백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌
    1.
    发明公开
    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌 有权
    (4E,6E,2S,3R)-2-N-DOCOSANOY-4,6-TETRADECASPHINGADIENINE从BEAUVERIA BASSIANA 101A分离和纯化

    公开(公告)号:KR1020040012398A

    公开(公告)日:2004-02-11

    申请号:KR1020020045968

    申请日:2002-08-03

    Abstract: PURPOSE: Provided is new sphingolipid, (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine which is isolated and purified from Beauveria bassiana 101A and has prevention and treatment effects on degenerative brain diseases. CONSTITUTION: New sphingolipid, (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine is isolated and purified from Beauveria bassiana 101A and has prevention and treatment effects on degenerative brain diseases. It is characteristically represented by the formula(1). A pharmaceutical preparation for prevention and treatment of brain diseases characteristically contains (4E, 6E, 2S, 3R)-2-N-Docosanoyl-4,6-tetradecasphingadienine as an active ingredient.

    Abstract translation: 目的:提供从Beauveria bassiana 101A分离纯化的新型鞘脂(4E,6E,2S,3R)-2-N-二十二烷基-4,6-十四碳环糊精,并对退行性脑病具有预防和治疗作用。 构成:新型鞘脂(4E,6E,2S,3R)-2-N-二十二烷基-4,6-十四碳二烯雌酚从白僵菌101A中分离纯化,对退行性脑病具有预防和治疗作用。 它由式(1)表征。 用于预防和治疗脑疾病的药物制剂特征性地含有(4E,6E,2S,3R)-2-N-二十一烷酰基-4,6-十四碳环糊精作为活性成分。

    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌
    2.
    发明授权
    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌 有权
    具有增强神经突生长的白僵菌101A的新型鞘脂,4E,6E,2S,3R-2-N-二十二烷基-4,6-十四碳环己二烯

    公开(公告)号:KR100487113B1

    公开(公告)日:2005-05-03

    申请号:KR1020020045968

    申请日:2002-08-03

    Abstract: 본 발명은 신경세포 성장 및 분화와 관련된 퇴행성 뇌질환을 치료 및 예방하기 위하여 백강잠 101A(
    Beauveria bassiana 101A)의 추출물로부터 분리, 정제한 뇌신경활성 물질인 (4E, 6E, 2S, 3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌이 퇴행성 뇌질환의 예방 및 치료제로 개발될 수 있도록 하는데 그 목적이 있다.
    본 발명에서는 백강잠
    101A의 추출물과 이의 활성성분에 대하여 퇴행성 뇌질환에 중요하게 관여하는 신경세포 축색돌기 성장촉진 및 신경영양인자 단백질 증강효과를 PC 12 세포를 이용하여 검색한 결과 증강 및 신경세포 성장 촉진에 탁월한 작용을 가지면서 세포독성은 없는 백강잠
    101A로부터 분리한 신규화합물인 (4E, 6E, 2S, 3R)-2-N-도코사노일-4,6-테트라데카스핀가디에닌을 제공함으로써 알쯔하이머, 파킨슨 및 중풍과 같은 퇴행성 뇌질환에 의하여 유발되는 신경세포 위축 및 손상을 경감시켰으며, 아울러 국민건강 증진과 양잠농가의 새로운 소득원으로의 역할이 기대된다.

    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌
    3.
    发明授权
    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌 有权
    一种具有增强神经突生长的白僵菌101A的新型鞘脂,4E,6E,2S,3R-2-N-二十烷基-4,6-十四碳四烯酸鞘磷酯

    公开(公告)号:KR100487112B1

    公开(公告)日:2005-05-03

    申请号:KR1020020045967

    申请日:2002-08-03

    Abstract: 본 발명은 신경세포성장 및 분화와 관련된 퇴행성 뇌질환을 치료 및 예방하기 위하여 백강잠 101A(
    Beauveria bassiana 101A)의 추출물로부터 분리, 정제한 신규 뇌신경활성 물질인 (4E, 6E, 2S, 3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌 및 그 약제학적 제제에 관한 것이다.
    본 발명에서는 백강잠
    101A의 추출물과 이의 활성성분에 대하여 퇴행성 뇌질환에 중요하게 관여하는 신경세포 축색돌기 성장촉진 및 신경영양인자 단백질 증강효과를 PC 12 세포를 이용하여 검색한 결과 증강 및 신경세포 성장 촉진에 탁월한 작용을 가지면서 세포독성은 없는 백강잠 101A로부터 분리한 신규화합물인 (4E, 6E, 2S, 3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌을 제공함으로써 알쯔하이머, 파킨슨 및 중풍과 같은 퇴행성 뇌질환에 의하여 유발되는 신경세포 위축 및 손상을 경감시켰으며, 아울러 국민건강 증진과 양잠농가의 새로운 소득원으로의 역할이 기대된다.

