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    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES
    3.
    发明申请
    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES 审中-公开
    新的绿色和橙色荧光标签及其用途

    公开(公告)号：WO2004027388A3

    公开(公告)日：2004-06-10

    申请号：PCT/US0330167

    申请日：2003-09-23

    Applicant: CHROMAGEN INC ,  BHATT RAM ,  CONRAD MICHAEL J ,  BENCHEIKH AZZOUZ ,  XIONG YIFENG

    Inventor： BHATT RAM ,  CONRAD MICHAEL J ,  BENCHEIKH AZZOUZ ,  XIONG YIFENG

    IPC: C07C309/50 ,  C07C309/51 ,  C07C311/29 ,  C07C331/20 ,  C07D207/44 ,  C07D207/452 ,  C07D207/46 ,  G01N33/533 ,  C07C309/63 ,  A61K31/10

    CPC classification number: C07D207/46 ,  C07C309/50 ,  C07C309/51 ,  C07C311/29 ,  C07C331/20 ,  C07C2603/50 ,  C07D207/452 ,  G01N33/533 ,  Y10S436/80

    Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

    Abstract translation: 本发明提供了新颖的荧光化合物和共价连接化学物质，其有利于使用这些化合物作为标记用于超低灵敏度和定量荧光检测低水平生物分子。 在一个优选的实施方案中，本发明的荧光标记是羟基芘三磺酸和二磺酸的新衍生物，其可用于任何其中目前使用放射​​性同位素，有色染料或其他荧光分子的测定中。 因此，例如，使用标记抗体，蛋白质，寡核苷酸或脂质（包括荧光细胞分选，荧光显微术（包括暗视野显微术），荧光偏振测定，配体，受体结合测定，受体活化测定和诊断测定）的任何测定可以受益 从使用本文公开的化合物。

    NOVEL CHEMISTRIES, SOLUTIONS, AND DISPERSAL SYSTEMS FOR DECONTAMINATION OF CHEMICAL AND BIOLOGICAL SYSTEMS
    4.
    发明申请
    NOVEL CHEMISTRIES, SOLUTIONS, AND DISPERSAL SYSTEMS FOR DECONTAMINATION OF CHEMICAL AND BIOLOGICAL SYSTEMS 审中-公开
    用于化学和生物系统去除的新型化学，解决方案和分散体系

    公开(公告)号：WO2010059459A1

    公开(公告)日：2010-05-27

    申请号：PCT/US2009/063840

    申请日：2009-11-10

    Applicant: CONRAD, Michael, J. ,  ARIES ASSOCIATES, INC.

    Inventor： CONRAD, Michael, J.

    IPC: C02F1/72

    CPC classification number: C02F1/66 ,  C02F1/722 ,  C02F1/725 ,  C02F2101/30 ,  C02F2303/04 ,  C02F2305/02 ,  C02F2305/04 ,  Y02W10/37

    Abstract: The present invention relates generally to chemical and biological decontamination solutions and methods of using them. The invention is useful for decontaminating and/or disinfecting a wide range of compounds and organisms. In particular, the systems, methods, solutions, and formulations of the invention can be used to remove and/or neutralize organophosphates, mustard agents, and other toxic chemicals, bacteria, bacterial spores, fungi, molds and viruses.

    Abstract translation: 本发明一般涉及化学和生物净化方法及其使用方法。 本发明可用于对各种化合物和生物进行净化和/或消毒。 特别地，本发明的系统，方法，溶液和制剂可用于去除和/或中和有机磷酸盐，芥子剂和其它有毒化学物质，细菌，细菌孢子，真菌，霉菌和病毒。

    HOMOGENEOUS AND HETEROGENEOUS ASSAY METHODS USING NUCLEATION CENTERS AND NOVEL COVALENT CHEMISTRIES FOR THE RAPID MEASUREMENT OF PHOSPHORYLATION AND DE-PHOSPHORYLATION
    5.
    发明申请
    HOMOGENEOUS AND HETEROGENEOUS ASSAY METHODS USING NUCLEATION CENTERS AND NOVEL COVALENT CHEMISTRIES FOR THE RAPID MEASUREMENT OF PHOSPHORYLATION AND DE-PHOSPHORYLATION 审中-公开
    使用核化中心和新颖的合成化学品进行均相和异质性测定方法，用于快速测定磷化氢和脱磷酸

    公开(公告)号：WO2004089295A2

    公开(公告)日：2004-10-21

    申请号：PCT/US2004/010289

    申请日：2004-04-01

    Applicant: CHROMAGEN, INC. ,  BHATT, Ram, S. ,  MILLER-WING, Allison, V. ,  HELMS, Rebecca ,  GESSERT, Steve ,  GONZALES, Frank ,  CONRAD, Michael, J.

