公开(公告)号：WO2004096744A3

公开(公告)日：2004-11-11

申请号：PCT/US2004/012246

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC. ,  LYSENKO, Zenon ,  MORRISON, Donald, L. ,  BABB, David, A. ,  BUNNING, Donald, L. ,  DERSTINE, Christopher, W. ,  GILCHRIST, James, H. ,  JOUETT, Ray, H. ,  KANEL, Jeffrey, S. ,  OLSON, Kurt, D. ,  PENG, Wei-Jun ,  PHILLIPS, Joe, D. ,  ROESCH, Brian, M. ,  SANDERS, Aaron, W. ,  SCHROCK, Alan, K. ,  THOMAS, P., J.

Inventor： LYSENKO, Zenon ,  MORRISON, Donald, L. ,  BABB, David, A. ,  BUNNING, Donald, L. ,  DERSTINE, Christopher, W. ,  GILCHRIST, James, H. ,  JOUETT, Ray, H. ,  KANEL, Jeffrey, S. ,  OLSON, Kurt, D. ,  PENG, Wei-Jun ,  PHILLIPS, Joe, D. ,  ROESCH, Brian, M. ,  SANDERS, Aaron, W. ,  SCHROCK, Alan, K. ,  THOMAS, P., J.

IPC: C07C67/347

Abstract: An aldehyde composition derived by hydroformylation of a transesterified seed oil and containing a mixture of formyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoformyl, greater than about 1 to less than about 65 percent diformyl, and greater than about 0.1 to less than about 10 percent triformyl-substituted fatty acids or fatty acid esters, and having a diformyl to triformyl weight ratio of greater than about 5/1; preferably, greater than about 3 to less than about 20 percent saturates; and preferably, greater than about 1 to less than about 20 percent unsaturates. An alcohol composition derived by hydrogenation of the aforementioned aldehyde composition, containing a mixture of hydroxymethyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoalcohol {mono(hydroxymethyl)}, greater than about 1 to less than about 65 percent diol {di(hydroxymethyl)}, greater than about 0.1 to less than about 10 percent triol, tri(hydroxmethyl)-substituted fatty acids or fatty acid esters; preferably greater than about 3 to less than about 35 percent saturates; and preferably, less than about 10 percent unsaturates. The alcohol composition can be converted into an oligomeric polyol for use in the manufacture of polyurethane slab stock flexible foams.

公开(公告)号：WO2004097028A2

公开(公告)日：2004-11-11

申请号：PCT/US2004/012447

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC. ,  SUBRAMANIAN, Venkiteswaran ,  CHRISTENSON, Christopher P. ,  CONBOY, Claire B. ,  LI, Kai ,  REDWINE, Oscar David ,  CHOPIN III, Lamy Jean ,  MILLER, Barbara A. ,  MORABITO, Paul L. ,  WINTERTON, Richard C. ,  ROSNER, Bettina M.

Inventor： SUBRAMANIAN, Venkiteswaran ,  CHRISTENSON, Christopher P. ,  CONBOY, Claire B. ,  LI, Kai ,  REDWINE, Oscar David ,  CHOPIN III, Lamy Jean ,  MILLER, Barbara A. ,  MORABITO, Paul L. ,  WINTERTON, Richard C. ,  ROSNER, Bettina M.

IPC: C12Q

CPC classification number: C12Q1/02 ,  G01N24/088 ,  G01N2500/00 ,  G01R33/465

Abstract: The present invention relates to methods and apparatus for the screening of biocatalysts. In particular, the present invention relates to high throughput nuclear magnetic resonance methods for the screening of biocatalysts to identify biocatalytic activities and to discover biocatalysts. The present invention provides improved high-throughput nuclear magnetic resonance analysis systems.

Abstract translation: 本发明涉及筛选生物催化剂的方法和装置。 特别地，本发明涉及用于筛选生物催化剂以识别生物催化活性和发现生物催化剂的高通量核磁共振方法。 本发明提供改进的高通量核磁共振分析系统。

公开(公告)号：WO2004096744A2

公开(公告)日：2004-11-11

申请号：PCT/US2004012246

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC ,  LYSENKO ZENON ,  MORRISON DONALD L ,  BABB DAVID A ,  BUNNING DONALD L ,  DERSTINE CHRISTOPHER W ,  GILCHRIST JAMES H ,  JOUETT RAY H ,  KANEL JEFFREY S ,  OLSON KURT D ,  PENG WEI-JUN ,  PHILLIPS JOE D ,  ROESCH BRIAN M ,  SANDERS AARON W ,  SCHROCK ALAN K ,  THOMAS P J

