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Patent Agency Ranking
公开(公告)号：WO2009108021A2
公开(公告)日：2009-09-03
申请号：PCT/KR2009/000979
申请日：2009-02-27
IPC: C12N15/12
CPC classification number: C07K14/47
Abstract: 본 발명에 따른 과색소침착성 피부 진단용 바이오 마커는 본원 명세서 표 1에 기재된 유전자들로 구성된 군으로부터 선택된 유전자 또는 본원 명세서 표 1에 기재된 단백질들로 구성된 군으로부터 선택된 단백질을 포함하는 것을 특징으로 한다.
Abstract translation: 本发明涉及用于诊断皮肤色素沉着过度的生物标志物，其包含选自表1所列基因的基因或选自表1所列蛋白质的蛋白质。
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公开(公告)号：KR100840144B1
公开(公告)日：2008-06-23
申请号：KR1020070048230
申请日：2007-05-17
Applicant: 경상대학교산학협력단
CPC classification number: G01N33/5008 , C12N15/64
Abstract: A method for screening a material with whitening activity is provided to use an NQ01(NADPH quinone reductase 1) involving with an in vivo pigmentation and having an amino acid sequence of SEQ ID : NO. 1, 2 or 3 or an isoform thereof as a target for screening the material with whitening activity. A method for screening a material with whitening activity comprises the steps of: (a) treating a protein having an amino acid sequence selected from the group consisting of amino acid sequences of SEQ ID : NOs. 1 to 3 with a candidate material; and (b) selecting a material decreasing the activity of the protein by measuring activity change of the protein obtained form the step(a) through a benzo(a)pyrene quinones-reduction analysis or Western blotting.
Abstract translation: 提供用于筛选具有增白活性的材料的方法，以使用涉及体内色素沉着并具有SEQ ID NO：1的氨基酸序列的NQ01（NADPH醌还原酶1）。 1,2或3或其同种型作为筛选具有增白活性的材料的靶标。 用于筛选具有增白活性的材料的方法包括以下步骤：（a）处理具有选自SEQ ID：NO的氨基酸序列的氨基酸序列的蛋白质。 1至3名候选材料; （b）通过苯并（a）芘醌还原分析或Western印迹法测定步骤（a）获得的蛋白质的活性变化来选择降低蛋白质活性的物质。
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公开(公告)号：KR100981816B1
公开(公告)日：2010-09-13
申请号：KR1020080018672
申请日：2008-02-29
Applicant: (주)아모레퍼시픽 , 경상대학교산학협력단
CPC classification number: C07K14/47
Abstract: 본 발명에 따른 과색소침착성 피부 진단용 바이오 마커는 본원 명세서 표 1에 기재된 유전자들로 구성된 군으로부터 선택된 유전자 또는 본원 명세서 표 1에 기재된 단백질들로 구성된 군으로부터 선택된 단백질을 포함하는 것을 특징으로 한다.
과색소침착성, 마커, 유전자, 단백질, 네트워크, 미백제, 스크리닝, 멜라닌-
公开(公告)号：KR1020100058439A
公开(公告)日：2010-06-03
申请号：KR1020100038994
申请日：2010-04-27
Applicant: (주)아모레퍼시픽 , 경상대학교산학협력단
CPC classification number: C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5008 , G01N33/5302 , G01N33/5308
Abstract: PURPOSE: A kit for diagnosing hyperpigmentation is provided to sensitively and quickly predict pigmentation using a marker gene for pigmentation. CONSTITUTION: A kit for diagnosing hyperpigmentation contains a gene selected from gene. The gene expression is enhanced by UV irradiation. A marker for diagnosing hyperpigmentation contains a protein selected from proteins of table 1. The protein expression is also enhanced by UV irradiation. A diagnosis kit contains a polynucleotide having 10 polynucleotides or conplementary polynucleotide thereof, and a solid phase support coupled on the surface. A method for screening a hyperpigmentation inhibitor comprises: a step of treating a test material to the protein and a step of confirming promotion or suppression of protein activation.
Abstract translation: 目的：提供一种用于诊断色素沉着过度的试剂盒，以便使用色素沉着标记基因敏感和快速地预测色素沉着。 构成：用于诊断色素沉着过度的试剂盒含有选自基因的基因。 通过UV照射增强基因表达。 用于诊断色素沉着过度的标记物含有选自表1蛋白质的蛋白质。蛋白质表达也通过UV照射增强。 诊断试剂盒含有具有10个多核苷酸或其互补多核苷酸的多核苷酸，以及耦合在该表面上的固相载体。 用于筛选色素沉着过度抑制剂的方法包括：将测试材料处理到蛋白质的步骤和确认促进或抑制蛋白质活化的步骤。
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公开(公告)号：KR1020090093245A
公开(公告)日：2009-09-02
申请号：KR1020080018672
申请日：2008-02-29
Applicant: (주)아모레퍼시픽 , 경상대학교산학협력단
CPC classification number: C07K14/47 , C12Q1/6876 , C12Q2600/136 , G01N33/5008 , G01N33/68
Abstract: A bio marker for diagnosing hyperpigmentation disposition of skin is provided to rapidly and sensitively predict the possibility of pigmentation. A bio marker for diagnosing skin of hyperpigmentation disposition comprises a gene of which expression is increased or decreased by UV irradiation. A kit for diagnosing hyperpigmentation disposition comprises a polynucleotide of the bio marker gene or its fragment and solid support in which one or more polynucleotide is conjugated on the surface. A method for screening an inhibitor of hyperpigmentation disposition comprises: a step of treating test material in the bio marker gene; and a step of confirming whether the test material suppresses or inhibits the expression of the gene.
Abstract translation: 提供用于诊断皮肤色素沉着过度的生物标记，以快速和敏感地预测色素沉着的可能性。 用于诊断色素沉着过度皮肤的生物标志物包括通过UV照射增加或减少表达的基因。 用于诊断色素沉着过度的试剂盒包括生物标记基因的多核苷酸或其片段和固体支持物，其中一个或多个多核苷酸在表面上缀合。 一种筛选色素沉着过度抑制剂的方法，包括：在生物标记基因中处理试验材料的步骤; 以及确认测试材料是否抑制或抑制基因表达的步骤。
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