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公开(公告)号：KR1020170087692A
公开(公告)日：2017-07-31
申请号：KR1020160007575
申请日：2016-01-21
Applicant: 강원대학교산학협력단
IPC: G01N33/574 , C12Q1/68 , C12N15/113
Abstract: 본발명은종양환자에대해선별적인항암화학요법을시행하기위한항암제내성진단용바이오마커및 이를이용한항암제내성진단용킷트에관한것이다. 다양한유전자발현변화를조사하기위해총 24,331종의유전자들을대상으로독소루비신, 탁솔, siSETDB1에의해발현이증가한유전자를분석하였다. 독소루비신, 탁솔, siSETDB1에의해서공통으로상향조절된유전자를분석한결과, 222종의유전자가독소루비신과탁솔처리군에서공통적으로발현이증가하였으며, 탁솔과 siSETDB1은 15종의유전자가공통, 독소루비신과 siSETDB1은 24종의유전자가공통이었다. 특히, 독소루비신, 탁솔및 siSETDB1 간에공통적으로발현이증가한유전자는모두 9종이며, 이중에는 FosB, Jun 등과같은발암 AP-1 구성요소들이포함되어있었다.
Abstract translation: 本发明涉及一种抗癌药物有抗性的癌症诊断生物标志物和诊断试剂盒使用相同的免疫力来实现对癌症患者的化疗选择性。 靶基因的基因表达增加的由总共24331种多柔比星，紫杉醇，siSETDB1的分析，以研究各种基因表达变化。 阿霉素，紫杉醇，有人分析常见的siSETDB1上调的基因，它的基因222增加阿霉素和紫杉醇治疗组共同表达，紫杉醇和siSETDB1是常见，多柔比星和siSETDB1的15个基因 共有24个基因。 特别是，通用于多柔比星，紫杉醇和siSETDB1之间所有九个种基因的表达增加，有包含一个双致癌物AP-1组分如FOSB，六月。
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公开(公告)号：KR1020130110344A
公开(公告)日：2013-10-10
申请号：KR1020120032218
申请日：2012-03-29
Applicant: 강원대학교산학협력단
IPC: A23L7/196
Abstract: PURPOSE: A production method of brown rice is provided to offer excellent texture of the brown rice which is easy to be digested by using a simple and economic method. CONSTITUTION: Brown rice is washed. The brown rice is soaked in 25-27°C water for 1-5 hours to absorb 30 wt% of moisture. The brown rice is processed with fiber-degrading enzymes to form micropores on the surface of the brown rice. [Reference numerals] (AA) Normal brown rice on the market; (BB) Brown rice non-enzyme treated; (CC) Good brown rice to eat on the market (cut brown rice); (DD) Enzyme treated brown ric
Abstract translation: 目的：提供糙米的生产方法，提供优质的糙米，易于使用简单经济的方法消化。 构成：糙米被洗涤。 将糙米在25-27℃水中浸泡1-5小时以吸收30重量％的水分。 糙米用纤维降解酶处理，在糙米表面形成微孔。 （参考数字）（AA）市场上的正常糙米; （BB）糙米无酶处理; （CC）好的糙米在市场上吃（切糙米饭）; （DD）酶处理棕色ric
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公开(公告)号：KR1020160126524A
公开(公告)日：2016-11-02
申请号：KR1020150057681
申请日：2015-04-24
Applicant: 강원대학교산학협력단
Abstract: 낭충봉아부패병은토종벌을멸종위기에처하게했던바이러스성질병이다. 낭충봉아부패병의원인체는새크브루드바이러스(SBV)로알려져있는데, 이전연구에의하면, SBV는벌의유충을감염시켜번데기가되기전에죽게함으로써벌의자손수를극심하게줄인다고보고된바 있다. SBV가봉군의한 개체라도감염될경우, 봉군전체에치명적인영향을미치기때문에후속조치를위해서는정확하고빠른진단이필수적이다. 본발명은 SBV에감염된개체를빠르게진단할수 있는방법에관한것이다. 먼저, ssRNA 바이러스인 SBV의표적검출방법으로그 효과가증명된바 있는 RT-PCR 분석을수행하였다. 그러나 SBV의서로다른네 부분을표적으로프라이머를구성하여 RT-PCR 분석을수행한후, 전기영동을통하여확인하였으나특별한산물을얻지못하였다. 더욱정확한결과를위하여 SBV를표적으로한 이중 PCR을수행한결과, 일반 PCR만수행하였을때에는발견되지않았던밴드를확인할수 있었다. 증폭된절편은그 서열을분석을통해새크브루드바이러스의서열과비교하여실험군/대조군의 SBV 감염여부를확인하였다.
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Patent Agency Ranking
公开(公告)号：KR101519402B1
公开(公告)日：2015-05-13
申请号：KR1020130157152
申请日：2013-12-17
Applicant: 강원대학교산학협력단
Abstract: 본발명은쌀눈발아를이용하여 p53 항암단백질을발현하는방법에관한것으로서, 좀더자세히는쌀눈의발아를유도한후 배양하여 p53 항암단백질을생산하는방법에관한것으로간단하고경제적으로단백질치료제를생산할수 있다.
