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公开(公告)号：KR1020070099995A
公开(公告)日：2007-10-10
申请号：KR1020060031491
申请日：2006-04-06
Applicant: 삼성전자주식회사
CPC classification number: B04B5/02 , B04B13/00 , G01N15/042 , G01N15/05 , G01N21/07 , G01N33/491
Abstract: A device and a method for separating materials according to the size by centrifugal force are provided to detect easily the separated materials with an optical detector by holding specific materials on a rotary plate. A centrifugal separator for separating materials according to the size as well as weight has a rotary drum(14) turning around a second rotary shaft(12) vertical to a first rotary shaft(10). The rotary drum is composed of: a sample injection port; at least one rotary plate radially extended from the second rotary shaft toward the inner surface of the rotary drum to receive the sample on the surface; and a discharge port for discharging the separated sample. The rotary plate has at least one selected from a group comprising protruded and recessed parts, on the surface.
Abstract translation: 提供了一种通过离心力分离尺寸的材料分离装置和方法，通过将特定材料保持在旋转板上，容易地利用光学检测器检测分离的材料。 用于根据尺寸和重量分离材料的离心分离器具有围绕垂直于第一旋转轴（10）的第二旋转轴（12）转动的旋转滚筒（14）。 旋转鼓由以下部件组成：样品注射口; 至少一个旋转板从所述第二旋转轴径向延伸到所述旋转滚筒的内表面以接收所述表面上的样品; 以及用于排出分离的样品的排出口。 旋转板在表面上具有选自包括突出部分和凹陷部分的组中的至少一个。
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公开(公告)号：KR1020080028703A
公开(公告)日：2008-04-01
申请号：KR1020060094341
申请日：2006-09-27
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6806 , B82B3/0014
Abstract: A device for purifying nucleic acids is provided to increase the surface area of a hydrophilic substrate significantly, where the nucleic acids are coupled, by introducing a nano-wire layer grown from the hydrophilic substrate, thereby purifying the nucleic acids efficiently and rapidly. A device for purifying nucleic acids includes a solid substrate where a nano-wire layer is existing, wherein the nano-wire layer is formed by a nano-wire being grown from the solid substrate having a hydrophilic functional group on the surface thereof. The device further comprises a solution storage portion which is communicated with the solid substrate through a microchannel and supplies a kosmotropic salt to the solid substrate or a nucleic acid eluting buffer solution storage portion which is communicated to the solid substrate through a microchannel and supplies a nucleic acid elution buffer solution to the solid substrate. The lab-on-a-chip comprises the device. A method for purifying the nucleic acids comprises a step of contacting a solution including a sample containing the nucleic acids and a kosmotropic salt with the nano-wire layer on the substrate to couple the nucleic acids to the nano-wire layer. Further, the solid substrate is silicon substrate.
