公开(公告)号：WO2004096988A8

公开(公告)日：2005-07-21

申请号：PCT/US2004012450

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLOGIES INC ,  SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN LAMY JEAN III ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

Inventor： SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN LAMY JEAN III ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

IPC: A01N65/00 ,  C12N20060101 ,  C12N1/00 ,  C12N1/20 ,  G01N33/542

CPC classification number: G01N33/542

Abstract: The present invention relates to methods and apparatus for the screening of biocatalysts. In particular, the present invention relates to high throughput nuclear magnetic resonance methods for the screening of biocatalysts to identify biocatalytic activities and to discover biocatalysts. The present invention further provides improved high-throughput nuclear magnetic resonance analysis systems.

Abstract translation: 本发明涉及筛选生物催化剂的方法和设备。 特别地，本发明涉及用于筛选生物催化剂以鉴定生物催化活性并发现生物催化剂的高通量核磁共振方法。 本发明还提供改进的高通量核磁共振分析系统。

公开(公告)号：WO2004097028A3

公开(公告)日：2009-03-26

申请号：PCT/US2004012447

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC ,  SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN III LAMY JEAN ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

Inventor： SUBRAMANIAN VENKITESWARAN ,  CHRISTENSON CHRISTOPHER P ,  CONBOY CLAIRE B ,  LI KAI ,  REDWINE OSCAR DAVID ,  CHOPIN III LAMY JEAN ,  MILLER BARBARA A ,  MORABITO PAUL L ,  WINTERTON RICHARD C ,  ROSNER BETTINA M

IPC: C12Q1/00 ,  C12N9/78 ,  C12Q20060101 ,  C12Q1/02 ,  C12Q1/68 ,  G01N24/00 ,  G01R33/465 ,  G01V3/00 ,  G01V3/14

CPC classification number: C12Q1/02 ,  G01N24/088 ,  G01N2500/00 ,  G01R33/465

Abstract: The present invention relates to methods and apparatus for the screening of biocatalysts. In particular, the present invention relates to high throughput nuclear magnetic resonance methods for the screening of biocatalysts to identify biocatalytic activities and to discover biocatalysts. The present invention provides improved high-throughput nuclear magnetic resonance analysis systems.

Abstract translation: 本发明涉及筛选生物催化剂的方法和装置。 特别地，本发明涉及用于筛选生物催化剂以识别生物催化活性并发现生物催化剂的高通量核磁共振方法。 本发明提供改进的高通量核磁共振分析系统。

公开(公告)号：WO2006127355A3

公开(公告)日：2007-03-29

申请号：PCT/US2006019079

申请日：2006-05-18

Applicant: DOW GLOBAL TECHNOLOGIES INC ,  MERCURE PETER KIP ,  JONES CHRISTOPHER M ,  WARREN MALCOLM W ,  BABINEC SUSAN J ,  BERNIUS MARK T ,  CASTILLO FLOR A ,  CRANLEY PAUL E ,  DANOWSKI KRISTINE L ,  FELIX MARK SB ,  FLETCHER ROBERT B ,  HALEY ROBERT PAUL ,  KALANTAR THOMAS H ,  MCDOUGALL CHRIS W ,  PRESSLER MICHELLE A ,  ROSNER BETTINA M ,  SIMON JAIME ,  STRAND DEIDRE A ,  SUN LARRY ,  WHITE DOUGLAS P

Inventor： MERCURE PETER KIP ,  JONES CHRISTOPHER M ,  WARREN MALCOLM W ,  BABINEC SUSAN J ,  BERNIUS MARK T ,  CASTILLO FLOR A ,  CRANLEY PAUL E ,  DANOWSKI KRISTINE L ,  FELIX MARK SB ,  FLETCHER ROBERT B ,  HALEY ROBERT PAUL ,  KALANTAR THOMAS H ,  MCDOUGALL CHRIS W ,  PRESSLER MICHELLE A ,  ROSNER BETTINA M ,  SIMON JAIME ,  STRAND DEIDRE A ,  SUN LARRY ,  WHITE DOUGLAS P

IPC: A61K9/48 ,  A61K9/20 ,  G06K19/077

CPC classification number: G06K19/04 ,  A01K11/007 ,  A61B5/4833 ,  A61J3/007 ,  A61J3/071 ,  A61J2200/30 ,  A61K9/0009 ,  A61K9/2072 ,  A61K9/4808 ,  G06K7/0008 ,  G06K7/10079 ,  G06K19/07327 ,  G06K19/07336 ,  G06K19/07345 ,  G06K19/07749 ,  H01Q1/2208 ,  H01Q1/273 ,  H01Q1/362 ,  H01Q7/00 ,  H01Q11/08

Abstract: A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device. In another embodiment, the instant invention is a device useful for oral drug delivery, consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) a first non-anti-collision RFID tag positioned in the capsule; (c) a second non-anti-collision RFID tag positioned in the capsule, so that if the RFID tags are interrogated by an RFID reader before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tags collide and so that after the dispersible material of the capsule has dispersed in the gastrointestinal system thereby allowing the first and second non-anti-collision tags to separate from each other, then the response of the RFID tags is sufficiently different from each other to determine that the capsule has dispersed in the gastrointestinal system.

