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166 records (took 0.026 seconds)

    83.
    发明专利
    未知

    公开(公告)号：BRPI0614217A2

    公开(公告)日：2011-03-22

    申请号：BRPI0614217

    申请日：2006-07-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

    ESTABILIZACION DE DESHIDROGENASAS CON COENZIMAS ESTABLES
    86.
    发明专利
    ESTABILIZACION DE DESHIDROGENASAS CON COENZIMAS ESTABLES 未知

    公开(公告)号：AR070436A1

    公开(公告)日：2010-04-07

    申请号：ARP090100571

    申请日：2009-02-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： HEINDL DIETER ,  HORN CARINA ,  HOENES JOACHIM ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C12N9/96 ,  C12N9/06 ,  C12Q1/32

    Abstract: Procedimiento para la estabilizacion de una enzima deshidrogenasa por almacenamiento de la enzima en presencia de una coenzima estable. Además una enzima estabilizada con una coenzima estable así como también a su uso en elementos de prueba para la determinacion de substancias a analizar. Reivindicacion 5: Procedimiento de acuerdo con una de las reivindicaciones 1 a 4, caracterizado porque la coenzima estable es seleccionada entre compuestos de nicotinamida-adenina-dinucleotido (NAD/NADH) y nicotinamida-adenina-dinucleotido fosfato (NADP/NADPH) estables y el compuesto de la Formula (1). Reivindicacion 6: Procedimiento de acuerdo con la reivindicacion 5, caracterizado porque la coenzima estable es seleccionada entre los compuestos con la formula general (2), con: A = adenina o un análogo de la misma, T = en cada caso independientemente O, S; U = en cada caso independientemente OH, SH, BH3-, BCNH2-; V = en cada caso independientemente OH o un grupo fosfato, o dos grupos que forman un grupo fosfato cíclico; W = COOR, CON(R)2, COR, CSN(R)2 con R = en cada caso independientemente H o alquilo C1-2; X1, X2 = en cada caso independientemente O, CH2, CHCH3, C(CH3)2, NH, NCH3; Y = NH, S, O, CH2; Z = es un resto orgánico lineal o cíclico, con la condicion de que Z y el resto piridina no estén unidos por una union glicosídica, o una sal o eventualmente una forma reducida del mismo.

    88.
    发明专利
    未知

    公开(公告)号：DK1504113T3

    公开(公告)日：2007-03-05

    申请号：DK03730061

    申请日：2003-05-16

    Applicant: HOFFMANN LA ROCHE

    Inventor： KNAPPE WOLFGANG-REINHOLD ,  HORN CARINA ,  HOENES JOACHIM

    IPC: C12M1/34 ,  C12Q1/00 ,  C08F2/00 ,  C12M1/40 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.

    Stable NAD/NADH derivatives
    89.
    发明专利
    Stable NAD/NADH derivatives 未知

    公开(公告)号：AU2006274140A1

    公开(公告)日：2007-02-01

    申请号：AU2006274140

    申请日：2006-07-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA ,  HOENES JOACHIM

    IPC: C07H19/207 ,  C07H19/213 ,  C07H21/00 ,  C07H21/02 ,  C07H23/00 ,  C12Q1/32

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

    90.
    发明专利
    未知

    公开(公告)号：AT345396T

    公开(公告)日：2006-12-15

    申请号：AT03730061

    申请日：2003-05-16

    Applicant: HOFFMANN LA ROCHE

    Inventor： HORN CARINA ,  HOENES JOACHIM ,  KNAPPE WOLFGANG-REINHOLD

    IPC: C12M1/34 ,  C08F2/00 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.

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