-
1.发明授权독활 및 승마 혼합생약추출물을 포함하는 염증관련 질환예방 및 치료용 조성물 有权包含ARALIA CORDATA THUNB混合提取物的组合物。 和CIMICIFUGA HERACLEIFOLIA KOM。 预防和治疗炎症疾病
公开(公告)号：KR100830553B1
公开(公告)日：2008-05-21
申请号：KR1020060124410
申请日：2006-12-08
Applicant: 에스케이케미칼 주식회사 , 경희대학교 산학협력단
Inventor： 박동석 , 유명철 , 최도영 , 이재동 , 양형인 , 백용현 , 허정은 , 김경수 , 조용백 , 한창균 , 이해인 , 정기원 , 유헌승 , 전효진 , 김지홍 , 손현주 , 최상근
IPC: A61K36/237 , A61K36/71 , A61P29/00
CPC classification number: A61K36/71 , A23L33/105 , A23V2002/00 , A61K36/25 , A23V2200/324 , A23V2250/21
Abstract: A composition comprising a mixture crude drug extract of Aralia cordata THUNB. and Cimicifuga heracleifolia Kom. is provided to show cartilaginous tissue protective effect and anti-inflammatory analgesic effect, thereby being used as a composition for preventing inflammation related diseases. A pharmaceutical composition or a health functional food for preventing and treating degenerative arthritis, rheumatoid arthritis, acute pain, chronic pain, arthralgia, neuropathic pain, postoperative pain, migraine, irritable colon syndrome or inflammatory bowel diseases comprises 0.1-50 wt.% of an ethanol extract of a mixture crude drug where a mixture dried weight ratio of Aralia cordata THUNB. and Cimicifuga heracleifolia Kom. is 0.1-10:1 as an effective ingredient.
Abstract translation: 一种组合物，其包含Aralia cordata THUNB的粗制药物提取物的混合物。 和Cimicifuga heracleifolia Kom。 用于显示软骨组织保护作用和消炎镇痛作用，从而用作预防炎症相关疾病的组合物。 用于预防和治疗退行性关节炎，类风湿性关节炎，急性疼痛，慢性疼痛，关节痛，神经性疼痛，术后疼痛，偏头痛，肠易激综合征或炎症性肠病的药物组合物或健康功能性食品包含0.1-50重量％ 乙醇提取物混合物生药，其中混合干燥重量比的Aralia cordata THUNB。 和Cimicifuga heracleifolia Kom。 为0.1-10:1，作为有效成分。
-
公开(公告)号：KR100760386B1
公开(公告)日：2007-09-19
申请号：KR1020060017349
申请日：2006-02-22
Applicant: 경희대학교 산학협력단
Abstract: 본 발명은 독활(
Aralia cordata THUNB.)및 육계
(
Cinnamomum
cassia Presl.) 의 혼합생약추출물을 함유하는 관절염의 예방 및 치료를 위한 조성물에 관한 것으로, 본 발명의 혼합생약추출물은 염증 및 통증 유발 동물모델을 이용한 생체 내 실험에서 탁월한 소염 및 진통 활성을 나타내며, 연골조직에서 인터루킨-1α 로 유도한 프로테오글리칸 분해 및 MMPs의 활성을 탁월히 억제하는 관절보호효과를 나타냄으로써, 관절염의 예방 및 치료에 유용한 약학조성물 및 건강기능식품에 이용될 수 있다.
독활, 육계, 관절염, 관절보호, 진통, 소염, 약학조성물, 건강기능식품-
公开(公告)号：KR100720670B1
公开(公告)日：2007-05-21
申请号：KR1020060017252
申请日：2006-02-22
Applicant: 경희대학교 산학협력단
Inventor： 유명철 , 양형인 , 박동석 , 한정수 , 김경수 , 유미현 , 박은경 , 김영훈 , 이연아 , 이상훈 , 홍승재 , 김남재 , 조용백 , 한창균 , 이해인 , 정기원
IPC: A61K36/75 , A61K36/718 , A61P27/14
Abstract: 본 발명은 황련 및 황백 추출물을 유효성분으로 하는 제IV형 알레르기 및 염증 억제용 조성물을 제공한다.
