公开(公告)号：WO02070660A2

公开(公告)日：2002-09-12

申请号：PCT/US0206485

申请日：2002-03-04

Applicant: CURAGEN CORP ,  COR THERAPEUTICS ,  KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

Inventor： KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

IPC: A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码相同的多肽和核酸。 还揭示了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO02070707A2

公开(公告)日：2002-09-12

申请号：PCT/US0149168

申请日：2001-12-18

Applicant: CURAGEN CORP ,  COR THERAPEUTICS INC ,  PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

Inventor： PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

IPC: A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO0216599A2

公开(公告)日：2002-02-28

申请号：PCT/US0126510

申请日：2001-08-27

Applicant: CURAGEN CORP ,  COR THERAPEUTICS INC ,  BURGESS CATHERINE E ,  CONLEY PAMELA B ,  GROSSE WILLIAM M ,  HART MATTHEW ,  KEKUDA RAMESH ,  SHIMKETS RICHARD A ,  SPYTEK KIMBERLY A ,  SZEKERES EDWARD S JR ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  YANG RUEY BIN

Inventor： BURGESS CATHERINE E ,  CONLEY PAMELA B ,  GROSSE WILLIAM M ,  HART MATTHEW ,  KEKUDA RAMESH ,  SHIMKETS RICHARD A ,  SPYTEK KIMBERLY A ,  SZEKERES EDWARD S JR ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  YANG RUEY-BIN

IPC: A61K38/00 ,  C07K14/47 ,  C12N15/00

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任何一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2004063340A3

公开(公告)日：2005-07-14

申请号：PCT/US2004000393

申请日：2004-01-13

Applicant: MILLENNIUM PHARM INC ,  STAGLIANO NANCY E ,  HEALY AILEEN ,  ACTON SUSAN L ,  GALVIN KATHERINE M ,  DONOGHUE MARY A ,  ROGRIGUE-WAY AMELIE ,  TOMLINSON JAMES E

Inventor： STAGLIANO NANCY E ,  HEALY AILEEN ,  ACTON SUSAN L ,  GALVIN KATHERINE M ,  DONOGHUE MARY A ,  ROGRIGUE-WAY AMELIE ,  TOMLINSON JAMES E

IPC: C07K14/47 ,  G01N33/53 ,  A61K38/00 ,  C07K14/00

CPC classification number: C07K14/47

Abstract: The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or non­cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

Abstract translation: 本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。 具体地说，本发明鉴定了1722,1028,8059917,85553,1063,53235,26668,17794,2210,6169,1010,21061,17662,1468,12282,65050,9035,1820,236522,7301,6005的标准差， 8925,8701,33533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10677,261,44570,41922,2552,2417,19319,4399， 8921,8993,905,232345,996,1920,17318,1510,14180,26205,554,16408,42028,112091,13886,13942,1673,5496和2419中的基因，相对于它们在正常的表达，心血管疾病状态， 或非心血管疾病状态，和/或响应与心血管疾病相关的操作。 本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能调节心血管疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

公开(公告)号：CA273167A

公开(公告)日：1927-08-16

申请号：CA273167D

Applicant: TOMLINSON JAMES E

Inventor： TOMLINSON JAMES E