公开(公告)号：LT3421468T

公开(公告)日：2021-01-11

申请号：LT18164040

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ,  DVORNIKOVS VADIMS ,  ROSE PETER

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：DK3068782T3

公开(公告)日：2018-08-13

申请号：DK14802788

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：DK3421468T3

公开(公告)日：2021-01-11

申请号：DK18164040

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：PL3068782T3

公开(公告)日：2018-12-31

申请号：PL14802788

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：RS57541B1

公开(公告)日：2018-10-31

申请号：RSP20180952

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

公开(公告)号：SG10201804021TA

公开(公告)日：2018-07-30

申请号：SG10201804021T

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD ,  NUGENT WILLIAM ,  DVORNIKOVS VADIMS ,  ROSE PETER

Abstract: METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate orphosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound(Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.

公开(公告)号：AU2014348752A1

公开(公告)日：2016-05-26

申请号：AU2014348752

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

Abstract: A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.

公开(公告)号：BR112016010576B1

公开(公告)日：2022-05-24

申请号：BR112016010576

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： GERALD J TANOURY ,  PETER JAMISON ROSE ,  DVORNIKOVS VADIMS ,  WILLIAM ALOYSIUS NUGENT

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61P31/16 ,  C07C51/083

Abstract: métodos de preparação de inibidores de replicação do vírus da gripe a presente invenção refere-se a um método de preparação (1) do composto (1) , ou de um sal farmaceuticamente aceitável do mesmo que compreende: (a) reagir o composto (x): (x) ou um sal farmaceuticamente aceitável do mesmo com o composto (y): (y) na presença de um catalisador de paládio e uma base de carbonato ou fosfato para formar o composto (z): (z) ou um sal farmaceuticamente aceitável do mesmo; e (b) desproteger o grupo ts do composto (z) para formar o composto (1), ou um sal farmaceuticamente aceitável do mesmo.

公开(公告)号：CY1121074T1

公开(公告)日：2019-12-11

申请号：CY181100876

申请日：2018-08-22

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/04 ,  C07C51/083

Abstract: ΜέθοδοςπαρασκευήςτηςΈνωσης (1) ήενόςφαρμακευτικώςαποδεκτούάλατοςαυτής: περιλαμβάνει: (α) αντίδρασητηςΈνωσης (Χ): ενόςφαρμακευτικώςαποδεκτούάλατοςαυτήςμετηνΈνωση (Υ): υπότηνπαρουσίαενόςκαταλύτηπαλλαδίουκαιμιαςανθρακικήςή φωσφορικήςβάσηςγιατονσχηματισμότηςΈνωσης (Ζ): ήενόςφαρμακευτικώςαποδεκτούάλατοςαυτής, και (β) αποπροστασίατης Ts ομάδαςτηςΈνωσης (Ζ) γιανασχηματιστείη Ένωση (1) ήέναφαρμακευτικώςαποδεκτόάλαςαυτής.

公开(公告)号：SI3068782T1

公开(公告)日：2018-10-30

申请号：SI201430850

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  NUGENT WILLIAM ALOYSIUS ,  DVORNIKOVS VADIMS ,  ROSE PETER JAMISON

IPC: C07D471/00 ,  C07C51/00