본 발명의 조성물은 세포독성 없이 활성화된 면역세포 및 대식세포의 증식을 억제하고, 염증 유발 사이토카인의 생성을 억제하며 부종을 억제하는 등 항염효과가 탁월하여 제IV형 알레르기 및 염증 질환의 치료제로 사용될 수 있다.Abstract translation: 本发明提供了用于抑制IV型变态反应和炎症的组合物，其包含当归（Kemke keiskei koidz）提取物。
-
公开(公告)号：KR100683562B1
公开(公告)日：2007-02-15
申请号：KR1020050113071
申请日：2005-11-24
Applicant: 경희대학교 산학협력단
IPC: A61K36/185
Abstract: A composition for preventing and treating arthritis comprising the extract of Betula platyphylla var. japonica is provided to inhibit edema, pain, production of TNF-alpha(tumor necrosis factor-alpha) and NO(nitric oxide), inflammation, decomposition of proteoglycan and collagen, and activity of MMP-13(matrix metalloproteinnase-13) and MMP-3, and reduce cytotoxicity. The composition for preventing and treating arthritis comprises the extract of Betula platyphylla var. japonica, wherein the Betula platyphylla var. japonica extract is prepared with water or C1-C4 lower alcohol; the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis; the composition is a pharmaceutical or health food composition; and the daily dosage of the Betula platyphylla var. japonica extract is 0.001-100 mg/kg.
Abstract translation: 一种用于预防和治疗关节炎的组合物，其包含白桦提取物（Betula platyphylla var。 提供粳稻以抑制水肿，疼痛，TNF-α（肿瘤坏死因子-α）和NO（一氧化氮）的产生，炎症，蛋白多糖和胶原的分解以及MMP-13（基质金属蛋白酶-13）和MMP -3，并降低细胞毒性。 用于预防和治疗关节炎的组合物包含白桦（Betula platyphylla var。 japonica，其中Betula platyphylla var。 粳米提取物用水或C 1 -C 4低级醇制备; 关节炎是退行性关节炎，类风湿性关节炎或狼疮性关节炎; 该组合物是药物或保健食品组合物; 以及白桦（Betula platyphylla var。）的日剂量。 粳米提取物为0.001-100mg / kg。
-
公开(公告)号：KR100821983B1
公开(公告)日：2008-04-15
申请号：KR1020060120714
申请日：2006-12-01
Applicant: 경희대학교 산학협력단
IPC: A61K36/237 , A61P19/02
Abstract: A composition comprising an extract of a mixture crude drug consisting of Aralia cordata THUNB. and Betula platyphylla var. japonica is provided to show excellent cartilage constituents decomposition inhibitory and articular cartilage protecting effects and anti-inflammatory and analgesic activities, thereby being used for preventing and treating articular cartilage damage or arthritis. A pharmaceutical composition for preventing and treating arthritis comprises an ethanol extract of a mixture crude drug consisting of Aralia cordata THUNB. and Betula platyphylla var. japonica in a dried weight ratio of 0.1-10:1, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis.
