公开(公告)号：WO2004101479A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/014043

申请日：2004-05-05

Applicant: E.I. DUPONT DE NEMOURS AND COMPANY ,  A. E. STALEY MANUFACTURING COMPANY ,  ADKESSON, Dennis, Michael ,  ALSOP, Albert, W. ,  AMES, Tyler, T ,  CHU, Luis, Alberto ,  DISNEY, James, M. ,  DRAVIS, Bryan, C. ,  FITZGIBBON, Patrick ,  GADDY, James, M. ,  GALLAGHER, F., Glenn ,  LEHNHARDT, William, F. ,  LIEVENSE, Jefferson, C. ,  LUYBEN, Michael, L. ,  SEAPAN, Mayis ,  TROTTER, Robert, E. ,  WENNDT, Gregory, M. ,  YU, Eugene, K.

Inventor： ADKESSON, Dennis, Michael ,  ALSOP, Albert, W. ,  AMES, Tyler, T ,  CHU, Luis, Alberto ,  DISNEY, James, M. ,  DRAVIS, Bryan, C. ,  FITZGIBBON, Patrick ,  GADDY, James, M. ,  GALLAGHER, F., Glenn ,  LEHNHARDT, William, F. ,  LIEVENSE, Jefferson, C. ,  LUYBEN, Michael, L. ,  SEAPAN, Mayis ,  TROTTER, Robert, E. ,  WENNDT, Gregory, M. ,  YU, Eugene, K.

IPC: C07C29/00

CPC classification number: B01D61/027 ,  B01D3/002 ,  B01D3/143 ,  B01D3/145 ,  B01D61/04 ,  B01D61/142 ,  B01D61/145 ,  B01D61/147 ,  B01D61/58 ,  B01D2311/04 ,  C07C29/76 ,  C07C29/80 ,  C12P7/18 ,  B01D2311/2623 ,  C07C31/205

Abstract: A process for purifying 1,3-propanediol from the fermentation broth of a cultured E. coli that has been bioengineered to synthesize 1,3-propanediol from sugar is provided. The basic process entails filtration, ion exchange and distillation of the fermentation broth product stream, preferably including chemical reduction of the product during the distillation procedure. Also provided are highly purified compositions of 1,3-propanediol.

Abstract translation: 本发明提供从已经生物工程化从糖中合成1,3-丙二醇的培养的大肠杆菌的发酵液中纯化1,3-丙二醇的方法。 基本过程需要发酵肉汤产品流的过滤，离子交换和蒸馏，优选在蒸馏过程中包括产物的化学还原。 还提供了高纯度的1,3-丙二醇组合物。

公开(公告)号：WO2004101479A3

公开(公告)日：2005-02-03

申请号：PCT/US2004014043

申请日：2004-05-05

Applicant: DU PONT ,  STALEY MFG CO A E ,  ADKESSON DENNIS MICHAEL ,  ALSOP ALBERT W ,  AMES TYLER T ,  CHU LUIS ALBERTO ,  DISNEY JAMES M ,  DRAVIS BRYAN C ,  FITZGIBBON PATRICK ,  GADDY JAMES M ,  GALLAGHER F GLENN ,  LEHNHARDT WILLIAM F ,  LIEVENSE JEFFERSON C ,  LUYBEN MICHAEL L ,  SEAPAN MAYIS ,  TROTTER ROBERT E ,  WENNDT GREGORY M ,  YU EUGENE K

Inventor： ADKESSON DENNIS MICHAEL ,  ALSOP ALBERT W ,  AMES TYLER T ,  CHU LUIS ALBERTO ,  DISNEY JAMES M ,  DRAVIS BRYAN C ,  FITZGIBBON PATRICK ,  GADDY JAMES M ,  GALLAGHER F GLENN ,  LEHNHARDT WILLIAM F ,  LIEVENSE JEFFERSON C ,  LUYBEN MICHAEL L ,  SEAPAN MAYIS ,  TROTTER ROBERT E ,  WENNDT GREGORY M ,  YU EUGENE K

IPC: B01D61/02 ,  B01D61/04 ,  B01D61/14 ,  B01D61/58 ,  C07C29/76 ,  C07C29/80 ,  C12P7/18 ,  C07C31/20

CPC classification number: B01D61/027 ,  B01D61/04 ,  B01D61/142 ,  B01D61/145 ,  B01D61/147 ,  B01D61/58 ,  B01D2311/04 ,  C07C29/76 ,  C07C29/80 ,  C12P7/18 ,  B01D2311/2623 ,  C07C31/205

Abstract: A process for purifying 1,3-propanediol from the fermentation broth of a cultured E. coli that has been bioengineered to synthesize 1,3-propanediol from sugar is provided. The basic process entails filtration, ion exchange and distillation of the fermentation broth product stream, preferably including chemical reduction of the product during the distillation procedure. Also provided are highly purified compositions of 1,3-propanediol.

Abstract translation: 本发明提供从已经生物工程化从糖中合成1,3-丙二醇的培养的大肠杆菌的发酵液中纯化1,3-丙二醇的方法。 基本过程需要发酵肉汤产品流的过滤，离子交换和蒸馏，优选在蒸馏过程中包括产物的化学还原。 还提供了高纯度的1,3-丙二醇组合物。