公开(公告)号：WO2012009699A3

公开(公告)日：2012-03-15

申请号：PCT/US2011044283

申请日：2011-07-15

Applicant: ABBOTT LAB ,  SHEKHAR SHASHANK ,  FRANCZYK THADDEUS S ,  BARNES DAVID M ,  DUNN TRAVIS B ,  HAIGHT ANTHONY R ,  CHAN VINCENT S

Inventor： SHEKHAR SHASHANK ,  FRANCZYK THADDEUS S ,  BARNES DAVID M ,  DUNN TRAVIS B ,  HAIGHT ANTHONY R ,  CHAN VINCENT S

IPC: C07D239/54 ,  A61K31/522 ,  A61P31/14 ,  B01J31/24

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K31/7056 ,  A61K38/21 ,  A61K45/06 ,  B01J31/2423 ,  B01J2231/344 ,  B01J2231/4227 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2231/4294 ,  B01J2531/824 ,  A61K2300/00

Abstract: This disclosure is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

Abstract translation: 本公开涉及：（a）制备其特别是可用于抑制丙型肝炎病毒（HCV）的化合物及其盐的方法; （b）可用于制备化合物和盐的中间体; （c）包含该化合物或其盐的药物组合物; 和（d）使用这种组合物的方法。

公开(公告)号：WO2006042034A3

公开(公告)日：2006-04-20

申请号：PCT/US2005/036024

申请日：2005-10-09

Applicant: ABBOTT LABORATORIES ,  ZHANG, Geoff, G. ,  BRADLEY, Michael, F. ,  BARNES, David, M. ,  HENRY, Rodger

Inventor： ZHANG, Geoff, G. ,  BRADLEY, Michael, F. ,  BARNES, David, M. ,  HENRY, Rodger

IPC: C07D401/14

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

公开(公告)号：WO2006042034A2

公开(公告)日：2006-04-20

申请号：PCT/US2005/036024

申请日：2005-10-09

Applicant: ABBOTT LABORATORIES ,  ZHANG, Geoff, G. ,  BRADLEY, Michael, F. ,  BARNES, David, M. ,  HENRY, Rodger

Inventor： ZHANG, Geoff, G. ,  BRADLEY, Michael, F. ,  BARNES, David, M. ,  HENRY, Rodger

CPC classification number: C07D401/14 ,  A61K31/4709 ,  A61K47/02 ,  A61K47/12 ,  C07C31/26

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract translation: 公开了药物的结晶形式，制备方法，含有它的组合物以及治疗疾病和抑制不利生理事件的方法。

公开(公告)号：WO2012150994A1

公开(公告)日：2012-11-08

申请号：PCT/US2012/027027

申请日：2012-02-28

Applicant: CUMMINS INTELLECTUAL PROPERTY, INC. ,  BARNES, David, M.

Inventor： BARNES, David, M.

IPC: F02G5/00

CPC classification number: F01P3/2285 ,  F01P3/16 ,  F02F1/40 ,  F02G5/00 ,  F02M31/14 ,  Y02T10/126 ,  Y02T10/166

Abstract: A waste heat recovery system connects a working fluid into passages formed within an internal combustion engine. The fluid passages transport the working fluid to high temperature areas of the engine, raising the temperature of the working fluid near the phase change point or above the phase change point. The heated working fluid drives an energy conversion portion located downstream from the engine. The heat absorbed by the working fluid decreases the load on an engine cooling system as well as driving an energy conversion portion, improving fuel efficiency.

Abstract translation: 废热回收系统将工作流体连接到内燃机内形成的通道中。 流体通道将工作流体输送到发动机的高温区域，提高工作流体在相变点附近或相变点附近的温度。 加热的工作流体驱动位于发动机下游的能量转换部分。 工作流体吸收的热量减少了发动机冷却系统的负载，同时驱动能量转换部分，提高燃油效率。

公开(公告)号：WO2005110385A1

公开(公告)日：2005-11-24

申请号：PCT/US2005/011787

申请日：2005-04-06

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  OAKS, John, A. ,  BASS, Paul ,  BARNES, David, M. ,  ZIMMERMAN, Noah, P.

Inventor： OAKS, John, A. ,  BASS, Paul ,  BARNES, David, M. ,  ZIMMERMAN, Noah, P.