Abstract translation: 一种组合物，其包含由Aralia cordata THUNB组成的生物药物混合物的提取物。 和Betula platyphylla var。 提供粳稻显示优异的软骨成分分解抑制和关节软骨保护作用和抗炎镇痛活性，从而用于预防和治疗关节软骨损伤或关节炎。 用于预防和治疗关节炎的药物组合物包括由Aralia cordata THUNB组成的混合物制药的乙醇提取物。 和Betula platyphylla var。 粳稻的重量比为0.1-10:1，其中关节炎是退行性关节炎，类风湿性关节炎或狼疮性关节炎。
-
Patent Agency Ranking
公开(公告)号：KR1020070087952A
公开(公告)日：2007-08-29
申请号：KR1020060017350
申请日：2006-02-22
Applicant: 경희대학교 산학협력단
IPC: A61K36/25 , A61K36/489 , A61P19/02
Abstract: Provided is a composition comprising an extract of a mixture consisting of Aralia cordata THUNB. and Sophora subprostrata Chun et T. Chen which shows proteoglycan decomposition inhibition activity, and MMP-1 and MMP-3 activity inhibition effect and has anti-inflammatory and analgesic activity so as to be usefully used as a pharmaceutical composition and a health functional food for preventing and treating arthritis. The composition for preventing and treating arthritis comprises an extract of a mixture consisting of Aralia cordata THUNB. and Sophora subprostrata Chun et T. Chen in a dried weight ratio of 0.1-10:1 as an effective ingredient. To prepare the extract, a polar solvent selected from the group consisting of water, C1-4 lower alcohol, and a mixture thereof is used.
Abstract translation: 本发明提供包含由Aralia cordata THUNB组成的混合物的提取物的组合物。 和Sophora subprostrata Chun et T. Chen，其显示蛋白多糖分解抑制活性，以及MMP-1和MMP-3活性抑制作用，并具有抗炎和止痛活性，以有效地用作药物组合物和用于 预防和治疗关节炎。 用于预防和治疗关节炎的组合物包括由Aralia cordata THUNB组成的混合物的提取物。 和Sophora subprostrata Chun et T. Chen的干重比为0.1-10：1作为有效成分。 为了制备提取物，使用选自水，C 1-4低级醇及其混合物的极性溶剂。
-
公开(公告)号：KR1020070087951A
公开(公告)日：2007-08-29
申请号：KR1020060017349
申请日：2006-02-22
Applicant: 경희대학교 산학협력단
Abstract: Provided is a composition comprising an extract of a mixture consisting of Aralia cordata THUNB. and Cinnamomum cassia Presl. which shows excellent anti-inflammatory and analgesic activity and inhibits the decomposition of proteoglycan and the activity of MMPs so as to prevent and treat arthritis. The composition for preventing and treating arthritis such as osteoarthritis and rheumatoid arthritis comprises an extract of a mixture consisting of Aralia cordata THUNB. and Cinnamomum cassia Presl. in a dried weight ratio of 0.1-10:1 as an effective ingredient. The extract is prepared by using a polar solvent selected from the group consisting of water, C1-4 lower alcohol, and a mixture thereof.
Abstract translation: 本发明提供包含由Aralia cordata THUNB组成的混合物的提取物的组合物。 和肉桂肉桂 其显示出优异的抗炎和止痛活性，并抑制蛋白多糖的分解和MMPs的活性，从而预防和治疗关节炎。 用于预防和治疗诸如骨关节炎和类风湿性关节炎的关节炎的组合物包括由Aralia cordata THUNB组成的混合物的提取物。 和肉桂肉桂 干重比为0.1-10:1作为有效成分。 通过使用选自水，C 1-4低级醇及其混合物的极性溶剂制备提取物。
-
8.发明公开
公开(公告)号：KR1020070087949A
公开(公告)日：2007-08-29
申请号：KR1020060017095
申请日：2006-02-22
Applicant: 경희대학교 산학협력단
Abstract: Provided is a composition comprising an extract of Aralia cordata THUNB. which shows cartilage protecting effect by promoting the expression of cartilage constituting materials and inhibiting the degradation thereof, and has anti-inflammatory and analgesic effect so as to prevent and treat osteoarthritis and rheumatoid arthritis. The composition for preventing and treating articular cartilage injury and arthritis comprises 0.1-50 wt.% of an extract of Aralia cordata THUNB. as an effective ingredient and a pharmaceutically acceptable carrier or an excipient. The extract is prepared by using a polar solvent selected from the group consisting of water, C1-4 lower alcohol, and a mixture thereof.
