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    METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES
    5.
    发明申请
    METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES 审中-公开
    治疗和检测MISDOLD-SOD1介导的疾病的方法和组合

    公开(公告)号：WO2007098607A8

    公开(公告)日：2016-10-27

    申请号：PCT/CA2007000346

    申请日：2007-03-05

    Applicant: AMORFIX LIFE SCIENCES LTD ,  UNIV HEALTH NETWORK ,  CASHMAN NEIL R ,  CHAKRABARTTY AVIJIT ,  RAKHIT RISHI ,  OSTERMAN JOACHIM BERNHARD

    Inventor： CASHMAN NEIL R ,  CHAKRABARTTY AVIJIT ,  RAKHIT RISHI ,  OSTERMAN JOACHIM BERNHARD

    IPC: C12N15/53 ,  A61K31/7088 ,  A61K38/44 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P25/28 ,  C07K16/40 ,  C12N5/12 ,  C12N9/02 ,  G01N33/573

    CPC classification number: C07K16/40 ,  A01K2267/0312 ,  A01K2267/0318 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/0005 ,  A61K39/0007 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/575 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/90283 ,  G01N2800/2828

    Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

    Abstract translation: 本发明提供了在需要治疗的受试者中治疗由错误折叠形式的超氧化物歧化酶（SOD）介导的医学病症，疾病或病症的方法。 所述方法任选包括向受试者施用包含药学上可接受的载体和选自（1）选择性结合SOD的错误折叠形式的外源性抗体或其片段的组合物，和/或（2）引起生产的免疫原 选择性结合SOD的错误折叠形式的内源性抗体，和/或（3）编码（1）或（2）的核酸序列。 在某些实施方案中，本发明提供了使用肌萎缩性疾病特异性表位治疗疾病如阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法，以及包括这些表位的组合物。 本发明还提供结合单体或错折叠的SOD1，而不是在天然同二聚体SOD1的分子表面上的抗体。 此外，本发明包括在受试者中诊断阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法。 此外，本发明提供了鉴定用于治疗或预防阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的物质以及使用本发明的结合蛋白的试剂盒的方法。

    METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES
    8.
    发明申请
    METHODS AND COMPOSITIONS TO TREAT AND DETECT MISFOLDED-SOD1 MEDIATED DISEASES 审中-公开
    治疗和检测MISDOLD-SOD1介导的疾病的方法和组合

    公开(公告)号：WO2007098607A1

    公开(公告)日：2007-09-07

    申请号：PCT/CA2007/000346

    申请日：2007-03-05

    Applicant: AMORFIX LIFE SCIENCES LTD. ,  UNIVERSITY HEALTH NETWORK ,  CASHMAN, Neil, R. ,  CHAKRABARTTY, Avijit ,  RAKHIT, Rishi ,  OSTERMAN, Joachim, Bernhard

    Inventor： CASHMAN, Neil, R. ,  CHAKRABARTTY, Avijit ,  RAKHIT, Rishi ,  OSTERMAN, Joachim, Bernhard

    IPC: C12N15/53 ,  A61K31/7088 ,  A61K38/44 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P25/28 ,  C07K16/40 ,  C12N5/12 ,  C12N9/02 ,  G01N33/573

    CPC classification number: C07K16/40 ,  A01K2267/0312 ,  A01K2267/0318 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/0005 ,  A61K39/0007 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/575 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/6896 ,  G01N2333/90283 ,  G01N2800/2828

    Abstract: The invention provides a method for treating a medical condition, disease, or disorder mediated by a misfolded form of superoxide dismutase (SOD) in a subject in need of treatment. The method optionally comprises administering to the subject a composition comprising a pharmaceutically acceptable vehicle and an agent selected from (1) an exogenous antibody or fragment thereof that binds selectively to the misfolded form of SOD, and/or (2) an immunogen that elicits production of an endogenous antibody that binds selectively to the misfolded form of SOD, and/or (3) a nucleic acid sequence encoding (1) or (2). In certain embodiments, the invention provides methods of treating diseases such as Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis using amyotrophic disease-specific epitopes, and compositions including these epitopes. The invention also provides antibodies that bind to monomeric or misfolded SOD1, and not on the molecular surface of native homodimeric SOD1. In addition, the invention includes methods of diagnosing Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis in a subject. Also, the invention provides methods of identifying substances for the treatment or prevention of Alzheimer's Disease, Parkinson's Disease or amyotrophic lateral sclerosis and kits using the binding proteins of the invention.

    Abstract translation: 本发明提供了在需要治疗的受试者中治疗由错误折叠形式的超氧化物歧化酶（SOD）介导的医学病症，疾病或病症的方法。 所述方法任选包括向受试者施用包含药学上可接受的载体和选自（1）选择性结合SOD的错误折叠形式的外源性抗体或其片段的组合物，和/或（2）引起生产的免疫原 选择性结合SOD的错误折叠形式的内源性抗体，和/或（3）编码（1）或（2）的核酸序列。 在某些实施方案中，本发明提供了使用肌萎缩性疾病特异性表位治疗疾病如阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法，以及包括这些表位的组合物。 本发明还提供结合单体或错折叠的SOD1，而不是在天然同二聚体SOD1的分子表面上的抗体。 此外，本发明包括在受试者中诊断阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的方法。 此外，本发明提供了鉴定用于治疗或预防阿尔茨海默病，帕金森病或肌萎缩性侧索硬化的物质以及使用本发明的结合蛋白的试剂盒的方法。

    PROTEIN AGGREGATION ASSAYS AND USES THEREOF
    9.
    发明申请
    PROTEIN AGGREGATION ASSAYS AND USES THEREOF 审中-公开
    蛋白质聚集测定及其用途

    公开(公告)号：WO03000853A2

    公开(公告)日：2003-01-03

    申请号：PCT/US0219836

    申请日：2002-06-20

    Applicant: CAPRION PHARMACEUTICALS INC ,  KONDEJEWSKI LES ,  CHAKRABARTTY AVIJIT ,  QI XIAO-FEI ,  CASHMAN NEIL

    Inventor： KONDEJEWSKI LES ,  CHAKRABARTTY AVIJIT ,  QI XIAO-FEI ,  CASHMAN NEIL

    IPC: G01N33/68 ,  C12N

    CPC classification number: G01N33/6896

    Abstract: This invention features methods for identifying agents that modulate protein aggregation or stabilize protein conformation. Exemplary methods include an in vitro aggregation assay, a native state stabilization assay, a cell-based screening assay, and an animal-based screening assay. These methods can be used to identify agents useful for the treatment of conformational diseases resulting from aggregation of a protein.

    Abstract translation: 本发明描述了鉴定调节蛋白质聚集或稳定蛋白质构象的试剂的方法。 示例性的方法包括体外聚集测定法，天然状态稳定测定法，基于细胞的筛选测定法和基于动物的筛选测定法。 这些方法可以用于鉴定用于治疗由蛋白质聚集引起的构象疾病的药剂。

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