公开(公告)号：KR1020040010306A

公开(公告)日：2004-01-31

申请号：KR1020030050119

申请日：2003-07-22

Applicant: (주)씨앤팜

Inventor： 박태운 ,  정현 ,  김현미 ,  최진호 ,  이지원

IPC: A61K47/02

CPC classification number: A61K31/403 ,  A61K9/143 ,  A61K31/496 ,  A61K38/13

Abstract: PURPOSE: Provided are a hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same, thereby releasing drugs from the layered silicate and maximizing their bioavailability in the living body. CONSTITUTION: A hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate is characterized in that itraconazole, cyclosporine or carvedilol is inserted between silicate layers or absorbed to the surface of the layered silicate. It is manufactured by the steps of: preparing a solution containing layered silicate by dispersing the layered silicate in a water soluble solvent; preparing a drugs-containing solution by dissolving drugs in an organic solvent; and mixing the above solutions together to insert drugs between silicate layers or absorb them to the surface to the surface of the layered silicate.

Abstract translation: 目的：提供伊曲康唑，环孢菌素或卡维地洛与层状硅酸盐的混合物及其制备方法，从而从层状硅酸盐释放药物并使其在生物体中的生物利用度最大化。 构成：伊曲康唑，环孢菌素或卡维地洛与层状硅酸盐的混合物的特征在于，伊曲康唑，环孢菌素或卡维地洛插入硅酸盐层之间或吸收到层状硅酸盐的表面。 通过以下步骤制造：通过将层状硅酸盐分散在水溶性溶剂中来制备含有层状硅酸盐的溶液; 通过将药物溶解在有机溶剂中制备药物溶液; 并将上述溶液混合在一起，将药物插入硅酸盐层之间或将其吸收到层状硅酸盐表面。