IPC: A61K31/00

CPC classification number: A61K31/00 ,  A61K9/0053 ,  A61K9/0095 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  A61K2300/00

Abstract: The present invention provides methods and compositions for slowing the transit time of foodstuffs, pharmaceutical compounds, nutritional supplements, and vitamins through the gastrointestinal tract using cyclic Gulp (cGMP) alone and cGMP in combination with succinate. The method and corresponding compositions prolong residence time of such compounds, and thereby increase absorption through the small intestine, increase bioavailability, and improve feed conversion ratios.

Abstract translation: 本发明提供了使用单独的环状GMP（cGMP）和cGMP与琥珀酸酯组合来减缓食品，药物化合物，营养补充剂和维生素通过胃肠道的通过时间的方法和组合物。 该方法和相应的组合物延长了这些化合物的停留时间，从而增加了通过小肠的吸收，提高了生物利用度，并提高了饲料转化率。

公开(公告)号：WO2012154821A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037079

申请日：2012-05-09

Applicant: CUMMINS, INC. ,  BARNES, David, M.

Inventor： BARNES, David, M.

IPC: B60K6/00

CPC classification number: B60K6/48 ,  Y02T10/6221 ,  Y10T74/19126

Abstract: One embodiment of the present Invention is a unique vehicle having a hybrid drive system. Other embodiments include unique hybrid drive systems, Still other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for fluid driven actuation systems. Further embodiments, forms, features, aspects, benefits, and advantages of the present application shall become apparent from the description and figures provided herewith.

Abstract translation: 本发明的一个实施例是具有混合驱动系统的独特车辆。 其它实施例包括独特的混合驱动系统。其它实施例包括用于流体驱动致动系统的装置，系统，装置，硬件，方法和组合。 本申请的其他实施例，形式，特征，方面，益处和优点将从本文提供的描述和图中变得显而易见。

公开(公告)号：WO2012009698A1

公开(公告)日：2012-01-19

申请号：PCT/US2011/044282

申请日：2011-07-15

Applicant: ABBOTT LABORATORIES ,  SHEKHAR, Shashank ,  FRANCZYK, Thaddeus S. ,  BARNES, David M. ,  DUNN, Travis B. ,  HAIGHT, Anthony R. ,  CHAN, Vincent S.

Inventor： SHEKHAR, Shashank ,  FRANCZYK, Thaddeus S. ,  BARNES, David M. ,  DUNN, Travis B. ,  HAIGHT, Anthony R. ,  CHAN, Vincent S.

IPC: B01J31/24

CPC classification number: C07F9/657163 ,  B01J31/189 ,  B01J31/2423 ,  B01J31/2466 ,  B01J31/2485 ,  B01J31/249 ,  B01J2231/344 ,  B01J2231/4227 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2231/4294 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/0288 ,  B01J2531/824 ,  B01J2540/10 ,  B01J2540/40 ,  C07C1/30 ,  C07C1/321 ,  C07C15/14 ,  C07C17/093 ,  C07C17/361 ,  C07C41/09 ,  C07C45/68 ,  C07C201/10 ,  C07C253/30 ,  C07C273/1854 ,  C07C273/1863 ,  C07C303/40 ,  C07C315/04 ,  C07C319/14 ,  C07C319/18 ,  C07C2523/42 ,  C07C2523/44 ,  C07C2523/46 ,  C07C2523/52 ,  C07C2523/72 ,  C07C2523/75 ,  C07C2523/755 ,  C07C2527/14 ,  C07C2531/22 ,  C07C2531/24 ,  C07D209/34 ,  C07D239/54 ,  C07D295/033 ,  C07F5/027 ,  C07F9/40 ,  C07F9/65036 ,  C07F9/65515 ,  C07F9/6552 ,  C07F9/65683 ,  C07F9/6571 ,  C07F9/6584 ,  Y02P20/52 ,  C07C275/28 ,  C07C311/08 ,  C07C311/21 ,  C07C311/29 ,  C07C255/10 ,  C07C321/30 ,  C07C205/45 ,  C07C15/06 ,  C07C49/784 ,  C07C25/18

Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.

Abstract translation: 本公开涉及：（a）磷酸基配体; （b）在成键反应中使用这种磷酸基配体的方法; 和（c）制备磷酸基配体的方法。

公开(公告)号：WO2010096432A2

公开(公告)日：2010-08-26

申请号：PCT/US2010024405

申请日：2010-02-17

Applicant: CUMMINS INC ,  BARNES DAVID M ,  CECIL ADAM C

Inventor： BARNES DAVID M ,  CECIL ADAM C

IPC: F01L13/00 ,  F01L1/04 ,  F01L1/18 ,  F02D13/02

CPC classification number: F01L13/0047 ,  F01L1/08 ,  F01L1/181 ,  F01L1/267 ,  F01L1/344 ,  F01L2105/00 ,  F01L2800/10 ,  F02D13/0269 ,  F02D2013/0292 ,  F02M26/01 ,  Y02T10/142