Abstract translation: 用于口服药物递送装置的装置包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）定位在胶囊，药片或药丸中的RFID标签，RFID标签包括天线; （c）选自位于RFID标签的天线之内或之上的磁铁，铁磁物体，铁氧体物体和电磁屏蔽物体的物体，以改变RFID标签的天线特性，使得如果 在胶囊，片剂或药丸分散在胃肠系统中之前询问RFID标签，RFID标签的反应被充分改变或减弱，以确定胶囊，片剂或药片未分散在胃肠系统中，并且如果 在胶囊，片剂或药丸已经分散在胃肠系统中之后，RFID标签被询问，物体与RFID标签分离，使得RFID标签的反应充分可检测，以确定胶囊，片剂或药片已经分散在胃肠道 系统。 或者，可以使用开关来信号摄取设备，并且改变设备的响应。 在另一个实施方案中，本发明是用于口服药物递送的装置，其包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）位于所述胶囊中的第一非防撞RFID标签; （c）定位在胶囊中的第二个非防撞RFID标签，使得如果在胶囊，片剂或药片分散在胃肠系统中之前RFID读写器询问RFID标签，则RFID标签的响应与 使得在胶囊的可分散材料已经分散在胃肠系统中，从而允许第一和第二非抗冲突标签彼此分离，则RFID标签的响应彼此充分不同，以确定 胶囊已经分散在胃肠系统中。

公开(公告)号：WO2006127355A2

公开(公告)日：2006-11-30

申请号：PCT/US2006/019079

申请日：2006-05-18

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  MERCURE, Peter, Kip ,  JONES, Christopher, M. ,  WARREN, Malcolm, W. ,  BABINEC, Susan, J. ,  BERNIUS, Mark, T. ,  CASTILLO, Flor, A. ,  CRANLEY, Paul, E. ,  DANOWSKI, Kristine, L. ,  FELIX, Mark, SB ,  FLETCHER, Robert, B. ,  HALEY, Robert, Paul ,  KALANTAR, Thomas, H. ,  MCDOUGALL, Chris, W. ,  PRESSLER, Michelle, A. ,  ROSNER, Bettina, M. ,  SIMON, Jaime ,  STRAND, Deidre, A. ,  SUN, Larry ,  WHITE, Douglas, P.

Inventor： MERCURE, Peter, Kip ,  JONES, Christopher, M. ,  WARREN, Malcolm, W. ,  BABINEC, Susan, J. ,  BERNIUS, Mark, T. ,  CASTILLO, Flor, A. ,  CRANLEY, Paul, E. ,  DANOWSKI, Kristine, L. ,  FELIX, Mark, SB ,  FLETCHER, Robert, B. ,  HALEY, Robert, Paul ,  KALANTAR, Thomas, H. ,  MCDOUGALL, Chris, W. ,  PRESSLER, Michelle, A. ,  ROSNER, Bettina, M. ,  SIMON, Jaime ,  STRAND, Deidre, A. ,  SUN, Larry ,  WHITE, Douglas, P.

IPC: A61K9/48 ,  A61K9/20 ,  G06K19/077

CPC classification number: G06K19/04 ,  A01K11/007 ,  A61B5/4833 ,  A61J3/007 ,  A61J3/071 ,  A61J2200/30 ,  A61K9/0009 ,  A61K9/2072 ,  A61K9/4808 ,  G06K7/0008 ,  G06K7/10079 ,  G06K19/07327 ,  G06K19/07336 ,  G06K19/07345 ,  G06K19/07749 ,  H01Q1/2208 ,  H01Q1/273 ,  H01Q1/362 ,  H01Q7/00 ,  H01Q11/08

Abstract: A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device. In another embodiment, the instant invention is a device useful for oral drug delivery, consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) a first non-anti-collision RFID tag positioned in the capsule; (c) a second non-anti-collision RFID tag positioned in the capsule, so that if the RFID tags are interrogated by an RFID reader before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tags collide and so that after the dispersible material of the capsule has dispersed in the gastrointestinal system thereby allowing the first and second non-anti-collision tags to separate from each other, then the response of the RFID tags is sufficiently different from each other to determine that the capsule has dispersed in the gastrointestinal system.

