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公开(公告)号：KR1020080009940A
公开(公告)日：2008-01-30
申请号：KR1020060069764
申请日：2006-07-25
Applicant: (주)씨앤팜 , 주식회사 웰스킨 , 이화여자대학교 산학협력단 , 재단법인서울대학교산학협력재단
Abstract: A mixture material is provided to secure more preferable characteristics as a raw material for cosmetic by showing excellent stability, low toxicity, low irritability and good releasing property. A mixture material is characterized in that a skin whitening agent such as 4-n-butylresorcinol, 4-cyclopentylresorcinol, indole-3-acetic acid and retinol is included in a meso-porous inorganic structure made of SiO2 or TiO2. A method for preparing the mixture material comprises a step of absorbing the skin whitening agent into pores of the meso-porous inorganic structure by mixing the mesoporous inorganic structure with a solution of the skin whitening agent. A cosmetic comprises the mixture material.
Abstract translation: 提供混合材料以通过显示出优异的稳定性，低毒性，低易怒性和良好的脱模性来确保作为化妆品原料的更优选的特性。 混合材料的特征在于，由SiO 2或TiO 2制成的中孔多孔无机结构体中包含皮肤增白剂如4-正丁基间苯二酚，4-环戊基间苯二酚，吲哚-3-乙酸和视黄醇。 制备混合物的方法包括通过将介孔无机结构与皮肤增白剂的溶液混合而将皮肤增白剂吸收到中孔多孔无机结构的孔中的步骤。 化妆品包括混合物。
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Patent Agency Ranking
公开(公告)号：KR1020060094745A
公开(公告)日：2006-08-30
申请号：KR1020050016168
申请日：2005-02-25
Applicant: (주)씨앤팜
CPC classification number: A61K33/24 , A61K31/203 , A61K33/08 , A61K33/26 , A61K33/30 , A61K31/07 , A61K47/02 , A61K47/50 , A61K2300/00
Abstract: 본 발명은 기존 레티노익산의 부작용(side-effect)을 제거하고 안정성과 서방성이 우수하고 전달효율을 높힌 새로운 약물 전달 시스템으로서 간암 치료에 탁월한 효과를 나타내는 층상형 금속 수산화물(Layed metal hydroxide)과 레티노익산(Reinoic acid)의 혼성체(LMH-RA)의 약학적 조성물에 관한 것이다.
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公开(公告)号：KR100937205B1
公开(公告)日：2010-01-19
申请号：KR1020070073442
申请日：2007-07-23
Applicant: (주)씨앤팜
IPC: A61K9/18 , A61K9/14 , A61K31/164
Abstract: 본 발명은 활성성분이 생체 친화성 공중합 고분자 계면활성제의 미셀 중에 담지된 활성성분-미셀의 복합체가 메조 다공성 무기 구조체의 동공 중에 혼성화된 혼성물질, 그 제조방법, 및 그 혼성물질을 포함하는 완제품을 제공한다.
메조 다공성 무기 구조체, 혼성 물질, 약물 전달체-
公开(公告)号：KR1020030012641A
公开(公告)日：2003-02-12
申请号：KR1020010046774
申请日：2001-08-02
Applicant: (주)씨앤팜
IPC: C07F19/00
CPC classification number: A61K8/4973 , A23K20/174 , A23L33/15 , A61K8/19
Abstract: PURPOSE: Provided are vitamin-inorganic hybrid which has excellent stability to heat, light and oxygen and excellent dispersibility, and sustainedly releases vitamin to maintain efficacies of vitamin for a ling time, and a preparation thereof. CONSTITUTION: The vitamin-inorganic hybrid complex is characterized by inserting vitamin or its derivative between layers of layered double metal hydroxide as an inorganic carrier by ion exchange reaction. It is represented by the formula:(M¬2+ 1-x N¬3+ x (OH)2)(A¬n-)x/n yH2O.
