公开(公告)号：KR1020030012641A

公开(公告)日：2003-02-12

申请号：KR1020010046774

申请日：2001-08-02

Applicant: (주)씨앤팜

Inventor： 최진호 ,  곽서영 ,  손유환

IPC: C07F19/00

CPC classification number: A61K8/4973 ,  A23K20/174 ,  A23L33/15 ,  A61K8/19

Abstract: PURPOSE: Provided are vitamin-inorganic hybrid which has excellent stability to heat, light and oxygen and excellent dispersibility, and sustainedly releases vitamin to maintain efficacies of vitamin for a ling time, and a preparation thereof. CONSTITUTION: The vitamin-inorganic hybrid complex is characterized by inserting vitamin or its derivative between layers of layered double metal hydroxide as an inorganic carrier by ion exchange reaction. It is represented by the formula:(M¬2+ 1-x N¬3+ x (OH)2)(A¬n-)x/n yH2O.

Abstract translation: 目的：提供维生素 - 无机杂化物，其对热，光和氧具有优异的稳定性和优异的分散性，并持续释放维生素以维持维生素的有效时间及其制备。 构成：维生素 - 无机杂化复合物的特征在于通过离子交换反应将维生素或其衍生物插入作为无机载体的层状双金属氢氧化物层之间。 它由下式表示：（M + 2 + 1-x N-3 + x（OH）2）（A n-）x / n yH 2 O。

公开(公告)号：KR100359716B1

公开(公告)日：2003-04-21

申请号：KR1019980037497

申请日：1998-09-11

Applicant: (주)씨앤팜

Inventor： 최진호 ,  곽서영 ,  박종상

IPC: C07H19/00

CPC classification number: C12N15/1003

Abstract: Disclosed is a bio-inorganic hybrid composite for retaining and carrying bio-materials with stability and reversible dissociativity, represented by the following chemical Formula I and a method for preparing the same. The bio-inorganic hybrid composite is prepared by (a) coprecipitating with an alkaline material an aqueous solution comprising a bivalent metal (M(II)) and a trivalent metal (N(III)) at a molar ratio satisfying the condition of 1/5 ≤b/(a+b)≤ 1/2 wherein a and b represent a mole number of M and N, respectively, to form a stable layered double hydroxide in which anions are intercalated and (b) subjecting the intercalated anions to ion exchange reaction with a bio-material to compensate for layer charges of the layered double hydroxide. This composite is harmless to the body and artificially controls the appropriate expression of the bio-material retained therein. ÄM  1-xN  x(OH)2Ü ÄABIO  Üx/n.yH2O wherein, M is a bivalent metal cation; N is a trivalent metal cation; ABIO is an anionic bio-material with n charges; x is a rational number between 0 to 1; and y is a positive number.

Abstract translation: 公开了一种用于保持和携带具有稳定性和可逆解离性的生物材料的生物 - 无机混合复合材料，由以下化学式I表示，及其制备方法。 该生物 - 无机杂化复合材料通过（a）以满足条件1/2的摩尔比与碱性材料共沉淀包含二价金属（M（II））和三价金属（N（III））的水溶液来制备。 5＆amp; le; b /（a + b）＆amp; le; 1/2，其中a和b分别代表M和N的摩尔数，以分别形成其中插入有阴离子的稳定的层状双氢氧化物，和（b）使插入的阴离子与生物材料发生离子交换反应以补偿 层状双氢氧化物的层电荷。 这种复合材料对身体无害并且人为控制其中保留的生物材料的适当表现。 ＆AUML; M＆LT; 2+;＆安培; hairsp; 1-XN＆LT; 3+;＆安培; hairsp; X（OH）2＆Uuml; ＆Auml; ABIO＆amp; hairsp;＆lt; n＆gt; x / n.yH 2 O其中，M是二价金属阳离子; N是三价金属阳离子; ABIO是一种具有n电荷的阴离子生物材料; x是0到1之间的有理数; y是一个正数。

公开(公告)号：KR100443892B1

公开(公告)日：2004-08-09

申请号：KR1020010046774

申请日：2001-08-02

Applicant: (주)씨앤팜

Inventor： 최진호 ,  곽서영 ,  손유환

IPC: C07F19/00

Abstract: PURPOSE: Provided are vitamin-inorganic hybrid which has excellent stability to heat, light and oxygen and excellent dispersibility, and sustainedly releases vitamin to maintain efficacies of vitamin for a ling time, and a preparation thereof. CONSTITUTION: The vitamin-inorganic hybrid complex is characterized by inserting vitamin or its derivative between layers of layered double metal hydroxide as an inorganic carrier by ion exchange reaction. It is represented by the formula:(M¬2+ 1-x N¬3+ x (OH)2)(A¬n-)x/n yH2O.

Abstract translation: 用途：提供一种维生素 - 无机杂化剂，其对热，光和氧具有优异的稳定性和优异的分散性，并持续释放维生素以维持维生素的疗效，并提供一种制剂。 组成：维生素 - 无机杂化复合物的特征在于通过离子交换反应将维生素或其衍生物插入层状双金属氢氧化物层之间作为无机载体。 它由下式表示：（M 2+ 2+ 1-x N 3+ x（OH）2）（A n - n - ）x / n y H 2 O.

公开(公告)号：KR1020000019408A

公开(公告)日：2000-04-06

申请号：KR1019980037497

申请日：1998-09-11

Applicant: (주)씨앤팜

Inventor： 최진호 ,  곽서영 ,  박종상

IPC: C07H19/00

CPC classification number: C12N15/1003

Abstract: PURPOSE: The aim is to provide a bio-inorganic hybrid complex which can carry genetic materials between layers of metal layered double hydroxide by anion exchange reaction. CONSTITUTION: The invention provides the complex of formula I (M2+1-xN3+x(OH)2)(An-)x/n·yH2O, wherein M represents metal cation such as Mg¬2+, Ni¬2+, Cu¬2+ and Zn¬2+ which are alkali-earth metals or transition metals having a valence of two. N represents metal cation such as Al¬3+, Cr¬3+, Fe¬3+, V¬3+ and Ga¬3+ which are transition metal having valence of three. A represents anionic bio-compounds such NO3¬-, CO3¬2-, Cl¬-, SO4¬2-, meta late and organic acid having a valence of n. 0 0. Charge of the layer can be controlled by changing the ratio of the metal according to X. This complex is non-toxic, reversibly dissociated and stable.

Abstract translation: 目的：提供一种可通过阴离子交换反应在金属层状双氢氧化物层之间携带遗传物质的生物 - 无机杂化复合物。 构成：本发明提供式I（M2 + 1-xN3 + x（OH）2）（An-）x / n·yH2O的络合物，其中M表示金属阳离子如Mg 2+，Ni 2+， Cu 2+和Zn 2+是碱土金属或二价过渡金属。 N表示作为三价的过渡金属的金属阳离子，例如Al 3+，Cr 3+，Fe 3+，V 3+和Ga 3+。 A表示阴离子生物化合物，例如NO 3 - ，CO 3 - ，Cl - ，SO 4 2-，间位延迟和n价的有机酸。 0 0.可以通过根据X改变金属的比例来控制层的电荷。该复合物是无毒的，可逆解离和稳定的。