Abstract translation: 用于口服药物递送装置的装置包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）定位在胶囊，药片或药丸中的RFID标签，RFID标签包括天线; （c）选自位于RFID标签的天线之内或之上的磁铁，铁磁体，铁氧体物体和电磁屏蔽物体的物体，以改变RFID标签的天线特性，使得如果 在胶囊，片剂或药丸分散在胃肠系统中之前询问RFID标签，RFID标签的反应被充分改变或减弱，以确定胶囊，片剂或药片未分散在胃肠系统中，并且如果 在胶囊，片剂或药丸已经分散在胃肠系统中之后，RFID标签被询问，物体与RFID标签分离，使得RFID标签的反应足够可检测，以确定胶囊，片剂或药片已经分散在胃肠道 系统。 或者，可以使用开关来信号摄取设备，并且改变设备的响应。 在另一个实施方案中，本发明是用于口服药物递送的装置，其包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）位于所述胶囊中的第一非防撞RFID标签; （c）定位在胶囊中的第二个非防撞RFID标签，使得如果在胶囊，片剂或药丸分散在胃肠系统中之前RFID读写器询问RFID标签，则RFID标签的响应与 使得在胶囊的可分散材料已经分散在胃肠系统中，从而允许第一和第二非抗冲突标签彼此分离，则RFID标签的响应彼此充分地不同，以确定 胶囊已经分散在胃肠系统中。

公开(公告)号：WO2004097028A2

公开(公告)日：2004-11-11

申请号：PCT/US2004/012447

申请日：2004-04-22

Applicant: DOW GLOBAL TECHNOLGIES INC. ,  SUBRAMANIAN, Venkiteswaran ,  CHRISTENSON, Christopher P. ,  CONBOY, Claire B. ,  LI, Kai ,  REDWINE, Oscar David ,  CHOPIN III, Lamy Jean ,  MILLER, Barbara A. ,  MORABITO, Paul L. ,  WINTERTON, Richard C. ,  ROSNER, Bettina M.

Inventor： SUBRAMANIAN, Venkiteswaran ,  CHRISTENSON, Christopher P. ,  CONBOY, Claire B. ,  LI, Kai ,  REDWINE, Oscar David ,  CHOPIN III, Lamy Jean ,  MILLER, Barbara A. ,  MORABITO, Paul L. ,  WINTERTON, Richard C. ,  ROSNER, Bettina M.

IPC: C12Q

CPC classification number: C12Q1/02 ,  G01N24/088 ,  G01N2500/00 ,  G01R33/465

Abstract: The present invention relates to methods and apparatus for the screening of biocatalysts. In particular, the present invention relates to high throughput nuclear magnetic resonance methods for the screening of biocatalysts to identify biocatalytic activities and to discover biocatalysts. The present invention provides improved high-throughput nuclear magnetic resonance analysis systems.

Abstract translation: 本发明涉及筛选生物催化剂的方法和装置。 特别地，本发明涉及用于筛选生物催化剂以识别生物催化活性和发现生物催化剂的高通量核磁共振方法。 本发明提供改进的高通量核磁共振分析系统。

公开(公告)号：WO03039483A2

公开(公告)日：2003-05-15

申请号：PCT/US0236028

申请日：2002-11-08

Applicant: DOW GLOBAL TECHNOLOGIES INC ,  CRANLEY PAUL E ,  ALLEN JEFFREY R ,  DANOWSKI KRISTINE L ,  MCINTYRE JAMES A ,  MILLER THEODORE E JR ,  ROSNER BETTINA M ,  STRICKLAND ALAN D ,  SUBRAMANIAN VENKITESWARAN ,  SUN LARRY

Inventor： CRANLEY PAUL E ,  ALLEN JEFFREY R ,  DANOWSKI KRISTINE L ,  MCINTYRE JAMES A ,  MILLER THEODORE E JR ,  ROSNER BETTINA M ,  STRICKLAND ALAN D ,  SUBRAMANIAN VENKITESWARAN ,  SUN LARRY

IPC: A61B5/00 ,  A61B5/08 ,  A61B10/00 ,  C12P7/04 ,  C12P7/28 ,  A61K

CPC classification number: A61B5/411 ,  A61B5/0002 ,  A61B5/083 ,  A61B10/00 ,  A61B2010/0009 ,  C12P7/04 ,  C12P7/28

Abstract: Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.

