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公开(公告)号：KR1020120119049A
公开(公告)日：2012-10-30
申请号：KR1020110036783
申请日：2011-04-20
Applicant: 강원대학교산학협력단
IPC: C07K16/18 , C12N15/13 , A61K39/395 , A61P29/00
Abstract: PURPOSE: An antibody for C-terminus part protein of PRDM 10 and a manufacturing method thereof are provided to be usefully used for PRDM 10 protein function research. CONSTITUTION: An antibody combined with the C-terminus part protein of PRDM 10 has the sequence number 1(SEQ ID NO:1). The gene which codes the C- terminus protein has the base sequence described in the sequence number 2. The C- terminus protein of the PRDM 10 includes zinc finger motif. A composition for detecting PRDM 10 protein includes the antibody which unites with the C- terminus protein of the PRDM 10. A pharmaceutical composition for treating or preventing PRDM 10 protein related disorder includes PRDM 10 protein includes the antibody which unites with the C- terminus protein of the PRDM 10 and pharmaceutically acceptable carrier. [Reference numerals] (AA) Cloning expression using His tagging system; (BB) Antigen protein purification (IMAC); (CC) Immune reaction induction in vivo of Rabbit
Abstract translation: 目的：提供PRDM 10的C末端部分蛋白的抗体及其制备方法，可用于PRDM 10蛋白质功能研究。 构成：与PRDM 10的C末端部分蛋白结合的抗体具有序列号1（SEQ ID NO：1）。 编码C-末端蛋白的基因具有序列号2中描述的碱基序列.PRDM 10的C-末端蛋白包括锌指基序。 用于检测PRDM 10蛋白的组合物包括与PRDM 10的C-末端蛋白相结合的抗体。用于治疗或预防PRDM 10蛋白相关病症的药物组合物包括PRDM 10蛋白质包括与C-末端蛋白质结合的抗体 的PRDM 10和药学上可接受的载体。 （附图标记）（AA）使用His标签系统的克隆表达; （BB）抗原蛋白纯化（IMAC）; （CC）兔体内免疫反应诱导
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公开(公告)号：KR101046630B1
公开(公告)日：2011-07-05
申请号：KR1020110034161
申请日：2011-04-13
Applicant: 강원대학교산학협력단
IPC: A61K31/7076 , A61K31/70 , A61P35/00
CPC classification number: A61K31/7076
Abstract: PURPOSE: A pharmaceutical composition containing S-adenosyl methionine is provided to relieve pain and side effects for cancer patients. CONSTITUTION: A pharmaceutical composition for cancer cells contains S-adenosyl methionine as an active ingredient. The S-adenosyl prevents an individual from 5-fluorouracil cytotoxic side effects of fluorouracil.
Abstract translation: 目的：提供含有S-腺苷甲硫氨酸的药物组合物，以缓解癌症患者的疼痛和副作用。 构成：用于癌细胞的药物组合物含有S-腺苷甲硫氨酸作为活性成分。 S-腺苷可防止个体患有氟尿嘧啶的5-氟尿嘧啶细胞毒副作用。
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Patent Agency Ranking
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公开(公告)号：KR1020120119061A
公开(公告)日：2012-10-30
申请号：KR1020110036802
申请日：2011-04-20
Applicant: 강원대학교산학협력단
IPC: C07K16/18 , C12N15/13 , A61K39/395 , A61P35/00