    Inventor： BHATT, Ram, S. ,  MILLER-WING, Allison, V. ,  HELMS, Rebecca ,  GESSERT, Steve ,  GONZALES, Frank ,  CONRAD, Michael, J.

    IPC: A61K

    CPC classification number: C07K17/14 ,  C07K14/00 ,  C12P9/00 ,  C12Q1/42 ,  C12Q1/485 ,  G01N33/533 ,  G01N33/542

    Abstract: Novel chemistries, methods and assays are described for the rapid detection and measurement of phosphorylation or de-phosphorylation of polypeptides, oligonucleotides or lipids based upon the use of phosphoryl, phosphoroamino or phosphorothioate specific hetero-bifunctional linkers combined with fluorescence polarization or fluorogenic detection. Homogeneous assay applications possible using these novel chemistries and methods include in vitro fluorescence polarization assays for the detection of general and isoform­ specific polypeptide, oligonucleotide and lipid kinase and phosphatase enzymes. Heterogeneous assay applications possible using the same novel chemistries and assaymethods enable development of in vitro and in vivo fluorogenic assays of general or specific kinase or phosphatase enzyme activities in cell lysates or serum. In all cases, these new chemistries, methods and assays enable simultaneous multi-kinase detection and profiling.

    Abstract translation: 描述了基于使用与荧光偏振或荧光检测结合的磷酰基，磷酰氨基或硫代磷酸酯特异性异双功能连接物快速检测和测量多肽，寡核苷酸或脂质的磷酸化或去磷酸化的新型化学，方法和测定法。 使用这些新颖化学和方法可能的均相测定应用包括用于检测一般和同种型特异性多肽，寡核苷酸和脂质激酶和磷酸酶的体外荧光偏振测定。 使用相同的新颖化学和测定方法可能的非均相测定应用使得能够开发在细胞裂解物或血清中的一般或特异性激酶或磷酸酶活性的体外和体内荧光测定。 在所有情况下，这些新的化学成分，方法和测定可以同时进行多激酶检测和分析。

    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES
    7.
    发明申请
    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES 审中-公开
    绿色绿色和橙色荧光标签及其用途

    公开(公告)号：WO2004027388A2

    公开(公告)日：2004-04-01

    申请号：PCT/US2003/030167

    申请日：2003-09-23

    Applicant: CHROMAGEN, INC. ,  BHATT, Ram ,  CONRAD, Michael, J. ,  BENCHEIKH, Azzouz ,  XIONG Yifeng

    Inventor： BHATT, Ram ,  CONRAD, Michael, J. ,  BENCHEIKH, Azzouz ,  XIONG Yifeng

    IPC: G01N

    CPC classification number: C07D207/46 ,  C07C309/50 ,  C07C309/51 ,  C07C311/29 ,  C07C331/20 ,  C07C2603/50 ,  C07D207/452 ,  G01N33/533 ,  Y10S436/80

    Abstract: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

    Abstract translation: 本发明提供了新颖的荧光化合物和共价附着化学物质，其有助于这些化合物用作低水平生物分子的超敏感和定量荧光检测的标签。 在优选的实施方案中，本发明的荧光标记是羟基芘三磺酸和二磺酸的新衍生物，其可用于目前使用放射​​性同位素，着色染料或其它荧光分子的任何测定中。 因此，例如，使用标记的抗体，蛋白质，寡核苷酸或脂质，包括荧光细胞分选，荧光显微术（包括暗视野显微镜），荧光偏振测定，配体，受体结合测定，受体激活测定和诊断测定法的任何测定都可以受益 使用本文公开的化合物。

    SCANNING SPECTROPHOTOMETER FOR HIGH THROUGHPUT FLUORESCENCE DETECTION
    8.
    发明申请
    SCANNING SPECTROPHOTOMETER FOR HIGH THROUGHPUT FLUORESCENCE DETECTION 审中-公开

    公开(公告)号：WO2002059584A3

    公开(公告)日：2002-08-01

    申请号：PCT/US2001/050136

    申请日：2001-12-31

    Applicant: CHROMAGEN, INC. ,  GOULD, Gene ,  CONRAD, Michael, J.

    Inventor： GOULD, Gene ,  CONRAD, Michael, J.

    IPC: G01N21/64

    Abstract: A fluorescence spectrophotometer system may be implemented in scanning fluorescence polarization detection applications. A wavelength and area scanning fluorescence spectrophotometer system may include a light source, an excitation double monochromator, an excitation/emission light transfer module, an emission double monochromator, a high speed timer-counter circuit board, a precision positioning apparatus for positioning a sample relative to the focal plane of the excitation light, and polarizing filters at the excitation side and the emission side. The system may be operative to analyze more than one fluorescent compound in the sample; additionally or alternatively, the system enables analysis of samples from selected ones of a plurality of samples.

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