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公开(公告)号：KR102224350B1
公开(公告)日：2021-03-09
申请号：KR1020140072766A
申请日：2014-06-16
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/9789 , A61K8/63 , A61K8/673 , A61Q19/02 , A61K2800/75
Abstract: 본 발명은 녹차나무 뿌리 추출물을 유효성분으로 함유하는 피부 자극 완화제 및 이를 포함하는 피부 미백용 화장료 조성물에 관한 것이다.
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公开(公告)号：WO2017057917A1
公开(公告)日：2017-04-06
申请号：PCT/KR2016/010903
申请日：2016-09-29
Applicant: (주)아모레퍼시픽
Abstract: 본 명세서에는, 인간 두피 모사체와 이를 이용한 두피 세정효과의 측정 방법이 개시된다. 본 발명의 일 측면인, 인간 두피 모사체는, 사람의 두피의 구조를 반영하였으므로, 두피 관련 실험에서 유용하게 사용할 수 있다. 구체적으로, 모공간의 간격, 모공의 깊이 및 모공과 모발간의 거리가 실제 사람 두피와 유사하므로, 보다 정확한 실험 결과를 얻을 수 있다. 또한, 제작 비용이 절감되어 경제적이고, 동물의 두피를 사용하지 않아도 되기 때문에, 윤리적 문제로부터 자유롭다.
Abstract translation: 在本说明书中公开的是人类头皮模拟物和通过使用它来测量头皮清洁效果的方法。 作为本发明的一个方面的人类头皮模拟物反映了人的头皮结构，从而可用于与头皮相关的实验中。 特别是，毛孔之间的间隙，孔的深度以及毛孔与头发之间的距离与实际人的头皮相似，因此可以获得更准确的实验结果。 此外，本发明是经济的，因为制造成本降低并且没有伦理问题，因为不需要使用动物的头皮。
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公开(公告)号：WO2013162202A1
公开(公告)日：2013-10-31
申请号：PCT/KR2013/003236
申请日：2013-04-17
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 콩추출물 또는 그의 분획물을 유효성분으로 포함하는 항염증용 조성물에 관한 것으로, 구체적으로, 상기 콩추출물 또는 그의 분획물은 항염활성을 갖는 디펩티드를 포함하는 조성물에 관한 것이다.
Abstract translation: 本发明涉及包含豆提取物或其部分作为活性成分的抗炎组合物，更具体地，涉及包含豆提取物或其部分的包含具有抗炎活性的二肽的组合物。
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公开(公告)号：KR100964428B1
公开(公告)日：2010-06-16
申请号：KR1020080011719
申请日：2008-02-05
Applicant: (주)아모레퍼시픽 , 인제대학교 산학협력단
Abstract: 본 발명은 스트렙토컬론 주벤타스(
Streptocaulon
juventas ) 외 12종의 약용 식물 추출물을 함유함으로써 산화 질소(NO) 매개 염증 및 레티노이드에 의한 피부자극 및 염증을 완화시키는 효과를 가지는 화장료 조성물을 제공한다. 상기 화장료 조성물은 산화질소(NO) 매개 염증과 관련된 피부 질환을 예방할 수 있고, 레티노이드 자극 및 염증으로부터 피부를 보호하고, 염증성 매개분자의 발현을 조절하여 레티노이드에 의한 피부 자극을 완화할 수 있다.
아시아 자생 약용 식물, 레티노이드, 산화 질소, 자극완화, 염증-
公开(公告)号：KR1020090085844A
公开(公告)日：2009-08-10
申请号：KR1020080011719
申请日：2008-02-05
Applicant: (주)아모레퍼시픽 , 인제대학교 산학협력단
Abstract: A composition for relieving skin inflammation is provided to relieve skin irritation and inflammation by nitrogen oxide (NO) and retinoid using 12 kinds of natural medicinal plant extract. A cosmetic composition for relieving skin inflammation comprises one or more kinds selected among Alstonia scholaris, Gomphandra tonkinensis, Asarum petelotii, Pegia sarmentosa, Allium polyrrhizum, Asparagus gobicus Ivanova, Rheum uninerve Maxim, Corispermium mongolicum, Corispermum chinganicum, Salsola monoptera, Jurinea mongolica Maxim and Allium altaicum. The cosmetic composition relieves nitrogen oxide-mediated inflammation and irritiation or inflammation by retinoid. The retinoid is selected from a group of retinol, retinal and retinoic acid.
