公开(公告)号：KR1020050020157A

公开(公告)日：2005-03-04

申请号：KR1020030057890

申请日：2003-08-21

Applicant: (주)씨앤팜

Inventor： 최진호 ,  박태운 ,  허현수

IPC: A61K47/48

CPC classification number: A61K9/1635 ,  A61K9/143 ,  A61K47/50

Abstract: PURPOSE: A hybrid of amlodipine with layered silicate and a preparation process thereof are provided, which hybrid is easily dispersed in aqueous solution to increase bioavailability of amlodipine, and is non-hygroscopic enabling easy manufacturing of formulation. CONSTITUTION: The hybrid of amlodipine with layered silicate is provided, wherein the amlodipine is inserted between layers of silicate; the layered silicate is selected from montmorillonite, beidellite, nontronite, hectorite, saponite, illite, celadonite, gluconite, clay and bentonite; inorganic salt or organic base is added into the hybride in order to regulate release of amlodipine; the organic base is aminoalkyl metacrylate copolymer or polyvinylacetal diethylaminoacetate; and the inorganic salt is selected from calcium salt, sodium salt, potassium salt and ammonium salt. The process for preparing the hybrid of amlodipine with layered silicate comprises the steps of: (1) dispersing the layered silicate in aqueous solution; (2) dissolving amlodipine in ethanol or water; and (3) mixing the layered silicate solution with the amlodipine solution and stirring them.

Abstract translation: 目的：提供氨氯地平与层状硅酸盐的混合物及其制备方法，其混合物容易分散在水溶液中以提高氨氯地平的生物利用度，并且是非吸湿性的，使制剂容易制造。 构成：提供氨氯地平与层状硅酸盐的混合物，其中氨氯地平插入硅酸盐层之间; 层状硅酸盐选自蒙脱石，贝得石，脱镁石，锂蒙脱石，皂石，伊利石，青瓷，葡萄糖甙，粘土和膨润土; 将无机盐或有机碱加入到混合物中以调节氨氯地平的释放; 有机碱是氨基烷基甲基丙烯酸酯共聚物或聚乙烯醇缩二乙基氨基乙酸酯; 无机盐选自钙盐，钠盐，钾盐和铵盐。 制备氨氯地平与层状硅酸盐的混合物的方法包括以下步骤：（1）将层状硅酸盐分散在水溶液中; （2）将氨氯地平溶于乙醇或水中; 和（3）将层状硅酸盐溶液与氨氯地平溶液混合并搅拌。

公开(公告)号：KR1020100092224A

公开(公告)日：2010-08-20

申请号：KR1020090011504

申请日：2009-02-12

Applicant: (주)씨앤팜

Inventor： 김지영 ,  박태운 ,  최진호 ,  허현수 ,  김동윤

IPC: A61K47/48 ,  A61P31/04 ,  A61K31/7048

CPC classification number: A61K47/02 ,  A61K9/0053 ,  A61K9/0087 ,  A61K31/7048 ,  A61K47/30 ,  A61K47/36

Abstract: PURPOSE: A hybrid for oral administration without bitter taste of macrolide antibiotics is provided to enough release roxithromycin by inserting macrolide antibiotics into inorganic carrier. CONSTITUTION: A method for manufacturing a hybrid for oral administration without bitter taste of macrolide antibiotics comprises: a step of dissolving aqueous dispersion liquid and macrolide antibiotics in water insoluble organic solvent to obtain hybrid of macrolide antibiotics-silicate; and a step of washing and drying the hybrid with water insoluble organic solvent. The drying is performed by spray drying.

Abstract translation: 目的：通过将大环内酯类抗生素插入无机载体中，提供无大环内酯类抗生素苦味口服的混合物，足以释放罗红霉素。 构成：无大肠杆菌抗生素苦味口服的杂交体的制造方法，其特征在于，将水分散液和大环内酯类抗生素溶解在水不溶性有机溶剂中，得到大环内酯类抗生素 - 硅酸盐的混合物; 以及用水不溶性有机溶剂洗涤和干燥杂化物的步骤。 干燥通过喷雾干燥进行。