Abstract translation: 提供用于纯化核酸的装置，通过引入从亲水底物生长的纳米线层，显着提高亲水底物的表面积，其中核酸被偶联，从而有效和快速地纯化核酸。 用于纯化核酸的装置包括其中存在纳米线层的固体基质，其中纳米线层由其表面上具有亲水性官能团的固体基质生长的纳米线形成。 该装置还包括溶液储存部分，该溶液储存部分通过微通道与固体基质连通，并向固体底物或核酸洗脱缓冲溶液储存部分提供可选择性盐，或通过微通道与固体基质连接并提供核酸 酸洗缓冲液至固体底物。 该芯片实验室包括该设备。 纯化核酸的方法包括使包含核酸的样品和离液性盐的溶液与基底上的纳米线层接触以将核酸耦合到纳米线层的步骤。 此外，固体基板是硅基板。
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公开(公告)号：KR1020070112654A
公开(公告)日：2007-11-27
申请号：KR1020060045812
申请日：2006-05-22
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6806 , B01L3/5027 , B01L3/5088 , C12Q1/686 , C12Q1/6837 , C12Q2527/125 , C12Q2537/149 , C12Q2565/629
Abstract: A method and an apparatus for concentrating and amplifying nucleic acids in a single micro-chamber are provided to show higher PCR yield due to the nucleic acids reversibly bound to the surface of the micro-chamber compared to the aluminium oxide surface where an irreversible binding occurs, save samples and consumption goods and reduce time and labor required for treatment and analysis since all steps are continuously done in a same micro-chamber, increase the sensitivity by omitting a sample transferring step, significantly lower the danger of cross-contamination and be easy to construct a completely automated system. A method for continuously concentrating and amplifying nucleic acids in a micro-chamber comprises the steps of: introducing a solution including a sample containing nucleic acids and a kosmotropic salt such as sulfate, phosphate, hydroxide, fluoride, formate, and acetate into the microchamber having a hydrophilic functional group on the surface so as to react the nucleic acids with the surface, thereby binding the nucleic acids to the surface to concentrate the nucleic acids; and adding a PCR mixture to the chamber to perform a PCR. An apparatus for continuously performing concentration and amplification of nucleic acids comprises a microchamber having a hydrophilic functional group on the surface; a sample storage portion which is communicated with the micro-chamber through a micro-channel and supplies a sample including the nucleic acids to the micro-chamber; a kosmotropic salt solution storage portion which is communicated with the microchamber through the micro-channel and supplies a kosmotropic salt to the micro-chamber; a PCR mixture storage portion which is communicated with the microchamber through the micro-channel and supplies a PCR mixture to the micro-chamber; and a heating and cooling portion which heats and cools the micro-chamber.
Abstract translation: 提供了用于浓缩和扩增单个微室中的核酸的方法和装置，以显示较高的PCR产量，这是由于核酸与可能发生不可逆结合的氧化铝表面相比可逆地结合到微室表面 ，节省样品和消费品，减少处理和分析所需的时间和劳动力，因为所有步骤都在同一个微室中连续进行，通过省略样品转移步骤提高灵敏度，显着降低交叉污染的危险，并且易于 构建一个完全自动化的系统。 一种用于在微室中连续浓缩和扩增核酸的方法包括以下步骤：将包含含有核酸的样品和诸如硫酸盐，磷酸盐，氢氧化物，氟化物，甲酸盐和乙酸盐等去离子盐的样品引入具有 表面上的亲水性官能团以使核酸与表面反应，从而将核酸与表面结合以浓缩核酸; 并向室中加入PCR混合物进行PCR。 用于连续进行核酸浓缩和扩增的装置包括在表面上具有亲水性官能团的微室; 样品存储部分，其通过微通道与微室连通并将包含核酸的样品供应到微室; 通过微通道与小室连通并向微室供给去离子性盐的感应盐溶液储存部; PCR混合物存储部分，其通过微通道与微室连通并将PCR混合物供应到微室; 以及加热和冷却微室的加热和冷却部分。