Abstract translation: 本发明涉及使用水稻萌发生产p53抗癌蛋白的方法。 更具体地说，诱导水稻的胚芽发芽并培养以产生p53抗癌蛋白。 根据该方法，可以容易且经济地制造蛋白质处理剂。 该方法包括以下步骤：克隆人p53基因; 得到包含人p53基因的质粒DNA; 发芽糙米 分离糙米的胚芽; 将包含人p53基因的质粒DNA引入胚芽中; 发芽胚芽; 并从发芽的胚芽中提取p53抗癌蛋白。
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公开(公告)号：KR1020120119049A
公开(公告)日：2012-10-30
申请号：KR1020110036783
申请日：2011-04-20
Applicant: 강원대학교산학협력단
IPC: C07K16/18 , C12N15/13 , A61K39/395 , A61P29/00
Abstract: PURPOSE: An antibody for C-terminus part protein of PRDM 10 and a manufacturing method thereof are provided to be usefully used for PRDM 10 protein function research. CONSTITUTION: An antibody combined with the C-terminus part protein of PRDM 10 has the sequence number 1(SEQ ID NO:1). The gene which codes the C- terminus protein has the base sequence described in the sequence number 2. The C- terminus protein of the PRDM 10 includes zinc finger motif. A composition for detecting PRDM 10 protein includes the antibody which unites with the C- terminus protein of the PRDM 10. A pharmaceutical composition for treating or preventing PRDM 10 protein related disorder includes PRDM 10 protein includes the antibody which unites with the C- terminus protein of the PRDM 10 and pharmaceutically acceptable carrier. [Reference numerals] (AA) Cloning expression using His tagging system; (BB) Antigen protein purification (IMAC); (CC) Immune reaction induction in vivo of Rabbit
Abstract translation: 目的：提供PRDM 10的C末端部分蛋白的抗体及其制备方法，可用于PRDM 10蛋白质功能研究。 构成：与PRDM 10的C末端部分蛋白结合的抗体具有序列号1（SEQ ID NO：1）。 编码C-末端蛋白的基因具有序列号2中描述的碱基序列.PRDM 10的C-末端蛋白包括锌指基序。 用于检测PRDM 10蛋白的组合物包括与PRDM 10的C-末端蛋白相结合的抗体。用于治疗或预防PRDM 10蛋白相关病症的药物组合物包括PRDM 10蛋白质包括与C-末端蛋白质结合的抗体 的PRDM 10和药学上可接受的载体。 （附图标记）（AA）使用His标签系统的克隆表达; （BB）抗原蛋白纯化（IMAC）; （CC）兔体内免疫反应诱导
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公开(公告)号：KR1020120067413A
公开(公告)日：2012-06-26
申请号：KR1020100128793
申请日：2010-12-16
Applicant: 강원대학교산학협력단
IPC: A61K51/04 , A61K31/437 , A61K51/00 , A61P35/00
CPC classification number: A61K41/0038 , A61K31/80
Abstract: PURPOSE: A radiotherapeutic adjuvant for breast cancer containing a TLR agonist is provided to remarkably lower survival rate of radiotherapy-resistant breast cancer cells. CONSTITUTION: A radiotherapeutic adjuvant which enhances radiosensitivity of breast cancer cells contains a TLR agonist. The TLR agonist is Poly(I:C) or imiquimode(IMQ) which promotes cell apoptosis induces by autophage. The TLR agonist is pre-treated to breast cancer cells before radiotherapy.
Abstract translation: 目的：提供含有TLR激动剂的乳腺癌放射治疗辅助剂，显着降低放疗耐药乳腺癌细胞存活率。 构成：增强乳腺癌细胞放射敏感性的放射治疗辅助剂含有TLR激动剂。 TLR激动剂是Poly（I：C）或imiquimode（IMQ），其通过自噬促进细胞凋亡。 放射治疗前，对乳腺癌细胞进行TLR激动剂预处理。
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公开(公告)号：KR101046630B1
公开(公告)日：2011-07-05
申请号：KR1020110034161
申请日：2011-04-13
Applicant: 강원대학교산학협력단
IPC: A61K31/7076 , A61K31/70 , A61P35/00
CPC classification number: A61K31/7076
Abstract: PURPOSE: A pharmaceutical composition containing S-adenosyl methionine is provided to relieve pain and side effects for cancer patients. CONSTITUTION: A pharmaceutical composition for cancer cells contains S-adenosyl methionine as an active ingredient. The S-adenosyl prevents an individual from 5-fluorouracil cytotoxic side effects of fluorouracil.
Abstract translation: 目的：提供含有S-腺苷甲硫氨酸的药物组合物，以缓解癌症患者的疼痛和副作用。 构成：用于癌细胞的药物组合物含有S-腺苷甲硫氨酸作为活性成分。 S-腺苷可防止个体患有氟尿嘧啶的5-氟尿嘧啶细胞毒副作用。
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公开(公告)号：KR1020160150195A
公开(公告)日：2016-12-29
申请号：KR1020150087142
申请日：2015-06-19
Applicant: 강원대학교산학협력단
IPC: A01N65/08 , A01N25/00 , A61K36/185
Abstract: 본발명은천연물을주성분으로하는꿀벌친환경방제제에관한것으로서, 좀더 자세히는석류열매추출물및 두충나무추출물중 1종이상을유효성분으로함유하여항바이러스및 항균효과를나타내어친환경적꿀벌질병치료제로사용가능하며, 또한, 본발명의방제제사용으로벌의산란력이높아졌고, 월동력과군세면에서긍정적인효과를나타내었다.
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