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公开(公告)号：WO1996037432A1
公开(公告)日：1996-11-28
申请号：PCT/CA1995000316
申请日：1995-05-26
Applicant: VASOGEN INC. , DAVIDSON, William, E.
Inventor： VASOGEN INC.
IPC: C01B13/11
CPC classification number: C01B13/115 , C01B13/11 , C01B2201/12 , C01B2201/22 , C01B2201/90
Abstract: An apparatus for generating ozone from an oxygen supply. The apparatus comprising grids mounted in an enclosure and a high voltage circuit coupled to the grids for generating an electric field. The high voltage circuit receives AC power and includes a control circuit for producing a linearly controlled high voltage output from the AC feed for energizing the grids. The apparatus also includes an in-line sensor for determining the level of ozone being produced without affecting the ozone concentration. The high voltage circuit is also suitable for other applications where a precisely controlled high voltage output signal is needed.
Abstract translation: 一种用于从氧气供应产生臭氧的装置。 该装置包括安装在外壳中的栅格和耦合到栅极的用于产生电场的高压电路。 高电压电路接收交流电力，并且包括用于从AC馈电产生线性控制的高电压输出以控制电网的控制电路。 该装置还包括用于确定所产生的臭氧水平而不影响臭氧浓度的在线传感器。 高压电路也适用于需要精确控制的高压输出信号的其他应用。
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公开(公告)号：WO1996034613A1
公开(公告)日：1996-11-07
申请号：PCT/CA1996000282
申请日：1996-05-03
Applicant: VASOGEN INC. , BOLTON, Anthony, Ernest , COOKE, Ernest, Davidson
Inventor： VASOGEN INC.
IPC: A61K35/14
Abstract: Vasospastic disorders such as Raynaud's phenomenon are treated by administering to the patient an aliquot of autologous blood which has been subjected simultaneously to heat, ultraviolet irradiation and oxidative environment so as to render the blood aliquot capable of generating in the patient's bloodstream after administration a population of stimulated leukocytes having upregulated expression of CD25 cell surface markers, along with an enhancement of endothelial function in the patient.
Abstract translation: 诸如雷诺现象的血管痉挛性疾病通过向患者施用等量的自体血液来治疗，所述自体血液已经同时进行加热，紫外线照射和氧化环境，以便在给予患者的血液中使血液等分量能够在患者的血液中产生 刺激的白细胞具有上调CD25细胞表面标志物的表达，以及患者内皮功能的增强。
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3.发明申请
公开(公告)号：WO0067764A3
公开(公告)日：2001-02-08
申请号：PCT/CA0000566
申请日：2000-05-08
Applicant: VASOGEN INC , BOLTON ANTHONY E
Inventor： BOLTON ANTHONY E
CPC classification number: A61M1/3681 , A61K35/14 , A61K41/0014 , A61M1/3683 , A61M1/3687 , A61M1/369 , A61M2205/053
Abstract: An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to the subject from two to four aliquots of modified mammalian blood, with the administration of any pair of consecutive treatments either being on consecutive days or being separated by a rest period of 1 to 21 days. The treatment is useful for treating or preventing a wide range of pathological conditions in which modified mammalian blood is effective, including preconditioning a mammalian subject to better withstand the adverse effects of ischemic stress, atherosclerosis and rheumatoid arthritis.
Abstract translation: 一种用于治疗或预防哺乳动物受试者的病理状况的改进方法，其中向受试者施用修饰的哺乳动物血液。 该方法包括向受试者施用二至四等份的修饰的哺乳动物血液，施用任何一对连续的处理或连续数天或分开1至21天的休息期。 该治疗可用于治疗或预防修饰的哺乳动物血液有效的广泛病理状况，包括预处理哺乳动物受试者以更好地抵御缺血性应激，动脉粥样硬化和类风湿性关节炎的不良作用。
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公开(公告)号：WO0006703A3
公开(公告)日：2000-05-04
申请号：PCT/CA9900706
申请日：1999-07-30
Applicant: VASOGEN INC
Inventor： SPANER DAVID ELLIOTT
IPC: C12N5/02 , A61K35/17 , A61K35/28 , A61P35/02 , A61P43/00 , C12N5/0783 , C12N5/08 , A61K35/14 , A61P37/06
CPC classification number: C12N5/0636 , A61K35/17 , A61K35/28 , A61K41/0019 , C12N2500/02 , C12N2500/05 , Y10S424/81 , A61K2300/00
Abstract: The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, extracorporeally, to oxidative stress, in appropriate dosage amounts, such as bubbling a gaseous mixture of ozone and oxygen through a suspension of the T-cells. The process may also include irradiation of the cells with UV light, simultaneously with the application of the oxidative stress. The oxidative stress induces reduced inflammatory cytokine production and a reduced proliferative response in the T-cells.
