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    2.
    发明专利
    未知

    公开(公告)号：TR200402685T4

    公开(公告)日：2004-11-22

    申请号：TR200402685

    申请日：2001-04-12

    Applicant: SERVIER LAB

    Inventor： PEGLION JEAN-LOUIS ,  GOUMENT BERTRAND ,  MILLAN MARK ,  LEJEUNE FRANCOISE ,  CUSSAC DIDIER

    IPC: A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  C07D401/12 ,  C07D401/14

    Abstract: Cyclobuta-indole derivatives (I), their isomers and salts are new. The new compounds are of formula (I): n = 0 - 6; R1 = H, OH, CN, alkoxy, alkoxycarbonyl, carboxy, amino carbonyl (optionally substituted by one or two alkyl, aryl, or aralkyl groups), or NR4R5; R2 = H, alkyl, CH2OH, a croup -(OH)(T), or -U'-V'-W'; T = 3-12C mono- or polycyclic cycloalkyl that may have one C atom replaced by O, Se, S, SO, SO2, or SiR6R7; R3 = H, alkyl, aryl, or heteroaryl; R4 and R5 = alkyl, aryl, aralkyl, heteroaryl, heteroaryl alkyl, cycloalkyl, cycloalkyl alkyl, alkenyl or alkynyl; R6 and R7 = alkyl; U' = methylene or a bond; V' = a bond, O, S, SO, or SO2; and W' = aryl aralkyl, cycloalkyl, or cycloalkyl alkyl. All alkyl, alkoxy, alkenyl and alkynyl groups having up to 6 C atoms, aryl, heteroaryl and cycloalkyl groups may be mono or polycyclic, aryl and heteroaryl groups may be mono or polysubstituted and cycloalkyl groups may contain unsaturation.

    CHROMENE DERIVATIVES, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    4.
    发明专利
    CHROMENE DERIVATIVES, PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知

    公开(公告)号：HU222728B1

    公开(公告)日：2003-09-29

    申请号：HU9801423

    申请日：1998-06-23

    Applicant: SERVIER LAB

    Inventor： DUBUFFET THIERRY ,  HAUTEFAYE PATRICK ,  LAVIELLE GILBERT ,  LEJEUNE FRANCOISE ,  MILLAN MARK

    IPC: A61K31/40 ,  A61K31/435 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07B53/00 ,  C07D491/04 ,  C07D491/052

    Abstract: Hexahydro-chromeno-Ä3,4-cÜ-pyrrole derivatives of formula (I), their enantiomers, diastereoisomers and salts are new. m = 0-3; n = 0-3; n+m = 2 or 3; p = 1-6; the junction between rings B and C is trans; X = CN or -CONR4R5; R4, R5 = H, 1-6C alkyl, 3-7C cycloalkyl or optionally substituted aryl; A = sigma bond or -NR-CO-, -CO-NR-, -NR-SO2-, or -SO2-NR-; R = H or 1-6C alkyl; R1, R2 = H or 1-6C alkyl; R3 = H or phenyl, naphthyl or heteroaryl (all optionally substituted by one or more halo, 1-6C alkyl or alkoxy, OH, CN, NH2, NO2, COOH, 1-6C perhaloalkyl, sulphonyl, acylamino, 1-6C alkylsulphonyl, or 1-6C alkyl sulphonylamino), aryl or heteroaryl (both substituted by A'-Cy), 2-indolinon-5-yl, or, when A is a sigma bond, aryloxy or arylthio; A' = sigma bond or 1-6C alkylene or alkenylene, (in which one C atom may be replaced by O or S), -NR-CO-, -CO-NR-, -NR-SO2-, or -SO2-NR-; Cy = aryl or heteroaryl (optionally substituted); provided that when n = 0, then m is other than 2, when n = 1, R1, R2 = H, A = sigma bond and p = 1, then R3 is not phenyl nor pyridyl, when n = 1, R1 & R2 = H, A = sigma bond, R3 is not H, when n = 1, R1 & R2 = H, A = -NH-CO-, then R3 is other than H, phenyl, naphthyl, thienyl, furyl, pyrrolyl, pyridyl, (all optionally substituted by one or more halo, trihalomethyl, alkoxy or OH).

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