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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    82.
    发明专利
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 未知

    公开(公告)号：CA2856216C

    公开(公告)日：2021-01-12

    申请号：CA2856216

    申请日：2012-11-09

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  BHATTA PALLAVI ,  HEYWOOD SAM PHILIP ,  HUMPHREYS DAVID PAUL

    IPC: C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    proteína de fusão de anticorpo multivalente, e, ligação de albumina
    87.
    发明专利
    proteína de fusão de anticorpo multivalente, e, ligação de albumina 未知

    公开(公告)号：BR112012006492A2

    公开(公告)日：2016-11-22

    申请号：BR112012006492

    申请日：2010-09-24

    Applicant: UCB PHARMA SA

    Inventor： HANCOCK LAURA ,  ADAMS RALPH ,  HEYWOOD SAM PHILIP

    IPC: C07K16/24 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: proteína de fusão de anticorpo multivalente, e, ligação de albumina. uma proteína de fusão de anticorpo multivalente que compreende uma porçaõ de imunoglobina, por exemplo um fragmento de fab ou fab', com uma primeira especificidade para um antígeno de interesse, e compreende ainda dois anticorpos de domínio único (dab) com especificoidade para um segundo antígeno de interesse que são par vh/vl, em que os dois anticorpos de domínio único são ligados por uma ligação de dissulfeto. também são fornecidas proteínas de fusão de anticorpo de especificidade dual particulares e outros fragmentos de anticorpo que são estabilizados por uma ligação de dissulfeto.

    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    89.
    发明专利
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 未知

    公开(公告)号：IN3451DEN2014A

    公开(公告)日：2015-06-05

    申请号：IN3451DEN2014

    申请日：2014-04-30

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  BHATTA PALLAVI ,  HEYWOOD SAM PHILLIP ,  HUMPHREYS DAVID PAUL

    IPC: C07K16/18 ,  C07K16/28 ,  C07K16/46

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4 in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    Antibody molecules which bind il-17a and il-17f
    90.
    发明专利
    Antibody molecules which bind il-17a and il-17f 未知

    公开(公告)号：NZ613286A

    公开(公告)日：2014-11-28

    申请号：NZ61328612

    申请日：2012-01-11

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  BAKER TERENCE SEWARD ,  LAWSON ALASTAIR DAVID GRIFFITHS

    IPC: C07K16/24 ,  A61K39/395

    Abstract: Disclosed is a neutralising antibody which binds human IL-1 7A and human IL-17F having a light chain and a heavy chain wherein the variable domain of the light chain comprises the sequence AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTDFRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIK and the variable domain of the heavy chain comprises the sequence GFTFSDYNMA for CDR-H1, the sequence TITYEGRNTYYRDSVKG for CDR-H2 and the sequence PPQYYEGSIYRLWFAH for CDR-H3. Also disclosed is the use of such an antibody in the manufacture of a medicament for the treatment or prophylaxis of a pathological disorder that is mediated by IL-17A and/or IL-17F, or that is associated with an increased level of IL-17A and/or IL-17F.

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