Abstract translation: 描述了丙酮特有的酶系统和使用这些酶系统检测生物或环境样品中的丙酮的方法。 公开了含有这些酶系统的生物传感器，其中可以通过将电化学，光度或其它检测手段与一种或多种丙酮特异性酶反应或途径连接来实现丙酮的检测。 使用这种丙酮特异性生物传感器的方法包括体重减轻，疾病检测和治疗剂的生物利用度监测的受试者管理。

公开(公告)号：WO2006017576A3

公开(公告)日：2006-06-01

申请号：PCT/US2005027565

申请日：2005-08-02

Applicant: UNIV LELAND STANFORD JUNIOR ,  SPORMANN ALFRED M ,  MULLER JOCHEN A ,  ROSNER BETTINA M ,  VON ABENDROTH GREGORY ,  MESHULAM-SIMON GALIT ,  MCCARTY PERRY L

Inventor： SPORMANN ALFRED M ,  MULLER JOCHEN A ,  ROSNER BETTINA M ,  VON ABENDROTH GREGORY ,  MESHULAM-SIMON GALIT ,  MCCARTY PERRY L

IPC: C12N1/12 ,  A01N63/00

CPC classification number: C12N1/30 ,  B09C1/002 ,  C12N9/0004

Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.

Abstract translation: 提供了涉及氯化乙烯的生物修复，特别是类Dehalococcoides生物体对氯乙烯的生物修复的组合物和方法。 一种分离的细菌菌株Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤作用的酶的基因序列; 评估环境部位内源性有机体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。

公开(公告)号：WO2003039483A3

公开(公告)日：2003-05-15

申请号：PCT/US2002/036028

申请日：2002-11-08

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  CRANLEY, Paul, E. ,  ALLEN, Jeffrey, R. ,  DANOWSKI, Kristine, L. ,  MCINTYRE, James, A. ,  MILLER, Theodore, E., Jr. ,  ROSNER, Bettina, M. ,  STRICKLAND, Alan, D. ,  SUBRAMANIAN, Venkiteswaran ,  SUN, Larry

Inventor： CRANLEY, Paul, E. ,  ALLEN, Jeffrey, R. ,  DANOWSKI, Kristine, L. ,  MCINTYRE, James, A. ,  MILLER, Theodore, E., Jr. ,  ROSNER, Bettina, M. ,  STRICKLAND, Alan, D. ,  SUBRAMANIAN, Venkiteswaran ,  SUN, Larry

IPC: C12N9/02

Abstract: Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.

公开(公告)号：WO2003039367A1

公开(公告)日：2003-05-15

申请号：PCT/US2002/036027

申请日：2002-11-08

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  ALLEN, Jeffrey, R. ,  CRANLEY, Paul, E ,  DANOWSKI, Kristine, L. ,  MCINTYRE, James, A. ,  SHICK, Reed, A. ,  SUN, Larry ,  ROSNER, Bettina, M.

Inventor： ALLEN, Jeffrey, R. ,  CRANLEY, Paul, E ,  DANOWSKI, Kristine, L. ,  MCINTYRE, James, A. ,  SHICK, Reed, A. ,  SUN, Larry ,  ROSNER, Bettina, M.

IPC: A61B5/08

CPC classification number: A61B5/411 ,  A61B5/0002 ,  A61B5/083 ,  A61B10/00 ,  A61B2010/0009 ,  C12P7/04 ,  C12P7/28

Abstract: The subject invention provides a hand-held medical apparatus (10) for detecting a predetermined component of user breath and producing a breath-component signal over a measurement time. Such breath-component signal may be correlated to a user fat metabolism indicator.

Abstract translation: 本发明提供一种用于检测用户呼吸的预定成分并在测量时间产生呼吸分量信号的手持式医疗装置10。 这样的呼吸分量信号可以与用户脂肪代谢指示符相关。

公开(公告)号：WO2006017576A2

公开(公告)日：2006-02-16

申请号：PCT/US2005/027565

申请日：2005-08-02

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  SPORMANN, Alfred M. ,  MULLER, Jochen A. ,  ROSNER, Bettina M. ,  VON ABENDROTH, Gregory ,  MESHULAM-SIMON, Galit ,  MCCARTY, Perry L.

Inventor： SPORMANN, Alfred M. ,  MULLER, Jochen A. ,  ROSNER, Bettina M. ,  VON ABENDROTH, Gregory ,  MESHULAM-SIMON, Galit ,  MCCARTY, Perry L.

IPC: C12N1/21

CPC classification number: C12N1/30 ,  B09C1/002 ,  C12N9/0004

Abstract: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides -like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of assessing the capability of endogenous organisms at an environmental site to metabolize vinyl chloride; and a method of using the strains of the invention for bioremediation.

Abstract translation: 提供了组合物和方法，其涉及氯代乙炔的生物修复，特别是由脱卤胆酸类生物体对氯乙烯的生物修复。 分离菌株，Dehalococcoides sp。 提供代谢氯乙烯的菌株VS; 负责氯乙烯脱卤的酶的基因序列; 评估环境部位内源生物体代谢氯乙烯能力的方法; 以及使用本发明的菌株进行生物修复的方法。