Abstract: PURPOSE: An antibody for n-terminus protein of PRDM 10 and a manufacturing method thereof are provided to be usefully used in the PRDM 10 protein function research. CONSTITUTION: An antibody for n-terminus protein of PRDM 10 is described in the sequence number 1(SEQ ID NO:1). The gene which codes the N- terminus protein has the base sequence described in the sequence number 2. The N- terminus protein of the PRDM 10 includes the zinc finger motif. A composition for detecting the PRDM 10 protein includes the antibody which unites with the N- terminus protein of the PRDM 10. The PRDM 10 related disease is inflammatory arthritis or cancer. A manufacturing method of the antibody for N terminus protein of the PRDM 10 comprises the following steps: processing PCR by using a primer in order to amplify the N terminous part of the PRDM 10 by using the PRDM 10 as a mold; ligating the amplified N terminous gene of the PRDM 10 and transforming into a host cell to over express the N-terminous protein of the RPDM 10; and obtaining the antibody for N-terminous protein of the RPDM 10 bt injecting the over expressed N terminus protein of the PRDM 10 into animals. [Reference numerals] (AA) Cloning expression using His tagging system; (BB) Antigen protein purification (IMAC); (CC) Immunization reaction induction inside rabbit body
Abstract translation: 目的：提供PRDM 10的n末端蛋白的抗体及其制备方法，可用于PRDM 10蛋白功能研究。 构成：在序列号1（SEQ ID NO：1）中描述了PRDM 10的n末端蛋白的抗体。 编码N-末端蛋白的基因具有序列号2中描述的碱基序列.PRDM 10的N-末端蛋白包括锌指基序。 用于检测PRDM 10蛋白的组合物包括与PRDM 10的N-末端蛋白相结合的抗体.PCR10相关疾病是炎性关节炎或癌症。 PRDM 10的N末端蛋白的抗体的制造方法包括以下步骤：通过使用底漆处理PCR，以便通过使用PRDM 10作为模具来扩增PRDM 10的N末端部分; 连接PRDM 10的扩增的N末端基因并转化到宿主细胞中以过表达RPDM 10的N末端蛋白; 并获得RPDM10b的N末端蛋白的抗体，将PRDM 10的过表达的N末端蛋白质注入动物体内。 （附图标记）（AA）使用His标签系统的克隆表达; （BB）抗原蛋白纯化（IMAC）; （CC）兔体内免疫反应诱导
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公开(公告)号：KR101029004B1
公开(公告)日：2011-04-14
申请号：KR1020090072354
申请日：2009-08-06
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 염증성 관절염 마커로서 사용 가능한 PRDM10 단백질에 관한 것으로서, 류마티스 관절염 및 강직성 척추염과 같은 염증성 관절염 환자의 혈액 또는 활막액에서는 PRDM10 단백질 발현이 현저히 감소하여 이를 염증성 관절염 진단에 이용할 수 있다.
염증성 관절염, 마커, PRDM10, 류마티스 관절염, 강직성 척추염-
公开(公告)号：KR1020110014812A
公开(公告)日：2011-02-14
申请号：KR1020090072354
申请日：2009-08-06
Applicant: 강원대학교산학협력단
CPC classification number: G01N33/53 , A61K48/00 , C12Q1/6851 , G01N33/5008 , G01N33/6887 , G01N2500/00
Abstract: PURPOSE: A PRDM10 protein as a marker for inflammatory arthritis is provided to diagnose inflammatory arthritis and to develop a therapeutic agent for inflammatory arthritis. CONSTITUTION: A kit for diagnosing inflammatory arthritis contains an antibody which specifically binds to PRDM10 protein. The kit is used for diagnosing inflammatory arthritis by comparing with a control group. The kit is an ELISA kit. The kit comprises a primer for making cDNA corresponding to LCN2 mRNA, reverse transcriptase, Taq polymerase, PCR primer, and dNTP. A target gene PRDM10 for treating or suppressing inflammatory arthritis has a base of sequence number 1 .
Abstract translation: 目的：提供PRDM10蛋白作为炎性关节炎的标志物，用于诊断炎症性关节炎，并开发炎症性关节炎的治疗剂。 构成：用于诊断炎性关节炎的试剂盒含有特异性结合PRDM10蛋白的抗体。 该试剂盒用于通过与对照组比较来诊断炎症性关节炎。 该试剂盒是ELISA试剂盒。 该试剂盒包括用于制备对应于LCN2 mRNA，逆转录酶，Taq聚合酶，PCR引物和dNTP的cDNA的引物。 用于治疗或抑制炎症性关节炎的靶基因PRDM10具有序列号1的碱基。
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