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公开(公告)号：PL3068782T3
公开(公告)日：2018-12-31
申请号：PL14802788
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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公开(公告)号：RS57541B1
公开(公告)日：2018-10-31
申请号：RSP20180952
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
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公开(公告)号：CY1116277T1
公开(公告)日：2017-02-08
申请号：CY151100244
申请日：2015-03-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/12 , C07B43/04 , C07B57/00
Abstract: Ηεφεύρεσηαφοράσεμεθόδουςόπωςαυτέςπουδείχνονταιστοσχήμακαιενώσειςχρήσιμεςγιαπαρασκευήτροποποιημένωνπαραγώγωνασπαρτικούοξέος, όπωςχαρακτηριστικώνομάδωναλδεϋδηςασπαρτικούοξέος. Παράγωγαασπαρτικούοξέοςείναιχρήσιμαγιαπαρασκευήαναστολέωνκασπάσηςή/καιπροφαρμάκωναυτών.
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公开(公告)号：CA2843066C
公开(公告)日：2016-06-07
申请号：CA2843066
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/12 , C07B43/04 , C07B43/06 , C07B57/00 , C07C231/08 , C07K5/062
Abstract: The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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公开(公告)号：AU2014348752A1
公开(公告)日：2016-05-26
申请号：AU2014348752
申请日：2014-11-12
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , NUGENT WILLIAM ALOYSIUS , DVORNIKOVS VADIMS , ROSE PETER JAMISON
IPC: C07D471/04 , C07C51/083
Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
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Patent Agency Ranking
公开(公告)号：SI2399916T1
公开(公告)日：2015-05-29
申请号：SI200531941
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/00 , C07B43/04 , C07B57/00 , C07D405/12
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公开(公告)号：SI2399915T1
公开(公告)日：2015-05-29
申请号：SI200531945
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/00 , C07B43/00 , C07B43/04 , C07B57/00 , C07D405/12
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88.发明专利
公开(公告)号：PT1725548E
公开(公告)日：2015-04-16
申请号：PT05728092
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： NYCE PHILIP L , TANOURY GERALD J , CHEN MINZHANG , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R , JONES ANDREW D
IPC: C07D405/12 , C07B43/04 , C07B57/00
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89.发明专利
公开(公告)号：DK1725548T3
公开(公告)日：2015-03-23
申请号：DK05728092
申请日：2005-03-11
Applicant: VERTEX PHARMA
Inventor： TANOURY GERALD J , CHEN MINZHANG , JONES ANDREW D , NYCE PHILIP L , TRUDEAU MARTIN , GUERIN DAVID J , SNOONIAN JOHN R
IPC: C07D405/12 , C07B43/04 , C07B57/00
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公开(公告)号：AU2012201242B2
公开(公告)日：2014-06-12
申请号：AU2012201242
申请日：2012-03-01
Applicant: VERTEX PHARMA
Inventor： JONES ANDREW D , GUERIN DAVID J , TANOURY GERALD J , NYCE PHILIP L , TRUDEAU MARTIN , CHEN MINZHANG , SNOONIAN JOHN R
IPC: C07B43/04 , C07B57/00 , C07D405/12
Abstract: Processes and intermediates for the preparation of aspartic acetal caspase inhibitors Abstract The invention relates to processes such as that shown in the scheme and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde s moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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