Abstract translation: 本发明提供一种包含Aralia cordata THUNB提取物的组合物。 通过促进软骨构成材料的表达和抑制其降解来显示软骨保护作用，具有抗炎和镇痛作用，以预防和治疗骨关节炎和类风湿性关节炎。 用于预防和治疗关节软骨损伤和关节炎的组合物包含0.1-50重量％的Aralia cordata THUNB的提取物。 作为有效成分和药学上可接受的载体或赋形剂。 通过使用选自水，C 1-4低级醇及其混合物的极性溶剂制备提取物。
-
公开(公告)号：KR100720671B1
公开(公告)日：2007-05-21
申请号：KR1020060017526
申请日：2006-02-23
Applicant: 경희대학교 산학협력단
Inventor： 유명철 , 양형인 , 박동석 , 한정수 , 김경수 , 유미현 , 박은경 , 김영훈 , 이연아 , 이상훈 , 홍승재 , 김남재 , 조용백 , 한창균 , 이해인 , 정기원
IPC: A61K36/515 , A61K36/752 , A61K36/718 , A61P27/14
Abstract: 본 발명은 진교, 진피 및 황련 추출물을 유효성분으로 하는 제IV형 알레르기 및 염증 억제 및 치료용 조성물을 제공한다.
본 발명의 조성물은 세포독성 없이 활성화된 면역세포의 증식을 억제하고, 염증 유발 사이토카인의 생성을 억제하며 부종을 억제하는 등 항염효과가 탁월하여 제IV형 알레르기 및 염증 질환의 치료제로 사용될 수 있다.Abstract translation: 本发明提供了IV型过敏和炎症的抑制和治疗性组合物用于jingyo，真皮和黄连提取物作为活性成分。
-
10.发明公开독활 및 만형자의 혼합 생약 추출물을 유효성분으로함유하는 관절염의 예방 및 치료용 조성물 无效包含ARALIA CORDATA THUNB和VITEX ROTUNDIFOLIA L.混合提取物的组合物用于预防和治疗ARTHRITIS
公开(公告)号：KR1020080055205A
公开(公告)日：2008-06-19
申请号：KR1020060128211
申请日：2006-12-14
Applicant: 경희대학교 산학협력단
Abstract: A composition comprising the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil is provided to suppress edema and pain, inhibit proteoglycan in articular cartilage cell and activity of MMP-1(matrix metalloproteinase-1) and MMP-3, and induce no cytotoxicity and morphological change, so that the composition is useful for preventing and treating arthritis. A pharmaceutical or health food composition for preventing and treating arthritis comprises 0.1-50 wt.% of the mixed extracts of Aralia cordata THUNB and Vitex rotundifolia L. fil which are prepared by extracting them with water, C1-C4 lower alcohol including methanol or ethanol, or a mixed solvent thereof, wherein the arthritis is degenerative arthritis, rheumatoid arthritis or Lupus arthritis; and the daily dosage of the mixed extracts is 0.01mg/kg-10g/kg, preferably 1 mg/kg-1g/kg.
Abstract translation: 提供包含Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的组合物，以抑制水肿和疼痛，抑制关节软骨细胞中的蛋白聚糖和MMP-1（基质金属蛋白酶-1）和MMP-3的活性，并诱导无 细胞毒性和形态变化，使得该组合物可用于预防和治疗关节炎。 用于预防和治疗关节炎的药物或保健食品组合物包括通过用水，C1-C4低级醇（包括甲醇或乙醇）提取它们制备的Aralia cordata THUNB和Vitex rotundifolia L. fil的混合提取物的0.1-50重量％ 或其混合溶剂，其中所述关节炎是退行性关节炎，类风湿性关节炎或狼疮性关节炎; 混合提取物的日剂量为0.01mg / kg-10g / kg，优选为1mg / kg-1g / kg。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.027 seconds)