Abstract translation: 在接受细胞移植治疗骨髓介导的疾病的哺乳动物患者中的移植物抗宿主病的发展通过至少将同种异体细胞移植组合物的T细胞体外氧化应激进行预防或缓解 合适的剂量，例如通过T细胞的悬浮液鼓泡臭氧和氧气的气体混合物。 该方法还可以包括用UV光照射细胞，同时施加氧化应激。 氧化应激诱导炎症细胞因子产生减少，T细胞增殖反应降低。
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5.发明申请APPARATUS AND METHOD FOR CALIBRATING AND VERIFYING THE GENERATION AND DELIVERY OF OZONE 审中-公开用于校准和验证臭氧发生和输送的装置和方法
公开(公告)号：WO1997049636A1
公开(公告)日：1997-12-31
申请号：PCT/CA1997000445
申请日：1997-06-24
Applicant: VASOGEN INC. , DAVIDSON, William, E.
Inventor： VASOGEN INC.
IPC: C01B13/11
CPC classification number: C01B13/11 , C01B13/115 , C01B2201/12 , C01B2201/22 , C01B2201/90
Abstract: An apparatus and method for calibrating the generation and verifying the delivery of ozone from an ozone generator. The apparatus comprises an in-line ozone sensor and a UV absorption type ozone sensor. The in-line ozone sensor is coupled to the ozone generator and determines the ozone concentration from the discharges during production of the ozone. The UV absorption sensor is coupled, through a two-way valve, between the outlet of the ozone generator and the inlet to an exposure vessel. The UV absorption sensor provides ozone concentration readings to verify and calibrate the operation of the ozone sensor and the in-line sensor. Once calibrated, the two-way valve is actuated to bypass the UV absorption sensor and feed the ozone directly to the exposure vessel.
Abstract translation: 一种用于校准来自臭氧发生器的臭氧的产生和验证的装置和方法。 该装置包括在线臭氧传感器和UV吸收型臭氧传感器。 在线臭氧传感器耦合到臭氧发生器，并且在臭氧生产期间确定来自排放物的臭氧浓度。 UV吸收传感器通过二通阀连接在臭氧发生器的出口和暴露容器的入口之间。 紫外线吸收传感器提供臭氧浓度读数，以验证和校准臭氧传感器和串联传感器的操作。 一旦校准，双向阀被致动以绕过UV吸收传感器并将臭氧直接供给到曝光容器。
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Patent Agency Ranking
公开(公告)号：WO1998007436A1
公开(公告)日：1998-02-26
申请号：PCT/CA1997000564
申请日：1997-08-11
Applicant: VASOGEN INC.
Inventor： VASOGEN INC. , BOLTON, Anthony, E.
IPC: A61K35/14
CPC classification number: A61M1/3681 , A61K33/40 , A61K35/14 , A61K41/0019 , A61M1/32 , A61M1/3683 , A61M2202/0216 , A61M2202/0275 , A61M2205/053 , Y10S424/81
Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia , leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
Abstract translation: 提供了一种自身免疫性疫苗，用于给予人类患者以减轻自身免疫疾病如类风湿性关节炎的症状。 疫苗包含患者血液的等分试样，其中尤其含有具有上调表达各种细胞表面标志物的白细胞和含有减少量某些应激蛋白的淋巴细胞。 它是通过将血液等分试样经受某些压力源，即氧化剂，紫外线辐射和升高的温度而产生的。
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公开(公告)号：AU760465B2
公开(公告)日：2003-05-15
申请号：AU6252100
申请日：2000-10-06
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY ERNEST , COOKE ERNEST DAVIDSON
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公开(公告)号：DK0680346T3
公开(公告)日：2002-10-28
申请号：DK93904180
申请日：1993-02-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: A method of increasing the nitric oxide concentration in the blood which comprises contacting blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation. Blood prepared by the method of the invention is used for treating a variety of conditions benefited by increased blood levels of nitric oxide.
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公开(公告)号：AT219953T
公开(公告)日：2002-07-15
申请号：AT93904180
申请日：1993-02-08
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: A method of increasing the nitric oxide concentration in the blood which comprises contacting blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation. Blood prepared by the method of the invention is used for treating a variety of conditions benefited by increased blood levels of nitric oxide.
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公开(公告)号：AU724265B2
公开(公告)日：2000-09-14
申请号：AU3844297
申请日：1997-08-11
Applicant: VASOGEN INC
Inventor： BOLTON ANTHONY E
Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.
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