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公开(公告)号：KR100276249B1
公开(公告)日：2000-12-15
申请号：KR1019980033176
申请日：1998-08-10
IPC: H01M10/05
CPC classification number: H01M10/052 , H01M10/0565
Abstract: 본 발명은 리튬 폴리머 2차전지용 고분자 전해질 제조방법에 관한 것으로서, 에틸렌 카보네이트(EC:Ethylene Carbonate)/프로필렌 카보네이트(PC: Propylene Carbonate) (50/50 vol %) 용매에 1 몰의 LiClO
4 이 용해된 액체 전해액(70)이 담겨있는 용기(60)내에, 폴리비닐리딘 플루오라이드(Polyvinylidene fluoride) 필름(80)을 상온에서 1시간 동안 함침시킨 후, 필름 표면의 전해액을 제거하여 고분자 전해질을 제조함으로써, 비교적 간단한 공정과 장치만으로 제조가 가능하며, 별도의 용매를 사용하지 않으므로 용매의 건조와 같은 공정이 필요치 않아 보다 짧은 시간내에 제조가 가능한 것은 물론, 비용이 적게 들고 공해 문제를 발생시키지 않아 환경친화적인 매우 유용한 발명이다.Abstract translation: 目的：提供高聚合物电解质形成方法简单且成本低廉。 构成：用于形成二次锂聚合物电池的高分子电解质的方法包括以下步骤：通过使用极性大的偶极矩的高分子材料制备高分子膜; 并且在预定时间内将高分子膜浸渍在与高分子膜具有大亲合力的锂苏打中制成高分子电解质，其中在步骤1中将电解质在30℃至60℃的范围内加热 制成高分子电解质。
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公开(公告)号：KR102257370B1
公开(公告)日：2021-05-31
申请号：KR1020200133131
申请日：2020-10-15
Applicant: 삼성전자주식회사
IPC: G09G5/22
Abstract: 외부로보여지는크기가일정한제1 부분및 상기외부로보여지는크기가변화하는제2 부분을포함하는디스플레이, 상기디스플레이를제어하는디스플레이드라이버 IC, 상기디스플레이의열화를보상하는열화보상알고리즘을저장하는메모리, 및상기디스플레이드라이버 IC 및상기메모리와작동적으로연결된프로세서를포함하고, 상기프로세서는, 상기제1 부분및 상기제2 부분을구분하는제1 경계및 상기제2 부분을복수의가상영역들로구분하는제2 경계를설정하고, 상기복수의가상영역들은서로인접한제1 영역및 제2 영역을포함하는, 상기복수의가상영역들각각의누적사용시간및 복수의가상영역들각각의구동과관련된적어도하나의특성값에기반하여상기복수의영역들각각의종합누적값들을산출하고, 상기제1 영역의종합누적값인제1 종합누적값 및상기제2 영역의종합누적값인제2 종합누적값의차이값이지정된임계값 이상인경우, 상기제2 경계중 상기제1 영역및 상기제2 영역사이의경계를열화경계로설정하고, 및상기열화경계를포함하는열화데이터를상기디스플레이드라이버 IC로전달하도록설정된전자장치가개시된다. 이외에도명세서를통해파악되는다양한실시예가가능하다.
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Patent Agency Ranking
公开(公告)号：KR101288969B1
公开(公告)日：2013-07-24
申请号：KR1020060031491
申请日：2006-04-06
Applicant: 삼성전자주식회사
CPC classification number: B04B5/02 , B04B13/00 , G01N15/042 , G01N15/05 , G01N21/07 , G01N33/491
Abstract: 본 발명은 제1 회전축에 수직한 방향의 제2 회전축을 중심으로 회전하는 회전 드럼을 구비하고, 상기 회전 드럼은 시료를 주입하기 위한 주입구, 상기 시료를 표면에 수용하고 상기 제2 회전축으로부터 상기 회전 드럼의 내부 표면 방향으로 방사상으로 연장되는 하나 이상의 회전판 및 분리된 시료를 배출하기 위한 배출구를 포함하고, 상기 회전판은 그 표면에 돌출부 및 오목부로 이루어진 군으로부터 선택되는 한 종류 이상의 구조를 가진 것인, 물질을 무게뿐만 아니라 크기에 따라 분리하기 위한 원심분리기 및 그를 이용하여 물질을 분리하는 방법을 제공한다.
원심분리기, 회전판, 볼록부, 오목부-
公开(公告)号：KR100862660B1
公开(公告)日：2008-10-10
申请号：KR1020060092921
申请日：2006-09-25
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
Abstract: 본 발명은 세포 또는 바이러스 함유 시료를 결합 완충액에 분산된 비드 용액과 혼합하여 세포 또는 바이러스를 비드에 결합시키는 단계; 세포 또는 바이러스가 결합된 상기 비드를 분리하여 완충액으로 세정하는 단계; 상기 비드에 결합된 세포 또는 바이러스를 파괴하여, 상기 세포 또는 바이러스에서 방출된 핵산을 상기 비드에 결합시키는 단계; 상기 핵산이 결합된 비드를 완충액으로 세정하는 단계; 및 상기 비드에 핵산 용출 완충액을 첨가하여 비드에 결합된 핵산을 용출하는 단계를 포함하며, 상기 비드의 표면은 화학식 I의 물질이 결합된 것을 특징으로 하는 세포 또는 바이러스로부터 핵산을 분리 및 정제하는 방법을 제공한다.
