公开(公告)号：WO2014201088A1

公开(公告)日：2014-12-18

申请号：PCT/US2014/041863

申请日：2014-06-11

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： AKKUS, Ozan ,  SLIPCHENKO, Mikhail ,  AKKUS, Anna ,  YANG, Shan ,  LI, Bolan

IPC: G01J3/44 ,  G01N21/62 ,  G01N21/65 ,  G01N25/14

CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

Abstract translation: 用于确定某些化合物，特别是晶体是否存在于指示个体的生物流体样品中具有特定疾病或病症（例如但不限于痛风，假结肠或泌尿道结石）的方法。 在一些实施方案中，所述方法包括以下步骤：消化和过滤滑液样品，以便从样品中分离（如果存在的话）单酸一钠水溶液（MSU），焦磷酸钙二水合物（CPPD）或磷酸钙晶体，其中 用拉曼装置分析滤液以确定晶体的存在和类型。 公开了用于执行该方法的步骤的装置。

公开(公告)号：WO2014130970A2

公开(公告)日：2014-08-28

申请号：PCT/US2014/018110

申请日：2014-02-24

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： CHEN, Mingsong ,  AGUANNO, Mauro ,  BOO, Kuan Moon ,  SOH, Woon Liang Terence ,  FREUDENTHAL, Jacob ,  MARKS, Jeffrey

IPC: G01N21/27

CPC classification number: G01N21/6486 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2201/061 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/121

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样品保持器被仪器保持时产生第一目标温度，并且当第二样品保持器被仪器保持时产生第二目标温度。

公开(公告)号：WO2013039587A2

公开(公告)日：2013-03-21

申请号：PCT/US2012/044054

申请日：2012-06-25

Applicant: NORTHEASTERN UNIVERSITY ,  DIEM, Max ,  BIRD, Benjamin ,  MILJKOVIC, Milos

Inventor： DIEM, Max ,  BIRD, Benjamin ,  MILJKOVIC, Milos

IPC: G06F19/00

CPC classification number: G01N21/255 ,  G01J3/28 ,  G01N21/1702 ,  G01N21/31 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N2201/10 ,  G01N2201/121

Abstract: Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed.

Abstract translation: 本文公开了一种校正光谱的反射失真的过程和系统。 此外，公开了补偿反射失真的光谱系统。

公开(公告)号：WO2012093028A1

公开(公告)日：2012-07-12

申请号：PCT/EP2011/073239

申请日：2011-12-19

Applicant: HACH LANGE GMBH ,  STEFAN, Frank

Inventor： STEFAN, Frank

IPC: G01B11/08 ,  G01N21/90 ,  G01N21/25 ,  G01N35/00 ,  B01L3/00

CPC classification number: G01B11/24 ,  B01L3/5082 ,  B01L2200/143 ,  B01L2300/021 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0832 ,  B01L2300/0858 ,  G01B11/08 ,  G01B11/12 ,  G01N21/03 ,  G01N21/251 ,  G01N21/274 ,  G01N21/5911 ,  G01N35/00732 ,  G01N2201/121

Abstract: Die Erfindung bezieht sich auf ein Verfahren zur Ermittlung eines Formkorrekturwertes F für Labor-Flüssigkeitsanalyse-Küvetten (10) mit einem im Querschnitt kreisrunden Kuvettenkörper (12) für die fotometrische Flüssigkeitsanalyse, und sieht folgende Verfahrensschritte vor: optisches Messen des Innen- oder Außen-Durchmessers d 1 ;d 0 des Küvettenkörpers (12), Errechnen eines Formkorrekturwertes F aus dem vermessenen Küvettenkörper- Durchmesser d 1 ;d 0 , und Hinterlegung des Formkorrekturwertes F an dem Küvettenkörper (12).