Abstract: A variable valve actuation system is disclosed, in one form a rocker is disclosed coupled with a valve stem at one end and a cam follower at the other end. The rocker is operable to pivot about a fixed axis. The cam follower is operable to be pivotally coupled with the rocker at one end of the cam follower. The cam follower includes a lower roller and an upper roller at its other end, each operable to engage cam lobes on separate cam shafts. In one form the cam follower includes a lower roller operable to follow a cam lobe on a lower cam shaft and an upper roller operable to follow a cam lobe on an upper cam shaft. The upper cam shaft and the lower cam shaft can have variable lobes. A spring can be used to bias the cam follower on the rocker.

Abstract translation: 公开了一种可变气门致动系统，以一种形式公开了一种摇臂，其一端连接有阀杆，另一端连接有凸轮从动件。 摇杆可操作以围绕固定轴线枢转。 凸轮从动件可操作以在凸轮从动件的一端处与摇杆枢转地联接。 凸轮从动件在其另一端包括下辊和上辊，每个可操作以接合分离的凸轮轴上的凸轮凸角。 在一种形式中，凸轮从动件包括可操作成跟随下凸轮轴上的凸轮凸角的下辊和可操作以跟随上凸轮轴上的凸轮凸角的上辊。 上凸轮轴和下凸轮轴可以具有可变凸角。 可以使用弹簧将凸轮从动件偏置在摇杆上。

公开(公告)号：WO2009039135A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076594

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  DONNER, Pamela L. ,  RANDOLPH, John T. ,  KRUEGER, Allan C. ,  BETEBENNER, David A. ,  HUTCHINSON, Douglas K. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton L. ,  MARING, Clarence J. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  ZHANG, Geoff G. Z.

Inventor： DONNER, Pamela L. ,  RANDOLPH, John T. ,  KRUEGER, Allan C. ,  BETEBENNER, David A. ,  HUTCHINSON, Douglas K. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton L. ,  MARING, Clarence J. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  ZHANG, Geoff G. Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D239/553 ,  A61K31/513 ,  A61K31/506 ,  A61P31/14

CPC classification number: C07D239/22 ,  A61K31/513 ,  C07D239/54 ,  C07D239/553 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are usefull in the treatment of hepatitis C and are of the following general structure: Formula (I)

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。 该化合物在丙型肝炎的治疗中是有用的，具有以下通用结构：式（I）

公开(公告)号：WO2018063979A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/053216

申请日：2017-09-25

Applicant: CECIL, Adam C. ,  BARNES, David M.

Inventor： CECIL, Adam C. ,  BARNES, David M.

IPC: F01L1/18 ,  F01L1/04 ,  F01L1/24 ,  F01L1/26 ,  F01L9/02

Abstract: A valve train assembly (16) includes a fuel injector (1), an intake rocker lever assembly (10), and an exhaust rocker lever assembly (14). The intake and exhaust rocker lever assemblies (10) can include an eccentric hydraulic lash adjuster (11) that is located in the nose (31) of the respective rocker lever assemblies (10). The rocker lever assemblies (10) are configured to allow a clearance area between a nose (31) of the intake rocker lever assembly (10) and the nose (31) of the exhaust rocker lever assembly (14). As such, the fuel injector (1) can be positioned in the clearance area, while still allowing the eccentric hydraulic lash adjusters to apply a load onto a corresponding valve bridge (2). For example, the eccentric hydraulic lash adjuster (11) can include an outer housing (20) and a pivot ball (21), wherein the pivot ball (21) is positioned at an offset (23) from a lateral centerline of the outer housing (20).

Abstract translation: 气门组件（16）包括燃料喷射器（1），进气摇杆组件（10）和排气摇杆组件（14）。 进气和排气摇杆组件（10）可以包括位于相应摇杆组件（10）的突出部（31）中的偏心液压间隙调节器（11）。 摇杆组件（10）构造成允许进气摇杆组件（10）的突出部（31）和排气摇杆组件（14）的突出部（31）之间的间隙区域。 这样，燃料喷射器（1）可以定位在间隙区域中，同时仍允许偏心液压间隙调节器将载荷施加到对应的阀桥（2）上。 例如，偏心液压间隙调节器（11）可以包括外壳（20）和枢轴球（21），其中枢轴球（21）定位在与外壳的侧向中心线偏离 （20）。