Abstract translation: 提供缓解皮肤炎症的组合物，通过使用12种天然药用植物提取物，减轻氮氧化物（NO）和类视色素的皮肤刺激和炎症。 用于缓解皮肤炎症的化妆品组合物包括选自Alstonia scholaris，Gomphandra tonkinensis，Asarum petelotii，Pegia sarmentosa，Allium polyrrhizum，Asparagus gobicus Ivanova，Rheum uninerve Maxim，Corisperium mongolicum，Corispermum chinganumum，Salsola monoptera，Jurinea mongolica Maxim和 葱属 化妆品组合物减轻氮氧化物介导的类视黄醇的炎症和刺激或炎症。 类视黄醇选自一组视黄醇，视黄醛和视黄酸。
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Patent Agency Ranking
公开(公告)号：KR1020110042837A
公开(公告)日：2011-04-27
申请号：KR1020090099686
申请日：2009-10-20
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/345 , A61K2800/30 , A61K2800/72 , A61Q19/00
Abstract: PURPOSE: An external use skin composition containing 1,8-octandiol is provided to ensure excellent usage, safety, and preservation and to be applied to cosmetic field. CONSTITUTION: An external use skin composition of low irritation contains 1,8-octandiol without separate preservative ingredients. A cosmetic composition contains the external use skin composition. The cosmetic composition is manufactured in the form of lotion, astringent, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence, or pack.
Abstract translation: 目的：提供含有1,8-辛二醇的外用皮肤组合物，以确保优异的使用，安全性和保存性，并适用于化妆品领域。 构成：低刺激的外用皮肤组合物含有1,8-辛二醇，没有单独的防腐成分。 化妆品组合物含有外用皮肤组合物。 化妆品组合物以洗剂，收敛剂，眼霜，营养霜，按摩膏，清洁霜，清洁泡沫，清洁水，粉末，精华或包装的形式制成。
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公开(公告)号：KR1020100046668A
公开(公告)日：2010-05-07
申请号：KR1020080105619
申请日：2008-10-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An evaluation method is provided to objectively measure the relief effect of sensory skin irritation by quantifying the relief effect of sensory skin irritation about various anti-irritants through the change of concrete threshold. CONSTITUTION: A sensory skin irritation relief effect evaluation method comprises a step of measuring the change of a threshold before and after spreading an anti-irritant to a stimulus applied to the skin sensory nerve. The evaluation method quantitatively measures the change of the threshold by using a device. The evaluation method measures the change of the threshold value about a stimulus applied to at least one skin sensory nerve which is selected in a group which includes Aα, Aβ, Aδ, and C-fiber type. The evaluation method measures the change of the threshold value about a stimulus which is applied to the skin sensory nerve of Aδ or C-fiber type.
Abstract translation: 目的：通过改变混凝土阈值，量化消除各种抗刺激剂对皮肤刺激的缓解作用，提供评估方法，客观地测量感觉皮肤刺激的缓解作用。 构成：感官皮肤刺激缓解效果评估方法包括测量在将抗刺激剂涂抹于皮肤感觉神经的刺激之前和之后的阈值变化的步骤。 评价方法通过使用装置定量地测量阈值的变化。 评估方法测量关于施加到包括Aα，Aβ，Aδ和C纤维类型的组中选择的至少一种皮肤感觉神经的刺激的阈值变化。 评估方法测量施加于Aδ或C纤维类型的皮肤感觉神经的刺激的阈值变化。
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公开(公告)号：KR1020080050786A
公开(公告)日：2008-06-10
申请号：KR1020060121508
申请日：2006-12-04
Applicant: (주)아모레퍼시픽
IPC: A61K31/133
Abstract: A method for inducing itch and a method for screening an itch inhibiting material using glucosylsphingosine are provided to be useful for studying and understanding the itch, thereby being very usefully used for developing a therapeutic agent for the itch and evaluating the effect of a medicine. A method for inducing itch comprises a step of administering at least one compound selected from the group consisting of glucosylsphingosine and a derivative thereof into an animal except human. A method for screening an itch inhibiting material comprises the steps of: (a) administering an itch inhibition candidate material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A method for evaluating the itch inhibition effect comprises the steps of: (a) administering an itch inhibition material to an animal where the itch is induced by administering at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof; and (b) counting a number when the animal scratches. A composition for inducing itch comprises at least one compound selected from the group consisting of the glucosylsphingosine and the derivative thereof as an effective ingredient.