    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌
    4.
    发明公开
    백강잠 101A로부터 분리, 정제한 뇌신경성장 촉진물질(4E, 6E, 2S,3R)-2-N-아이코사노일-4,6-테트라데카스핀게닌 有权
    (4E,6E,2S,3R)-2-N-异丙基-4,6-四氮杂-苯胺,从BEAUVERIA BASSIANA 101A中分离和纯化

    公开(公告)号:KR1020040012397A

    公开(公告)日:2004-02-11

    申请号:KR1020020045967

    申请日:2002-08-03

    Abstract: PURPOSE: Provided is new sphingolipid, (4E, 6E, 2S, 3R)-2-N-Eicosanoyl-4,6-tetradecasphinganine, which is isolated and purified from Beauveria bassiana 101A and prevents and treats degenerative brain diseases. CONSTITUTION: New sphingolipid, (4E, 6E, 2S, 3R)-2-N-Eicosanoyl-4,6-tetradecasphinganine is represented by the formula(1). It is isolated and purified from Beauveria bassiana 101A and has prevention and treatment effects on degenerative stroke. A pharmaceutical preparation for prevention and treatment of brain diseases is characterized by containing (4E, 6E, 2S, 3R)-2-N-Eicosanoyl-4,6-tetradecasphinganine, as an active ingredient.

    Abstract translation: 目的:提供新的鞘脂(4E,6E,2S,3R)-2-N-二十烷基-4,6-十四碳七烯素,其从白僵菌101A分离和纯化并预防和治疗退行性脑疾病。 构成:新型鞘脂(4E,6E,2S,3R)-2-N-二十烷基-4,6-十四碳七氢化合物由式(1)表示。 从Beauveria bassiana 101A中分离纯化,对退行性卒中有预防和治疗作用。 用于预防和治疗脑疾病的药物制剂的特征在于含有作为活性成分的(4E,6E,2S,3R)-2-N-二十烷基-4,6-十四碳八氢嘌呤。

    익은누에 동결건조에 의한 실샘분리 방법 및 실샘분말 제조방법
    7.
    发明公开
    익은누에 동결건조에 의한 실샘분리 방법 및 실샘분말 제조방법 有权
    SILK-GLAND分离方法和从成熟丝绸制成丝状粉末的方法

    公开(公告)号:KR1020110044085A

    公开(公告)日:2011-04-28

    申请号:KR1020090100905

    申请日:2009-10-22

    CPC classification number: A23B4/037 A23B4/06 A23L3/36 A23L3/44

    Abstract: PURPOSE: A producing method of silk gland powder of matured silkworms is provided to easily obtain the silk gland powder by collecting silkworms right before a pupae stage. CONSTITUTION: A producing method of silk gland powder of matured silkworms comprises the following steps: breeding silkworms until the fifth instar, to obtain the matured silkworms; rapidly freezing the matured silkworms with liquid nitrogen, and storing; freeze-drying the matured silkworms; separating silk glands from the freeze-dried silkworms; and crushing the obtained silk glands.

    Abstract translation: 目的:提供成熟蚕丝腺粉的生产方法,通过在蛹期前收集蚕丝,轻松获得丝腺粉末。 构成:成熟蚕丝腺粉的制备方法,包括以下步骤:将蚕培养至五龄,获得成熟蚕; 用液氮快速冷冻成熟的蚕,储存; 冷冻成熟的蚕; 从冷冻干蚕分离丝腺; 并粉碎获得的丝腺。

    은 나노입자를 함유한 천연실크 및 그의 제조방법
    8.
    发明授权
    은 나노입자를 함유한 천연실크 및 그의 제조방법 有权
    制备纳米颗粒的天然丝绸的方法

    公开(公告)号:KR100835207B1

    公开(公告)日:2008-06-09

    申请号:KR1020070053289

    申请日:2007-05-31

    Abstract: A process for preparation of the natural silk including silver nano-particle is provided to obtain silk fabric having antibiotic and disinfectant properties by breeding silkworm with silver nano-particle included feed, and to apply to various health goods. A silver nano-particle powder is sprayed on the mulberry leaves. A natural silk is obtained by breeding silkworm with mulberry leaves including the silver nano-particle. A silver nano-particle included spray is manufactured in first process. The feed of the silkworm is produced using the silver nano-particle spray in second process. The silkworm is bred with mixture of the silver nano-particle solution and the feed of the silkworm. The barrel type stirrer having sufficient depth according to the spray particle, and stirring three dimensionally is used in the evaporation process of the nano-particle. Magnetron sputter, ion beam sputter, resistance heating using DC(Direct Current)/RF(Radio Frequency) power, PVD(Physical Vapor Deposition) or CVD (Chemical Vapor Deposition) is used in the vacuum evaporation method.

