中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

535 records (took 0.024 seconds)

    82.
    发明专利
    未知

    公开(公告)号：AT254102T

    公开(公告)日：2003-11-15

    申请号：AT01400940

    申请日：2001-04-12

    Applicant: SERVIER LAB

    Inventor： PEGLION JEAN-LOUIS ,  DESSINGES AIMEE ,  GOUMENT BERTRAND ,  MILLAN MARK ,  LEJEUNE FRANCOISE ,  BROCCO MAURICETTE

    IPC: A61K31/138 ,  A61K31/343 ,  A61K31/357 ,  A61K31/381 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61P3/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  A61P43/00 ,  C07B61/00 ,  C07C213/08 ,  C07C215/42 ,  C07D209/16 ,  C07D209/30 ,  C07D209/40 ,  C07D209/70 ,  C07D307/93 ,  C07D317/70 ,  C07D319/14 ,  C07D333/78 ,  C07D407/12

    Abstract: Heterocycloalkyl and heteroaryl benzocyclobutane derivatives (I) are new. Heterocycloalkyl and heteroaryl benzocyclobutane derivatives (I), their isomers and salts, acids and bases are new. dotted line = single or double bond; n = 1-6; R1, R2 = H, 1-6C alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl alkyl, 2-6C alkenyl or alkynyl, heterocycloalkyl, heterocycloalkyl alkyl, heteroaryl, or heteroaryl alkyl; X = -CH=CH-, -O-, -S(O)m-, or -N(R3)-; n = 0-2; R3 = H, 1-6C alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl alkyl, or 2-6C alkenyl or alkynyl; Y = CH or CH2 depending on whether it is linked by a single or double bond, or it may be O when X is O; T = 3-12C mono- or polycyclic cycloalkyl in which one of the C atoms may be replaced by O, Se, SOp, R3 or SiR4R5; p = 0-2; R4, R5 = 1-6C alkyl. Within the definition of (I), aryl groups may be phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl, indenyl, or benzocyclobutyl, each of which may be substituted by one or more of the following: halogen, 1-6C alkyl or alkoxy, OH, NO2, CN, 1-6C trihaloalkyl, NH2, or mono- or di-alkylamino, heteroaryl groups comprise an aryl group as defined above containing 1-3 hetero atoms (O, N, S) in the cyclic system and optionally substituted as before, cycloalkyl groups may be mono- or polycyclic of 3-12 members, optionally containing unsaturations and optionally substituted as before, and heterocycloalkyl groups comprise a cycloalkyl groups as defined that may have one or more unsaturations and containing 1-3 heteroatoms (O, N, S) in the ring. An Independent claim is also included for preparations of (I).

    87.
    发明专利
    未知

    公开(公告)号：NO315513B1

    公开(公告)日：2003-09-15

    申请号：NO20001542

    申请日：2000-03-24

    Applicant: SERVIER LAB

    Inventor： PEGLION JEAN-LOUIS ,  GOUMENT BERTRAND ,  DESSINGES AIMEE ,  MILLAN MARK ,  DEKEYNE ANNE ,  RIVET JEAN-MICHEL

    IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4245 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  A61P43/00 ,  C07D209/00 ,  C07D209/70 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D209/56

    Abstract: cis-Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives (I) are new. cis-Benzo(3,4)cyclobuta(1,2-c)pyrrole derivatives of formula (I) and their isomers and salts are new. R1 - R3 = H, halogen, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, OH, 1-6C alkoxy, cycloalkyl, cycloalkyl(1-6C)alkyl, aryl, aryl(1-6C)alkyl, aryloxy, aryl(1-6C)alkoxy, 1-6C trihaloalkyl, 1-6C trihaloalkoxy,CN, NO2, OSO2Me, OSO2CF3, NR6R7 or COOR6; or two adjacent R1 - R3 groups = 4-8C optionally saturated ring in which 1-2 C atoms can be replaced by O, N and/or S; R6, R7 = H, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, cycloalkyl, cycloalkyl(1-6C)alkyl, aryl or aryl(1-6C)alkyl; R4 = H, 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, cycloalkyl, cycloalkyl(1-6C)alkyl, aryl, aryl(1-6C)alkyl, heterocycloalkyl, heterocycloalkyl(1-6C)alkyl, heteroaryl or heteroaryl(1-6C)alkyl; R5 = aryl or heteroaryl optionally substituted by halogen, OH, 1-6C alkyl, 1-6C alkoxy, 2-6C alkenyl, cycloalkyl, adamantyl, cycloalkyl(1-6C)alkyl, aryl, aryl(1-6C)alkyl, aryloxy, aryl(1-6C)alkoxy, 1-6C trihaloalkyl, CN, NO2, oxo, OSO2Me, OSO2CF3, NR6R7 or COOR6; n = 1 - 3; cycloalkyl = a 3-8C mono- or bicyclic optionally saturated ring system optionally substituted by halogen and/or 1-6C alkyl; heterocycloalkyl = cycloalkyl as defined in which the ring system contains 1-3 heteroatoms selected from O, N and S; aryl = phenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indenyl or indanyl; heteroaryl = aryl as defined containing 1-3 heteroatoms selected from O, N and S. An Independent claim is also included for a process for preparing (I).

    90.
    发明专利
    未知

    公开(公告)号：NO314402B1

    公开(公告)日：2003-03-17

    申请号：NO996285

    申请日：1999-12-17

    Applicant: SERVIER LAB

    Inventor： CORDI ALEX ,  MILLAN MARK ,  NEWMAN-TANCREDI ADRIAN ,  BROCCO MAURICETTE

    IPC: A61K31/4184 ,  A61P3/04 ,  A61P15/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D235/02

    Abstract: Spiro(imidazoline-anthracene) derivatives (I) are new. Spiro(imidazoline-anthracene) derivatives of formula (I) and their base or acid addition salts are new. R1-R4 = H, 1-6C alkyl, 1-6C alkoxy, OH, 1-6C polyhalogenoalkyl, cyano, nitro, amino, 1-6C alkylamino, di (1-6C) alkylamino, 1-6C thioalkyl, 1-6C sulfonylalkyl, 1-6C sulfinylalkyl, carboxy, 1-6C alkoxycarbonyl, 1-6C alkylcarbonyloxy, formyl, carbamoyl, carboxamide, phenyl, benzyl or halo; B' = a group of formula (i) or (ii); R = H, 1-6C alkyl or benzyl. Independent claims are also included for: (1) the preparation of (I); and (2) pharmaceutical compositions comprising at least one compound (I).

Patent Agency Ranking