Abstract translation: 提供诱导瘙痒的方法和使用葡糖基鞘氨醇来筛选瘙痒抑制物质的方法，可用于研究和理解瘙痒，从而非常有用地用于开发瘙痒治疗剂并评估药物的效果。 诱导瘙痒的方法包括向除人之外的动物中施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物的步骤。 筛选瘙痒抑制物质的方法包括以下步骤：（a）通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物，向瘙痒诱导的动物施用瘙痒抑制候选物质; 和（b）当动物划伤时计数。 评估瘙痒抑制效果的方法包括以下步骤：（a）向通过施用至少一种选自葡糖基鞘氨醇及其衍生物的化合物诱导瘙痒的动物施用瘙痒抑制物质; 和（b）当动物划伤时计数。 用于诱导瘙痒的组合物包含至少一种选自葡糖基鞘氨醇及其衍生物的化合物作为有效成分。
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公开(公告)号：KR1020080034575A
公开(公告)日：2008-04-22
申请号：KR1020060100703
申请日：2006-10-17
Applicant: (주)아모레퍼시픽
IPC: A61K31/047 , A61K31/13
CPC classification number: A61K31/047
Abstract: A method for inhibiting the expression of CCL27/CTACK(Cutaneous T-cell-attracting chemokine) is provided to regulate SPC(sphingosylphosphorylcholine) inducing expression of CCL27/CTACK, so that the method is useful for prevention and treatment of diseases associated with overexpression of CCL27/CTACK including atopic dermatitis, psoriasis and inflammatory skin disease. The expression of CCL27/CTACK is inhibited by administering an effective amount of sphingosylphosphorylcholine regulator capable of inhibiting activity of SPC or competing with the mechanism of SPC inducing overexpression of CCL27/CTACK to a mammal requiring the expression reduction of CCL27/CTACK. A method for screening the SPC regulator comprises the steps of: (1) treating a testing cell such as keratinocyte with 2-10 muM of SPC or its derivatives to induce overexpression of CCL27/CTACK; and (2) treating the overexpression of CCL27/CTACK-induced cell with a candidate material and measuring the expression inhibition of CCL27/CTACK. Further, the mammal has an atopic dermatitis or psoriasis.
Abstract translation: 提供抑制CCL27 / CTACK（皮肤T细胞吸引趋化因子）表达的方法，以调节诱导CCL27 / CTACK表达的SPC（鞘氨醇磷酰胆碱），从而该方法可用于预防和治疗与过表达相关的疾病 CCL27 / CTACK包括特应性皮炎，牛皮癣和炎性皮肤病。 通过施用有效量的能够抑制SPC活性或与诱导CCL27 / CTACK过表达的SPC的机制竞争需要CCL27 / CTACK表达降低的哺乳动物，CCL27 / CTACK的表达被抑制。 用于筛选SPC调节剂的方法包括以下步骤：（1）用2-10μM的SPC或其衍生物处理测试细胞如角质细胞，以诱导CCL27 / CTACK的过度表达; 和（2）用候选物质治疗CCL27 / CTACK诱导的细胞的过度表达，并测量CCL27 / CTACK的表达抑制。 此外，哺乳动物具有特应性皮炎或牛皮癣。
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公开(公告)号：KR1020070107961A
公开(公告)日：2007-11-08
申请号：KR1020060040588
申请日：2006-05-04
Applicant: (주)아모레퍼시픽
IPC: A61K36/9068 , A61K36/754
CPC classification number: A61K36/00 , A61K8/97 , A61K9/00 , A61K36/754 , A61K36/9062 , A61K36/9068 , A61K2236/33 , A61Q19/00 , A61Q19/005 , Y10S514/857
Abstract: A composition comprising extracts of crude drugs is provided to suppress and relieve itching caused by inflammatory and atopic dermatitis without side effects such as toxicity and skin irritation. A composition for suppressing and relieving itching comprises 0.1-10 wt.% of the extracts of Zingiber officinale Rosc., Evodia officinalis and Alpinia katsumadai Hayata which are prepared by extracting them with water, C1-C4 lower alcohol or a mixed solvent thereof. The daily dosage of crude drug extracts is 0.001-100 mg/kg, preferably 0.1-30 mg/kg and the composition is a pharmaceutical composition having a formulation selected from ointment, plaster, lotion and liniment, or a cosmetic composition having a formulation selected from skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion and body cleanser.
Abstract translation: 提供包含生药提取物的组合物以抑制和缓解由炎性和特应性皮炎引起的瘙痒，而没有副作用，例如毒性和皮肤刺激。 用于抑制和缓解瘙痒的组合物包括通过用水，C1-C4低级醇或其混合溶剂提取它们制备的姜黄提取物的0.1-10重量％的提取物。 生药提取物的日剂量为0.001-100mg / kg，优选0.1-30mg / kg，并且组合物是具有选自软膏，石膏，洗剂和搽剂的制剂的药物组合物或具有选择的制剂的化妆品组合物 从皮肤洗剂，皮肤柔肤剂，皮肤调色剂，收敛剂，乳液，乳液，滋润乳液，营养乳液，按摩霜，营养霜，保湿霜，护手霜，粉底，精华，营养精华，包装，肥皂，清洁泡沫，清洁 洗剂，清洁霜，身体乳液和身体清洁剂。
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