公开(公告)号：KR1020100092224A

公开(公告)日：2010-08-20

申请号：KR1020090011504

申请日：2009-02-12

Applicant: (주)씨앤팜

Inventor： 김지영 ,  박태운 ,  최진호 ,  허현수 ,  김동윤

IPC: A61K47/48 ,  A61P31/04 ,  A61K31/7048

CPC classification number: A61K47/02 ,  A61K9/0053 ,  A61K9/0087 ,  A61K31/7048 ,  A61K47/30 ,  A61K47/36

Abstract: PURPOSE: A hybrid for oral administration without bitter taste of macrolide antibiotics is provided to enough release roxithromycin by inserting macrolide antibiotics into inorganic carrier. CONSTITUTION: A method for manufacturing a hybrid for oral administration without bitter taste of macrolide antibiotics comprises: a step of dissolving aqueous dispersion liquid and macrolide antibiotics in water insoluble organic solvent to obtain hybrid of macrolide antibiotics-silicate; and a step of washing and drying the hybrid with water insoluble organic solvent. The drying is performed by spray drying.

Abstract translation: 目的：通过将大环内酯类抗生素插入无机载体中，提供无大环内酯类抗生素苦味口服的混合物，足以释放罗红霉素。 构成：无大肠杆菌抗生素苦味口服的杂交体的制造方法，其特征在于，将水分散液和大环内酯类抗生素溶解在水不溶性有机溶剂中，得到大环内酯类抗生素 - 硅酸盐的混合物; 以及用水不溶性有机溶剂洗涤和干燥杂化物的步骤。 干燥通过喷雾干燥进行。