Abstract translation: 本发明涉及一种方法，用于确定具有一个圆形横截面Kuvettenkörper（12），用于光度流体分析实验室流体分析比色皿的形状修正值F（10），并提供了以下的方法步骤：在内径或外径的光学测量 所述Küvettenkörpers（12）的D1 D0，计算从所述测量Küvettenkörper-径d1的形状修正值F; D0，和在比色皿（12）的形状修正值F的存款。

公开(公告)号：WO2010124685A3

公开(公告)日：2011-03-03

申请号：PCT/DE2010050018

申请日：2010-04-14

Applicant: CAREFUSION GERMANY 234 GMBH ,  SCHERER HELMUT ,  SCHRADER DIETER ,  MENNINGER STEFAN

Inventor： SCHERER HELMUT ,  SCHRADER DIETER ,  MENNINGER STEFAN

IPC: G01N21/27 ,  G01N21/35 ,  G01N21/39 ,  G01N21/61

CPC classification number: G01N21/39 ,  G01J1/42 ,  G01J1/4257 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/61 ,  G01N21/8507 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/121 ,  G01N2201/1245 ,  G01N2201/12753

Abstract: The invention relates to an actuation and evaluation circuit for a laser diode (1) and a photodiode (3) for determining the concentration of a gas. The laser diode, for example a variable frequency semi-conductor laser in the form of a DFB semi-conductor laser, can generate light in the range of an absorption line of the gas. The circuit comprises a driver (10, 11, 12, 13) for generating a driver signal (17) for the laser diode (1), an assembly (8, 9) for generating a reference signal (20), and a subtractor (5) for subtracting the reference signal (20) from the signal (21) supplied by the photodiode, in order to compensate the non-linear characteristic lines of the semi-conductor laser. The invention further relates to a measuring device for determining the concentration of a gas by way of such an actuation and evaluation circuit. Finally, the invention relates to a corresponding method.

Abstract translation: 本发明涉及一种驱动和评价电路用于激光二极管（1）和用于确定气体的浓度的光电二极管（3）。 的激光二极管，例如 在DFB半导体激光器的形式的可调半导体激光器所用的气体的吸收线的范围内产生光。 该电路包括用于激光二极管生成的驱动信号（17）（1），一个组件的驱动器（10，11，12，13）（8,9），用于产生参考信号（20）和用于减去的减法器（5） 从由光电二极管信号（21）提供的信号的基准信号（20）以补偿所述半导体激光器的非线性特性。 此外，本发明涉及一种测量装置，用于确定气体的浓度与这样的控制和评估电路。 最后，本发明涉及一种相应的方法。

公开(公告)号：WO1988002890A1

公开(公告)日：1988-04-21

申请号：PCT/US1987002758

申请日：1987-10-16

Applicant: NELLCOR, INC.

Inventor： NELLCOR, INC. ,  CORENMAN, James, E. ,  GOLDBERGER, Daniel, S. ,  BRAIG, James, R. ,  ROJAS, Emil, P. ,  RICHARDS, Edward, M. ,  GALLUP, David, A.

IPC: G06F15/46

CPC classification number: A61B5/083 ,  G01N21/3504 ,  G01N21/61 ,  G01N2021/3129 ,  G01N2201/121

Abstract: An improved gas analyzer system and method for detecting and displaying the constituent gases of a respiratory gas stream, the system comprising an optical bench (109) comprising a gas pathway for the flow of a gas stream, a flow shaping inlet, three infrared detection channel assemblies for measuring the partial pressures of constituent gases, and measuring sensitivity changes in the detectors of the three infrared detection channel assemblies, a pressure sensor for measuring the pressure within the gas pathway, a temperature sensor for measuring the temperature within the optical bench, a flow rate sensor for measuring the gas flow rate through the gas pathway; analog processing circuitry (124) for processing the detected partial gas pressures, sensitivity changes, the measured values for pressure, temperature, and flow rate, and display processing circuitry (128).

Abstract translation: 一种用于检测和显示呼吸气流的气体成分的改进的气体分析系统和方法，所述系统包括：光学工作台（109），其包括用于气流的循环路径， 流，三套红外线检测通道的测量气体成分的分压和在三组红外线检测通道，压力计用于测量压力的探测器的灵敏度测量变化的调制 气路，用于测量光学平台中的温度的温度计，用于测量气体路径中的气体流量的流量计，用于处理检测到的分压的模拟处理电路（124），灵敏度变化， 压力，温度和流量的测量值以及用于显示的处理电路（128）。

公开(公告)号：US20240255436A1

公开(公告)日：2024-08-01

申请号：US18104231

申请日：2023-01-31

Applicant: Applied Materials Israel Ltd.

