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    DEVICE-ASSISTED EYE IMAGING AND/OR MEASUREMENT
    3.
    发明申请
    DEVICE-ASSISTED EYE IMAGING AND/OR MEASUREMENT 审中-公开

    公开(公告)号：WO2022133177A1

    公开(公告)日：2022-06-23

    申请号：PCT/US2021/063967

    申请日：2021-12-17

    Applicant: TESSERACT HEALTH, INC. ,  RALSTON, Tyler, S. ,  ROTHBERG, Jonathan, M. ,  GLENN, Paul, E. ,  MEYERS, Mark, M. ,  COUMANS, Jacob ,  GLENN, John

    Inventor： ARIENZO, Maurizio ,  DEHOOG, Edward, A.

    IPC: A61B3/14 ,  A61B3/00 ,  A61B3/113 ,  A61B3/12 ,  A61B3/18

    Abstract: Aspects of the present disclosure provide improved techniques to assist imaging and/or measuring a subject's eye that are suitable for use in an imaging and/or measuring apparatus operated by the subject, even in the absence of a clinician or technician, thereby improving access to medical grade imaging and/or measurement. Some aspects relate to techniques for receiving user input and capturing a medical grade image and/or measurement of a subject's eye responsive to receiving the user input. Some aspects relate to techniques for providing visual feedback to a user of an imaging and/or measuring apparatus indicating a location of a subject's eye in a field of view of the imaging and/or measuring apparatus. Some aspects relate to techniques for selectively illuminating a first portion of a subject's eye with illumination light and capturing an image of the first portion of the subject's eye.

    MODIFIED PROTEINS AND METHODS OF MAKING AND USING SAME
    6.
    发明申请
    MODIFIED PROTEINS AND METHODS OF MAKING AND USING SAME 审中-公开
    修饰的蛋白质及其制备和使用方法

    公开(公告)号：WO2011106634A3

    公开(公告)日：2012-05-03

    申请号：PCT/US2011026228

    申请日：2011-02-25

    Applicant: LIFE TECHNOLOGIES CORP ,  DAVIDSON JOHN F ,  HINZ WOLFGANG ,  ROTHBERG JONATHAN ,  WHITAKER RICHARD

    Inventor： DAVIDSON JOHN F ,  HINZ WOLFGANG ,  ROTHBERG JONATHAN ,  WHITAKER RICHARD

    IPC: C12Q1/68 ,  C12N9/12 ,  C12Q1/48

    CPC classification number: C12N9/1252

    Abstract: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.

    Abstract translation: 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的修饰的核酸结合蛋白的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰的修饰蛋白以实现期望的pKa值的方法。 此外，本发明提供了在离子生成反应中使用这些修饰蛋白的方法，如基于离子的核酸测序反应。

    MODIFIED PROTEINS AND METHODS OF MAKING AND USING SAME
    7.
    发明申请
    MODIFIED PROTEINS AND METHODS OF MAKING AND USING SAME 审中-公开
    修饰的蛋白质及其制备和使用方法

    公开(公告)号：WO2011106634A2

    公开(公告)日：2011-09-01

    申请号：PCT/US2011/026228

    申请日：2011-02-25

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  DAVIDSON, John, F. ,  HINZ, Wolfgang ,  ROTHBERG, Jonathan ,  WHITAKER, Richard

    Inventor： DAVIDSON, John, F. ,  HINZ, Wolfgang ,  ROTHBERG, Jonathan ,  WHITAKER, Richard

    IPC: C12Q1/68 ,  C12Q1/48 ,  C12N9/12

    CPC classification number: C12N9/1252

    Abstract: Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.

    Abstract translation: 提供了包含修饰的蛋白质，特别是具有改变的缓冲性质的修饰的核酸结合蛋白的方法，组合物，系统，装置和试剂盒。 例如，在一些实施方案中，描述了形成包含一个或多个氨基酸修饰的修饰蛋白以实现期望的pKa值的方法。 此外，本发明提供了在离子生成反应中使用这些修饰蛋白的方法，如基于离子的核酸测序反应。

    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    8.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：WO2010047804A1

    公开(公告)日：2010-04-29

    申请号：PCT/US2009005745

    申请日：2009-10-22

    Applicant: ION TORRENT SYSTEMS INC ,  ROTHBERG JONATHAN M ,  SCHULTZ JONATHAN C ,  JOHNSON KIM L ,  REARICK TODD M ,  MILGREM MARK JAMES ,  MARRAN DAVID ,  BUSTILLO JAMES M

    Inventor： ROTHBERG JONATHAN M ,  SCHULTZ JONATHAN C ,  JOHNSON KIM L ,  REARICK TODD M ,  MILGREM MARK JAMES ,  MARRAN DAVID ,  BUSTILLO JAMES M

    IPC: G01N27/416 ,  C12M1/34

    CPC classification number: G01N27/4145

    Abstract: The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 µm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof. Apparatus and chips of the invention may be adapted for large scale pH-based DNA sequencing and other bioscience and biomedical applications.

    Abstract translation: 本发明涉及包括大规模化学场效应晶体管阵列的装置和芯片，其包括能够保留来自样品流体的化学或生物样品用于分析的样品保持区阵列。 在一个方面，这种晶体管阵列具有10μm或更小的间距，并且每个采样保持区域位于至少一个化学场效应晶体管上，该晶体管被配置为产生与化学或生物样品的特性相关的至少一个输出信号 在这样的样品保留区域中。 在一个实施方案中，所述化学或生物样品的特征是带电物质的浓度，并且其中每个所述化学场效应晶体管是离子敏感场效应晶体管，其具有在其表面上具有介电层的浮置栅极， 电介质层与所述样品流体接触并且能够与所述样品流体中的带电物质的浓度成比例地积累电荷。 在一个实施方案中，这种带电物质是氢离子，使得传感器测量样品流体在其样品保持区域中或其附近的pH值的变化。 本发明的装置和芯片可适用于大规模的基于pH的DNA测序和其他生物科学和生物医学应用。

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