    Abstract translation: 提供包含银纳米颗粒的天然丝绸的制备方法,通过用含有纳米颗粒的饲料喂养蚕桑,得到具有抗生素和消毒剂特性的丝织物,并适用于各种保健品。 将银纳米颗粒粉末喷洒在桑叶上。 通过用包含银纳米颗粒的桑叶培育桑蚕获得天然丝。 首先制造含有纳米粒子的喷雾剂。 在第二种方法中,使用银纳米颗粒喷雾制备蚕的饲料。 家蚕用银纳米颗粒溶液和蚕饲料混合培育。 在纳米颗粒的蒸发过程中使用具有根据喷雾颗粒具有足够深度并且三维搅拌的桶型搅拌器。 在真空蒸发法中使用磁控管溅射,离子束溅射,使用DC(直流)/ RF(射频)功率,PVD(物理气相沉积)或CVD(化学气相沉积)的电阻加热。

    뇌신경성장인자 증강작용을 갖는 백강잠 추출물 및 이의활성성분을 함유하는 약학적 제제
    9.
    发明公开
    뇌신경성장인자 증강작용을 갖는 백강잠 추출물 및 이의활성성분을 함유하는 약학적 제제 无效
    BEAUVERIA BASSIANA提取具有神经生长因子增强活性和含有其的药物组合物

    公开(公告)号:KR1020040012396A

    公开(公告)日:2004-02-11

    申请号:KR1020020045966

    申请日:2002-08-03

    Abstract: PURPOSE: Provided is a beauveria bassiana 101A extract containing an active compound which has excellent activity in nerve cell outgrowth without cytotoxicity. The extract and active compound separated therefrom can reduce atrophy and damages caused by degenerative cerebral diseases including Parkinson's disease and stroke. CONSTITUTION: The active compound from beauveria bassiana extract is represented by formula 1, wherein R is C17 or C19 of alkyl group. The pharmaceutical composition using the active compound from beauveria bassiana extract for treatment or prophylaxis of cerebral diseases comprises one or more selected from a group consisting of 1,7-dimethyl-xanthine, uracil, urea, betain, and tyrosine, as an active compound.

    Abstract translation: 目的:本发明提供一种含有活性化合物的白僵菌101A提取物,其在没有细胞毒性的神经细胞生长中具有优异的活性。 从其分离的提取物和活性化合物可以减少由退行性脑疾病(包括帕金森病和中风)引起的萎缩和损伤。 构成:来自白僵菌提取物的活性化合物由式1表示,其中R为烷基的C17或C19。 使用白僵菌提取物的活性化合物用于治疗或预防脑疾病的药物组合物包含选自1-7-二甲基 - 黄嘌呤,尿嘧啶,尿素,甜菜碱和酪氨酸作为活性化合物的一种或多种。

    누에분말을 이용한 곤충기생균 배지 조제방법
    10.
    发明授权
    누에분말을 이용한 곤충기생균 배지 조제방법 有权
    根据使用者的需求而定

    公开(公告)号:KR100382166B1

    公开(公告)日:2003-04-26

    申请号:KR1020010007899

    申请日:2001-02-16

    Abstract: PURPOSE: Provided is a preparation method of a medium for Entomopathogenic fungi effectively and economically by using silkworm powder used as a hypoglycemic agent. The medium increases the growth rate of Entomopathogenic fungi. CONSTITUTION: The medium for Entomopathogenic fungi is characterized by dissolving 24g of silkworm powder in 1L of distilled water; sterilizing it at 121 deg.C for 15 minutes; filtering the sterilized solution with gauze and a sieve sequentially; adding 15g of agar the pure solution; sterilizing it; and pipetting 21mL of the solution into each petridish the solidifying them.

    Abstract translation: 用途:本发明提供一种利用蚕粉作为降血糖剂有效经济地制备用于昆虫病原真菌的培养基的方法。 培养基增加了Entomopathogenic真菌的生长速度。 构成:昆虫病原真菌的培养基的特征是将24g家蚕粉溶于1L蒸馏水中; 在121℃灭菌15分钟; 依次用纱布和筛子过滤灭菌的溶液; 加入15g琼脂纯溶液; 消毒; 并将21mL溶液移入每个培养皿中使其固化。

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