Abstract translation: 目的：提供维生素 - 无机杂化物，其对热，光和氧具有优异的稳定性和优异的分散性，并持续释放维生素以维持维生素的有效时间及其制备。 构成：维生素 - 无机杂化复合物的特征在于通过离子交换反应将维生素或其衍生物插入作为无机载体的层状双金属氢氧化物层之间。 它由下式表示：（M + 2 + 1-x N-3 + x（OH）2）（A n-）x / n yH 2 O。
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公开(公告)号：KR1020080009653A
公开(公告)日：2008-01-29
申请号：KR1020070073442
申请日：2007-07-23
Applicant: (주)씨앤팜
IPC: A61K9/18 , A61K9/14 , A61K31/164
CPC classification number: A61K9/1611 , A61K9/127 , A61K9/1629 , A61K9/1682 , A61K31/164
Abstract: A mixture material in which a complex of an active ingredient-micelle is hybridized into pores of a meso porous inorganic structure is provided to make a drug be stable at light and heat and show the controlled releasing property, thereby lowering the toxicity of the drug itself and also increasing the transmission efficiency of the drug into cells. A method for preparing the same is provided to simply obtain the mixture material with only two steps. A mixture material is characterized in that a complex of an active ingredient-micelle in which the active ingredient is supported on a micelle of a biocompatible copolymeric polymer surfactant is hybridized with pores of a meso porous inorganic structure, wherein the surfactant is a compound of EOnPOmEOn (n is an integer from 20-106 and m is an integer from 40-100), the meso porous inorganic structure is made of SiO2 or TiO2, and the active ingredient is a water-insoluble drug. A method for preparing the mixture material comprises the steps of: (a) reacting an aqueous solution of a mixture consisting of an active ingredient, a biocompatible copolymeric polymer surfactant with the concentration of more than the critical micelle formation, and an inorganic precursor at a temperature of 25-40 deg.C to form a complex of an active ingredient-micelle in which the active ingredient is supported on the micelle of the surfactant; and (b) subjecting the complex formed aqueous solution to hydrothermal reaction at a temperature of 80-130 deg.C to prepare an organic-inorganic complex.
Abstract translation: 提供其中将活性成分胶束的复合物与中孔多孔无机结构的孔杂交的混合材料，以使药物在光和热下稳定并显示出控制释放性质，从而降低药物本身的毒性 并且还将药物的传播效率提高到细胞中。 提供了制备该方法的方法以简单地仅获得两步的混合材料。 混合材料的特征在于将活性成分 - 胶束的复合物与活性成分负载在生物相容性共聚物表面活性剂的胶束上，与内消旋多孔无机结构的孔杂交，其中表面活性剂是EOnPOmOn的化合物 （n为20〜106的整数，m为40〜100的整数），中空多孔无机结构由SiO 2或TiO 2构成，活性成分为水不溶性药物。 一种制备该混合物材料的方法包括以下步骤：（a）使活性成分，生物相容性共聚物表面活性剂的浓度超过临界胶束形成的混合物的水溶液与无机前体反应， 温度为25-40℃，形成活性成分胶束的复合物，其中活性成分负载在表面活性剂的胶束上; 和（b）使复合物形成的水溶液在80-130℃的温度下进行水热反应以制备有机 - 无机络合物。
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公开(公告)号：KR100443892B1
公开(公告)日：2004-08-09
申请号：KR1020010046774
申请日：2001-08-02
Applicant: (주)씨앤팜
IPC: C07F19/00
Abstract: PURPOSE: Provided are vitamin-inorganic hybrid which has excellent stability to heat, light and oxygen and excellent dispersibility, and sustainedly releases vitamin to maintain efficacies of vitamin for a ling time, and a preparation thereof. CONSTITUTION: The vitamin-inorganic hybrid complex is characterized by inserting vitamin or its derivative between layers of layered double metal hydroxide as an inorganic carrier by ion exchange reaction. It is represented by the formula:(M¬2+ 1-x N¬3+ x (OH)2)(A¬n-)x/n yH2O.
Abstract translation: 用途：提供一种维生素 - 无机杂化剂，其对热，光和氧具有优异的稳定性和优异的分散性，并持续释放维生素以维持维生素的疗效，并提供一种制剂。 组成：维生素 - 无机杂化复合物的特征在于通过离子交换反应将维生素或其衍生物插入层状双金属氢氧化物层之间作为无机载体。 它由下式表示：（M 2+ 2+ 1-x N 3+ x（OH）2）（A n - n - ）x / n y H 2 O.
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