Inventor： LYSENKO ZENON ,  MORRISON DONALD L ,  BABB DAVID A ,  BUNNING DONALD L ,  DERSTINE CHRISTOPHER W ,  GILCHRIST JAMES H ,  JOUETT RAY H ,  KANEL JEFFREY S ,  OLSON KURT D ,  PENG WEI-JUN ,  PHILLIPS JOE D ,  ROESCH BRIAN M ,  SANDERS AARON W ,  SCHROCK ALAN K ,  THOMAS P J

IPC: C07C67/31 ,  C07C67/347 ,  C07C69/675 ,  C07C69/716 ,  C07C69/732 ,  C07C69/738 ,  C08G18/40 ,  C08G18/48 ,  C07C45/00

CPC classification number: C08G18/4891 ,  C07C67/31 ,  C07C67/347 ,  C07C69/675 ,  C07C69/716 ,  C07C69/732 ,  C07C69/738 ,  C08G18/4072 ,  C08G18/4804 ,  C08G18/4841 ,  C08G2101/0008 ,  C08G2101/005 ,  C08G2101/0083

Abstract: An aldehyde composition derived by hydroformylation of a transesterified seed oil and containing a mixture of formyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoformyl, greater than about 1 to less than about 65 percent diformyl, and greater than about 0.1 to less than about 10 percent triformyl-substituted fatty acids or fatty acid esters, and having a diformyl to triformyl weight ratio of greater than about 5/1; preferably, greater than about 3 to less than about 20 percent saturates; and preferably, greater than about 1 to less than about 20 percent unsaturates. An alcohol composition derived by hydrogenation of the aforementioned aldehyde composition, containing a mixture of hydroxymethyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoalcohol {mono(hydroxymethyl)}, greater than about 1 to less than about 65 percent diol {di(hydroxymethyl)}, greater than about 0.1 to less than about 10 percent triol, tri(hydroxmethyl)-substituted fatty acids or fatty acid esters; preferably greater than about 3 to less than about 35 percent saturates; and preferably, less than about 10 percent unsaturates. The alcohol composition can be converted into an oligomeric polyol for use in the manufacture of polyurethane slab stock flexible foams.

Abstract translation: 通过酯交换种子油的加氢甲酰化衍生的醛组合物，并含有具有以下重量组成的甲酰取代的脂肪酸或脂肪酸酯的混合物：大于约10至小于约95％的单甲基，大于约1至少 并且具有大于约65％的二甲酰基和大于约0.1至小于约10％的三甲酰基取代的脂肪酸或脂肪酸酯，并且具有大于约5/1的二甲酰基 - 三甲酰基重量比; 优选大于约3至小于约20％的饱和物; 并且优选大于约1至小于约20％的不饱和度。 通过上述醛组合物的氢化衍生的醇组合物，其含有羟甲基取代的脂肪酸或具有以下重量组成的脂肪酸酯的混合物：大于约10至小于约95％的一元醇（单（羟甲基）}， 大于约1至小于约65％的二醇{二（羟甲基）}，大于约0.1至小于约10％的三醇，三（羟甲基）取代的脂肪酸或脂肪酸酯; 优选大于约3至小于约35％的饱和物; 并且优选小于约10％的不饱和物。 醇组合物可以转化成用于制造聚氨酯板坯柔性泡沫的低聚多元醇。

公开(公告)号：WO2004097028A3

公开(公告)日：2009-03-26

申请号：PCT/US2004012447

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC ,  SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN III LAMY JEAN ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

Inventor： SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN III LAMY JEAN ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

IPC: C12Q1/00 ,  C12N9/78 ,  C12Q20060101 ,  C12Q1/02 ,  C12Q1/68 ,  G01N24/00 ,  G01R33/465 ,  G01V3/00 ,  G01V3/14

CPC classification number: C12Q1/02 ,  G01N24/088 ,  G01N2500/00 ,  G01R33/465

Abstract: The present invention relates to methods and apparatus for the screening of biocatalysts. In particular, the present invention relates to high throughput nuclear magnetic resonance methods for the screening of biocatalysts to identify biocatalytic activities and to discover biocatalysts. The present invention provides improved high-throughput nuclear magnetic resonance analysis systems.

Abstract translation: 本发明涉及筛选生物催化剂的方法和装置。 特别地，本发明涉及用于筛选生物催化剂以识别生物催化活性并发现生物催化剂的高通量核磁共振方法。 本发明提供改进的高通量核磁共振分析系统。

公开(公告)号：CA2610405C

公开(公告)日：2015-01-27

申请号：CA2610405

申请日：2006-06-06

Applicant: DOW GLOBAL TECHNOLGIES INC

Inventor： SCHNEIDER J CARRIE ,  ROSNER BETTINA

IPC: C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

Abstract: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention provides bacterial cells that have been genetically altered to inhibit the metabolism or degradation of mannitol, glucitol, or arabitol, or derivatives or analogues thereof. The present invention utilizes mannitol, arabitol, glucitol, or glycerol to induce expression of a target polypeptide from an inducible promoter, allowing for the use of an inexpensive and stable carbon source inducer in the fermentation processes for the production of recombinant peptides.