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公开(公告)号：KR100790888B1
公开(公告)日：2008-01-02
申请号：KR1020060093681
申请日：2006-09-26
Applicant: 삼성전자주식회사
IPC: A61M5/14
CPC classification number: B01L9/527 , B01L3/5021 , B01L3/5027 , B01L2200/027 , B01L2300/0832 , B01L2400/0409 , C12M23/16
Abstract: A centrifugal force-based fluid loading device with a simple structure is provided to load a fluidic sample to a microfluidic chip at a proper drive pressure using a centrifugal force. A centrifugal force-based fluid loading device includes: a fluid storage part(21) to store a fluidic sample to be loaded into a microfluidic chip(10); a loading part(20) having a chip receiving part to accommodate a part of the microfluidic chip, such as a portion including an injection port(14); and a support part(30) having a support formed in a manner to support the other part of the microfluidic chip. The chip receiving part has an exit(24) of the fluid storage part. The microfluidic chip has an outlet(15) on the opposite side of the injection port to make a fluid flow from the injection port to the outlet, and the support part has a discharged fluid storage(31) to keep the discharged fluid from the outlet.
Abstract translation: 提供具有简单结构的基于离心力的流体加载装置，以使用离心力将流体样品以合适的驱动压力加载到微流体芯片。 基于离心力的流体加载装置包括：流体存储部分（21），用于存储待加载到微流体芯片（10）中的流体样品; 具有用于容纳微流体芯片的一部分的芯片接收部分的装载部分（20），诸如包括注射端口（14）的部分; 以及具有以支撑微流体芯片的另一部分的方式形成的支撑件的支撑部分（30）。 芯片接收部分具有流体存储部分的出口（24）。 微流体芯片在注入口的相对侧上具有出口（15），以使得流体从注入口流到出口，并且支撑部分具有排出的流体储存器（31），以将排出的流体从出口 。
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公开(公告)号：KR1020080027607A
公开(公告)日：2008-03-28
申请号：KR1020060092921
申请日：2006-09-25
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00 , C12Q1/6806 , B01J20/32 , B01J20/3242 , B01J20/328
Abstract: A method and an apparatus for isolating and purifying nucleic acids are provided to isolate cells or viruses using a single bead where a material having a hydrophobic moiety for isolating the cells and a pH dependent charge switching moiety for purifying the nucleic acids are and purify the nucleic acids is coupled and isolate and purify the nucleic acids from the isolated cells or viruses efficiently. A method for isolating nucleic acids from cells or viruses and purifying comprises the steps of: (a) mixing a sample containing the cells or viruses with a bead solution dispersed in a binding buffer solution to couple the cells or viruses to the bead; (b) after isolating the cells or viruses coupled to the bead, washing them with a buffer solution; (c) lysing the cells or viruses coupled to the bead to couple the nucleic acids released from the cells or viruses to couple them to the bead; (d) washing the nucleic acid coupled bead with a buffer solution; and (e) adding a nucleic acid elution buffer solution to the bead to elute the nucleic acid coupled to the bead, wherein the surface of the bead is coupled to a compound represented by the formula(1). In the formula(1), Z1 is carboxyl or amino; each R1, R2, R3, R5, R6, R7, R8, R9, and R11 may be same or different, and is independently H, halogen, hydroxy, C1-20 alkyl, C1-20 alkoxy, C2-20 alkenyl, C6-30 aryl, or C6-30 aryloxy; R4 is C4-20 alkyl, C4-20 alkoxy, C4-20 alkenyl, C6-30 aryl, or C6-30 aryloxy; R10 is C3-30 heteroaryl or heterocyclic including nitrogen atom; each j, k, l and m is independently an integer from 1 to 10; and n is an integer from 1 to 30,000. An apparatus for isolating and purifying nucleic acids continuously comprises: a cell or virus lysing microchamber where a sample inlet is formed to receive a sample; a bead dispersion storage portion which is communicated with the microchamber through a microchannel and supplies the bead dispersion to the microchamber; a binding buffer storage portion which is communicated with the microchamber through the microchannel and supplies a binding buffer to the microchamber; a nucleic acid elution buffer storage portion which is communicated with the microchamber through the microchannel and supplies a nucleic acid elution buffer to the microchamber; and a laser generation portion which is adhered to the microchamber to supply laser. Further, a step of lysing the cells or viruses is performed by heating or emitting laser.