Inventor： Mariano ABRAMSON ,  Uzi BARAZANI ,  Menachem LAPID

IPC: G01N21/88 ,  G01N21/95 ,  G02B21/02 ,  G02B21/12 ,  G02B21/18 ,  G02B27/00

CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G02B21/02 ,  G02B21/125 ,  G02B21/18 ,  G02B27/0012 ,  G01N2201/0636 ,  G01N2201/121

Abstract: A wafer inspection tool comprising an illumination system having: a field of view (FOV); a light source pupil having a size and shape; a central optical axis; and one or more field angle defining a shape of said FOV extending away from said light source pupil; an objective lens arrangement including an objective and a plurality of interchangeable telescopes coupled thereto, the objective lens arrangement being configured to collect light reflected off a plurality of field points on the wafer and to onwardly transmit a light beam formed from the collected light; and a light separator having a first reflective surface with a transmissive region formed therein and a second surface, wherein said transmissive region is arranged to allow therethrough a central portion of said light beam transmitted from said objective lens arrangement corresponding to the brightfield channel while said reflective surface is arranged to reflect a peripheral portion of said light beam transmitted from said objective lens arrangement corresponding to the darkfield channel; a relay module configured to relay said light source pupil to said transmissive region; wherein said transmissive region has a shape defined as a geometric intersection volume between a model of said illumination light and said reflective surface and said second surface; wherein said model includes a plurality of solids each solid having a cross section of said light source pupil and angled to a field angle of said one or more field angle.

公开(公告)号：US20240175807A1

公开(公告)日：2024-05-30

申请号：US18071690

申请日：2022-11-30

Applicant: Aikemy Gmbh

Inventor： Kotaro ISHIZAKI ,  Agata Dorota ISHIZAKI-SROKA

IPC: G01N21/27

CPC classification number: G01N21/274 ,  G01N2201/121

Abstract: A device for analyzing a sample includes a measurement area at which the sample is to be located, an illumination arrangement, and first and second spectral sensors. The illumination arrangement illuminates the measurement area such that the illumination is incident on the sample. Each of the first and second spectral sensors is oriented toward the measurement area to collect illumination arriving from the measurement area. The first spectral sensor performs a spectral measurement of the sample in response to the incident illumination so as to produce spectral measurement data. The second spectral sensor measures background noise so as to produce background measurement data that provides at least a partial correction for noise in the spectral measurement data. In certain embodiments, operation of the first and second spectral sensors is switched such that the second spectral sensor performs a spectral measurement and the first spectral sensor measures background noise.

公开(公告)号：US20240096667A1

公开(公告)日：2024-03-21

申请号：US18272859

申请日：2021-01-29

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Hiromichi YAMAKAWA ,  Toshifumi HONDA ,  Yuta URANO ,  Shunichi MATSUMOTO ,  Masaya YAMAMOTO ,  Eiji ARIMA

IPC: H01L21/67 ,  G01N21/95 ,  G06T7/60 ,  G06T7/70

CPC classification number: H01L21/67288 ,  G01N21/9501 ,  G06T7/60 ,  G06T7/70 ,  G01N2201/103 ,  G01N2201/1087 ,  G01N2201/121 ,  H04N23/67

Abstract: A defect inspection device in which an optical axis of a detection optical system is inclined with respect to a surface of a sample, and an imaging sensor is inclined with respect to the optical axis, a height variation amount of an illumination spot in a normal direction of the surface of the sample is calculated based on an output of a height measuring unit, a deviation amount of the focusing position with respect to the light receiving surface in an optical axis direction of the detection optical system is calculated based on the height variation amount of the illumination spot, the deviation amount of the focusing position being generated accompanying a height variation of the illumination spot, and the focus actuator is controlled based on the deviation amount of the focusing position, and scattered light intensities at the same coordinates of the sample are added.

公开(公告)号：US20240060898A1

公开(公告)日：2024-02-22

申请号：US18452060

申请日：2023-08-18

Applicant: Carl Zeiss Microscopy GmbH

Inventor： Stanislav Kalinin ,  Dieter Huhse

IPC: G01N21/64 ,  G02B21/16

CPC classification number: G01N21/6486 ,  G02B21/16 ,  G01N2201/121

Abstract: A method can be used for correcting background signals in captured measurement values of analog detectors, wherein measurement values of an object captured over a reference time period are analyzed and characteristic values of captured background signals are determined. What is characteristic of this is that a threshold value is determined on the basis of at least one characteristic value and by applying a calculation specification; the threshold value is applied to captured measurement values of an analog detector, and only those measurement values which are greater than the threshold value are used for a subsequent signal evaluation. A microscope for carrying out the method according to the invention is also provided.