公开(公告)号：CA2545610C

公开(公告)日：2014-03-25

申请号：CA2545610

申请日：2004-11-19

Applicant: DOW GLOBAL TECHNOLGIES INC

Inventor： SCHNEIDER JANE C ,  CHEW LAWRENCE C ,  BADGLEY ANNE KATHRYN ,  RAMSEIER THOMAS MARTIN

IPC: C12N15/00 ,  C12N1/21 ,  C12N9/06 ,  C12N9/88 ,  C12N15/52 ,  C12N15/74 ,  C12N15/78 ,  C12P13/22 ,  C12P21/00 ,  C12P21/02

Abstract: The present invention provides an improved expression system for the production of recombinant polypeptides utilizing auxotrophic selectable markers. In addition, the present invention provides improved recombinant protein production in host cells through the improved regulation of expression. The host cells can be Pseudomonas fluorescens bacteria.

公开(公告)号：CA2523433A1

公开(公告)日：2004-11-11

申请号：CA2523433

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC

Inventor： BABB DAVID A ,  MORRISON DONALD L ,  LYSENKO ZENON ,  KANEL JEFFREY S ,  OLSON KURT D ,  BUNNING DONALD L ,  DERSTINE CHRISTOPHER W ,  JOUETT H RAY ,  GILCHRIST JAMES H ,  PENG WEI-JUN ,  ROESCH BRIAN M ,  SANDERS AARON W ,  PHILLIPS JOE D ,  THOMAS PULIKKOTTIL J ,  SCHROCK ALAN K

IPC: C07C67/31 ,  C07C67/347 ,  C07C69/675 ,  C07C69/716 ,  C07C69/732 ,  C07C69/738 ,  C08G18/40 ,  C08G18/48 ,  C11C3/00 ,  C11C3/12

Abstract: An aldehyde composition derived by hydroformylation of a transesterified see d oil and containing a mixture of formyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoformyl, greater than about 1 to less than abo ut 65 percent diformyl, and greater than about 0.1 to less than about 10 percen t triformyl-substituted fatty acids or fatty acid esters, and having a diformy l to triformyl weight ratio of greater than about 5/1; preferably, greater tha n about 3 to less than about 20 percent saturates; and preferably, greater tha n about 1 to less than about 20 percent unsaturates. An alcohol composition derived by hydrogenation of the aforementioned aldehyde composition, containing a mixture of hydroxymethyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoalcohol {mono(hydroxymethyl, greater than about 1 to less than about 65 percent diol {di(hydroxymethyl, greater than about 0.1 to less than about 10 percent triol, tri(hydroxmethyl)-substituted fatty acids or fatty acid esters; preferably greater than about 3 to less th an about 35 percent saturates; and preferably, less than about 10 percent unsaturates. The alcohol composition can be converted into an oligomeric polyol for use in the manufacture of polyurethane slab stock flexible foams.

公开(公告)号：CA2546157C

公开(公告)日：2014-07-22

申请号：CA2546157

申请日：2004-11-22

Applicant: DOW GLOBAL TECHNOLGIES INC

Inventor： RETALLACK DIANE M ,  SCHNEIDER JANE C ,  RAMSEIER THOMAS MARTIN

IPC: C07H21/04 ,  C07H7/00 ,  C07H19/00 ,  C07K14/21 ,  C07K14/61 ,  C07K16/00 ,  C07K16/16 ,  C12N1/21 ,  C12N15/10 ,  C12N15/62 ,  C12N15/63 ,  C12N15/64 ,  C12N15/72 ,  C12N15/78

Abstract: Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides.

公开(公告)号：UA86019C2

公开(公告)日：2009-03-25

申请号：UAA200510101

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC

Inventor： LYSENKO ZENON ,  BABB DAVID A ,  JOUETT RAY ,  PHILLIPS JOE D ,  SCHROCK ALAN K ,  THOMAS P J ,  KANEL JEFFREY S ,  MORRISON DONALD L ,  BUNNING DONALD L ,  DERSTINE CHRISTOPHER W ,  GILCHRIST JAMES H ,  SANDERS AARON W ,  OLSON KURT D ,  PENG WEI-JUN ,  ROESCH BRIAN M

IPC: C07C47/00 ,  C07C45/00 ,  C07C67/00 ,  C07C67/31 ,  C07C67/347 ,  C07C69/00 ,  C07C69/675 ,  C07C69/716 ,  C07C69/732 ,  C07C69/738 ,  C08G18/40 ,  C08G18/48