Abstract translation: 提供用于分离和纯化核酸的方法和装置，以使用单个珠来分离细胞或病毒，其中具有用于分离细胞的疏水部分的材料和用于纯化核酸的pH依赖性电荷转换部分是纯化核酸 酸被偶联，并且有效分离和纯化来自分离的细胞或病毒的核酸。 用于从细胞或病毒中分离核酸和纯化的方法包括以下步骤：（a）将含有细胞或病毒的样品与分散在结合缓冲溶液中的珠粒溶液混合以将细胞或病毒偶联到珠粒上; （b）在分离与珠子偶联的细胞或病毒之后，用缓冲溶液洗涤; （c）裂解与珠粒偶联的细胞或病毒以将从细胞或病毒释放的核酸偶联以将其偶联到珠粒上; （d）用缓冲溶液洗涤核酸偶联的珠粒; 和（e）向珠粒中加入核酸洗脱缓冲溶液以洗脱与珠粒偶联的核酸，其中珠粒表面与由式（1）表示的化合物偶联。 在式（1）中，Z 1为羧基或氨基; 每个R 1，R 2，R 3，R 5，R 6，R 7，R 8，R 9和R 11可以相同或不同，并且独立地是H，卤素，羟基，C 1-20烷基，C 1-20烷氧基，C 2-20烯基， -30芳基或C6-30芳氧基; R4是C4-20烷基，C4-20烷氧基，C4-20烯基，C6-30芳基或C6-30芳氧基; R10是C3-30杂芳基或杂环，包括氮原子; 每个j，k，l和m独立地是1至10的整数; n为1〜30,000的整数。 用于连续分离和纯化核酸的装置包括：细胞或病毒裂解小室，其中形成样品入口以接收样品; 珠分散储存部分，其通过微通道与微室相连，并将珠分散体供应到微室; 结合缓冲存储部分，其通过微通道与微型仓相连，并向微型仓提供结合缓冲液; 核酸洗脱缓冲液存储部分，其通过所述微通道与所述微型仓相连，并将核酸洗脱缓冲液提供给所述微型仓; 以及激光产生部分，其粘附到微型仓以提供激光。 此外，通过加热或发射激光来进行裂解细胞或病毒的步骤。
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公开(公告)号：KR100785010B1
公开(公告)日：2007-12-11
申请号：KR1020060031490
申请日：2006-04-06
Applicant: 삼성전자주식회사
CPC classification number: C12N15/1006 , C12N15/1003
Abstract: A method and a device for purifying a DNA are provided to use a solid support without any surface treatment and bind a nucleic acid without a special additive in a wide pH range, thereby being usefully used for a lab-on-a chip. A method for purifying a DNA comprises a step of binding the DNA to a solid support by contacting a DNA-containing sample and a sample containing a kosmotropic salt selected from the group consisting of SO4^2-, HPO4^2-. OH^-, F^-, HCOO^-, and CH3COO^- on the solid support of which the surface has a hydrophilic functional group. A device for purifying a DNA comprises a kosmotropic salt storage portion which is communicated to the solid support through a microchannel and supplies the kosmotropic salt and the solid support having a hydrophilic functional group on the surface thereof. The device further comprises a DNA elution buffer solution storage portion communicated to the solid support through the microchannel and supplying a DNA elution buffer solution to the solid support. A lab-on-a-chip comprises the DNA purifying device.
Abstract translation: 提供用于纯化DNA的方法和装置以使用固体支持物而不进行任何表面处理，并且在宽的pH范围内结合无特殊添加剂的核酸，从而有用地用于芯片实验室。 用于纯化DNA的方法包括通过使含DNA样品和含有选自SO 4 2-，HPO 4 -2-的选择性差异盐的样品接触来将DNA结合到固体支持物的步骤。 在其表面具有亲水官能团的固体载体上具有OH - ，F - - ，HCOO - - 和CH 3 COO - 。 用于纯化DNA的装置包括通过微通道与固体支持物连通并在其表面上提供具有亲水性官能团的去离子盐和固体支持物的感应盐储存部分。 该装置还包括通过微通道与固体支持物连通的DNA洗脱缓冲溶液储存部分，并将DNA洗脱缓冲溶液供应至固体支持物。 DNA实验室包括DNA纯化装置。
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