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    DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    1.
    发明申请
    DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
    1,2,4,5-四氢-3H-苯并嗪的衍生物，其制备方法及含有该化合物的药物组合物

    公开(公告)号：WO2009066041A2

    公开(公告)日：2009-05-28

    申请号：PCT/FR2008001268

    申请日：2008-09-11

    Applicant: SERVIER LAB ,  PEGLION JEAN-LOUIS ,  GOUMENT BERTRAND ,  DESSINGES AIMEE ,  CAIGNARD PASCAL ,  VILAINE JEAN-PAUL ,  THOLLON CATHERINE ,  VILLENEUVE NICOLE ,  CHIMENTI STEFANO

    Inventor： PEGLION JEAN-LOUIS ,  GOUMENT BERTRAND ,  DESSINGES AIMEE ,  CAIGNARD PASCAL ,  VILAINE JEAN-PAUL ,  THOLLON CATHERINE ,  VILLENEUVE NICOLE ,  CHIMENTI STEFANO

    CPC classification number: C07D223/16

    Abstract: The invention relates to compounds having formula (I), wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and alkyl, optionally substituted; R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, -OSO2R10, -OCOR10, alkoxy group, optionally substituted, or R2 and R3,or R3 and R4, or R4 and R5 together form a group -O-(CH2)q-O-, -O-CH=CH-O- or -O-CH=CH-; R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group -O-(CH2)q-O-; R10 a group selected from linear or branched alkoxy C1-C6, NR11R'11,and alkyl, optionally substituted; R11 and R'11 each represent a hydrogen atom or an alkyl group, or R11 and R'11 together with the nitrogen atom bearing same form an optionally substituted mono- or bi-cyclic nitrogenous heterocycle; - X represents O, NH or CH2; m and p each represent 0 or 1; n and q each represent 1 or 2, said compound being in racemic form or in the form of optical isomers, as well as the pharmaceutically acceptable acid addition salts thereof. The invention is suitable for use in drugs.

    Abstract translation: 本发明涉及具有式（I）的化合物，其中：R 1表示氢原子或选自环烷基，苄基和烷基，任选取代的基团; R2，R3，R4和R5各自表示氢原子或羟基，甲基，-OSO2R10，-OCOR10，任选取代的烷氧基，或R2和R3，或R3和R4，或R4和R5一起形成基团-O - （CH 2）q O - ， - O-CH = CH-O-或-O-CH = CH-; R6，R7，R8和R9各自表示氢原子或烷氧基，或R6和R7，或R7和R8，或R8和R9一起形成-O-（CH 2）q -O-基团; R10是选自直链或支链烷氧基C1-C6，NR11R11和选择取代的烷基; R 11和R 11各自表示氢原子或烷基，或R 11和R 11与具有相同形式的任选取代的单环或双环含氮杂环的氮原子一起形成; -X表示O，NH或CH 2; m和p各自表示0或1; n和q各自表示1或2，所述化合物为外消旋形式或以旋光异构体的形式，以及其药学上可接受的酸加成盐。 本发明适用于药物。

    NUEVO PROCEDIMIENTO DE SINTESIS DE IVABRADINA Y DE SUS SALES DE ADICION DE UN ACIDO FARMACEUTICAMENTE ACEPTABLE.
    8.
    发明专利
    NUEVO PROCEDIMIENTO DE SINTESIS DE IVABRADINA Y DE SUS SALES DE ADICION DE UN ACIDO FARMACEUTICAMENTE ACEPTABLE. 未知

    公开(公告)号：ES2373369T3

    公开(公告)日：2012-02-02

    申请号：ES10290166

    申请日：2010-03-30

    Applicant: SERVIER LAB

    Inventor： PEGLION JEAN-LOUIS ,  DESSINGES AIMEE ,  SERKIZ BERNARD

    IPC: C07D223/16

    Abstract: Procedimiento de síntesis del compuesto de fórmula (VII) en forma racémica u ópticamente activa: donde R representa un átomo de hidrógeno o un grupo metilo, caracterizado porque el compuesto de fórmula (VIII): se somete a reacción con el compuesto de fórmula (IX), en forma racémica u ópticamente activa, en forma de base libre o de sal: donde R tiene el significado arriba definido, en presencia de una sal de un metal de transición o de un lantánido, en un disolvente, para obtener el compuesto de fórmula (X), en forma racémica u ópticamente activa: que se transforma en el compuesto de fórmula (VII) mediante un agente donador de hidruro.

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