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公开(公告)号：WO2014077487A1
公开(公告)日：2014-05-22
申请号：PCT/KR2013/006594
申请日：2013-07-23
Applicant: 목포대학교산학협력단
IPC: A61K36/185 , A61P3/10 , A61P3/00
CPC classification number: A61K36/21 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K9/14 , A61K47/36
Abstract: 본 발명은 칠면초를 유효성분으로 하는 당뇨병 예방 또는 개선용 식품 조성물 및 이의 제조방법에 관한 것이다. 본 발명의 칠면초 분말은 CCK-1 유전자의 결함으로 인해 성장하는 동안 자발적으로 비만과 당뇨가 유발되는 OLEFT쥐에 섭취시킬 경우 혈당 상승 및 당화혈색소 생성을 억제시키고 포도당 부하 내성에 개선 효과를 나타냈으며 인슐린 감수성 개선 및 당 대사 기능의 회복에 관여하는 아디포넥틴이 혈중 높게 유지되고, 췌장 β-세포 보호 효과를 갖는 항당뇨 활성, 구체적으로 당뇨 개선 또는 예방 효과가 우수할 뿐만 아니라, 천연물질을 유효성분으로 하는 것으로 내성이나 안전성과 관련된 문제가 발생되지 아니하므로, 상기 당뇨병 예방 또는 개선용 식품 조성물은 당뇨병의 치료, 예방 또는 완화를 위한 다양한 용도로 널리 사용될 수 있다.
Abstract translation: 本发明涉及含有Su ica作为预防或缓解糖尿病的活性成分的食品组合物及其制备方法。 本发明的Su ica粉末由于CCK-1基因的缺陷而在生长期间天然诱导肥胖和糖尿病的OLEFT小鼠施用时，血糖的升高和糖化血红蛋白的产生被抑制， 显示出改善葡萄糖耐量的方法。 此外，维持与胰岛素敏感性的提高和葡萄糖代谢功能的恢复有关的脂联素的高血糖水平，以及对胰腺细胞具有保护作用的抗糖尿病活性，具体地说，减轻或 预防糖尿病，优良。 此外，由于本发明包含天然物质作为活性成分，因此不会发生与电阻和安全性相关的问题。 因此，用于预防或减轻糖尿病的食品组合物可以以各种方式广泛使用以治疗，预防或减轻糖尿病。 [代表图]图2
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公开(公告)号：KR1020140063952A
公开(公告)日：2014-05-28
申请号：KR1020120130701
申请日：2012-11-19
Applicant: 목포대학교산학협력단
IPC: A61K36/185 , A61P3/10 , A61P3/00
CPC classification number: A61K36/21 , A23L2/02 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K9/14 , A61K47/36
Abstract: The present invention relates to a composition for preventing diabetes, comprising a Suaeda japonica juice powder and having an effect of preventing pancreatic β-cell destruction, and a method for preparing the same. More specifically, when OLETF mice with obesity and diabetes naturally induced during growth due to a genetic defect of the CCK-1 receptor were fed a Suaeda japonica juice powder prepared by obtaining a juice from fresh Suaeda japonica then spraying and drying the juice, an effect of reducing pancreatic β-cell dysfunction and destruction resulting from insulin resistance and hyperinsulinemia was confirmed. Therefore, the Suaeda japonica juice powder not only delays the progress of insulin resistance and type 2 diabetes, but also has an excellent effect of preventing pancreatic β-cell destruction.
Abstract translation: 本发明涉及用于预防糖尿病的组合物，其包含Su ica汁粉末并具有防止胰腺β-细胞破坏的作用及其制备方法。 更具体地说，当由于CCK-1受体的遗传缺陷而在生长期间自然诱导的肥胖和糖尿病的OLETF小鼠喂养通过从新鲜Su by获得汁液制备的Su粳汁粉末，然后喷雾和干燥果汁，效果 证实了减少胰岛β细胞功能障碍和由胰岛素抵抗和高胰岛素血症引起的破坏。 因此，Su ica汁不仅延缓了胰岛素抵抗和2型糖尿病的进展，而且具有预防胰腺β细胞破坏的良好效果。
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公开(公告)号：KR1020140063113A
公开(公告)日：2014-05-27
申请号：KR1020120130078
申请日：2012-11-16
Applicant: 목포대학교산학협력단
IPC: A61K36/185 , A61P3/10 , A61P3/00
Abstract: The present invention relates to a medicinal composition for treating or preventing diabetes and a functional composition for improving or preventing diabetes containing Spergularia marina as an active ingredient. Since the Spergularia marina is very effective in improving insulin sensitivity, the present invention in this respect can be a functional composition containing the Spergularia marina as the active ingredient for improving insulin sensitivity. The Spergularia marina is a natural product has been used as a food ingredient, thereby being judged to have no problems involved in tolerance or safety. In addition, the Spergularia marina is very effective in reducing the blood glucose level and improving the insulin sensitivity, thereby being able to be widely used for various purposes to treat, prevent, or relieve diabetes.
Abstract translation: 本发明涉及用于治疗或预防糖尿病的药物组合物和用于改善或预防糖尿病的功能组合物，所述糖尿病含有作为活性成分的精液。 由于精液型泳池在提高胰岛素敏感性方面非常有效，所以本发明在这方面可以是含有作为提高胰岛素敏感性的活性成分的精神分裂杆菌的功能性组合物。 Spergularia码头是一种天然产品，已被用作食品成分，因此被认为没有涉及容忍或安全的问题。 另外，斯曲格马林在降低血糖水平和提高胰岛素敏感性方面非常有效，因此能广泛用于治疗，预防或缓解糖尿病的各种用途。
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公开(公告)号：KR101261029B1
公开(公告)日：2013-05-06
申请号：KR1020110117721
申请日：2011-11-11
Applicant: 목포대학교산학협력단
CPC classification number: A23L33/105 , A23L3/46 , A23V2002/00 , A23V2200/328 , A23V2250/21 , A23V2300/14
Abstract: PURPOSE: A functional food composition for diabetes prevention or alleviation containing natural materials is provided to maintain the high insulin content in blood, and to show an insulin resistance reduction effect while scarcely having side effects. CONSTITUTION: A functional food composition for diabetes prevention or alleviation includes Suaeda japonica. Suaeda japonica is Suaeda japonica powder. The Suaeda japonica powder is a spray-dried material of Suaeda japonica juice. Suaeda japonica is washed to remove foreign substances. The Suaeda japonica without the foreign substances is juice extracted using a squeezer. A mixture is manufactured by adding dextran to the juice. The mixture is spray-dried to remove the powder. [Reference numerals] (AA) Blood sugar concentration(mg/dl); (BB) Age(weeks)
Abstract translation: 目的：提供含有天然物质的糖尿病预防或缓解的功能性食品组合物，以维持血液中高胰岛素含量，并显示胰岛素抵抗降低作用，同时几乎没有副作用。 构成：用于糖尿病预防或缓解的功能性食物组合物包括Su includes（Suaeda japonica）。 a a是Su ica粉。 Suaeda japonica粉是Suaeda japonica汁的喷雾干燥材料。 洗涤Su to以除去异物。 没有异物的Su is是使用挤压机提取的果汁。 通过在果汁中加入葡聚糖来制造混合物。 将混合物喷雾干燥以除去粉末。 （AA）血糖浓度（mg / dl） （BB）年龄（周）
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