEACK GERHARD

IPC: A61K31/365 ,  A61K31/185 ,  A61K31/19 ,  A61K31/35 ,  A61K31/366 ,  A61P3/06 ,  C07C39/367 ,  C07C59/64 ,  C07C59/68 ,  C07C323/01 ,  C07C323/09 ,  C07D309/30 ,  C07D309/00 ,  C07C59/00 ,  C07F13/00 ,  A61K31/235

Abstract: Compounds of the general formula I and the corresponding open-chain dihydroxy carboxylic acids of the formula II in which X, Y and Z have the stated meanings, and their pharmacologically tolerated salts with bases and their pharmacologically tolerated esters, process for preparing this compound, its use as pharmaceutical and pharmaceutical products are described. Also described are phenols and thiophenols of the formula III in which X, Y and Z have the stated meanings.