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公开(公告)号：KR1020090121625A
公开(公告)日：2009-11-26
申请号：KR1020080047607
申请日：2008-05-22
Applicant: 서강대학교산학협력단
Abstract: PURPOSE: A polypeptide containing Oct-4 binding domain of PKM2(pyruvate kinase type M2) is provided to control cell differentiation by promoting or suppressing Oct-4 transcription. CONSTITUTION: A polypeptide promotes Oct-4 transcription factor activity by binding to the Oct-4. The polypeptide is an Oct-4 binding domain of PKM2 protein comprising amino acid of the sequence number 2. An expression vector for regulating Oct-4 transcription factor activity contains a polynucleotide encoding the polypeptide or anti-sense polynucleotide which is complementary to the polynucleotide.
Abstract translation: 目的：提供含有PKM2（丙酮酸激酶M2型）的Oct-4结合结构域的多肽，以通过促进或抑制Oct-4转录来控制细胞分化。 构成：多肽通过与Oct-4结合而促进Oct-4转录因子活性。 多肽是包含序列号2的氨基酸的PKM2蛋白的Oct-4结合结构域。用于调节Oct-4转录因子活性的表达载体含有编码与多核苷酸互补的多肽或反义多核苷酸的多核苷酸。
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公开(公告)号：KR101226647B1
公开(公告)日：2013-01-25
申请号：KR1020100065564
申请日：2010-07-07
Applicant: 서강대학교산학협력단
IPC: C12N5/02 , C07K14/72 , C12N5/0735
Abstract: 본 발명은 ERR (Estrogen Related Receptor)α를 유효성분으로 포함하는 Oct-4 전사인자의 활성 촉진용 조성물 및 ERRα를 유효성분으로 포함하는 만능성 세포의 분화 조절용 조성물에 관한 것이다. 본 발명의 ERRα 단백질은 전사인자 Oct-4의 활성을 촉진하여 Oct-4가 관여하는 만능성 세포의 분화과정을 조절하는데 이용될 수 있다.
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公开(公告)号：KR1020080111185A
公开(公告)日：2008-12-23
申请号：KR1020070059229
申请日：2007-06-18
Applicant: 서강대학교산학협력단
Abstract: A composition for regulating the transcriptional activity of hTAFII68(NTD) is provided to control the transcriptional activity of the hTAFII 68 (NTD) which is oncogene easily. A polypeptide for regulating the transcriptional activity of hTAFII68(NTD) comprises the hTAFII 68 (NTD) binding domain of the GAPDH protein of the second sequence. The hTAFII 68 (NTD) binding domain of the GAPDH protein of the second sequence promotes the transcriptional activity of the hTAFII 68 (NTD).
Abstract translation: 提供了一种用于调节hTAFII68（NTD）转录活性的组合物，用于控制致癌基因hTAFII 68（NTD）的转录活性。 用于调节hTAFII68（NTD）的转录活性的多肽包含第二序列的GAPDH蛋白的hTAFII 68（NTD）结合结构域。 第二序列的GAPDH蛋白的hTAFII 68（NTD）结合结构域促进hTAFII 68（NTD）的转录活性。
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公开(公告)号：KR101263758B1
公开(公告)日：2013-05-13
申请号：KR1020100102056
申请日：2010-10-19
Applicant: 서강대학교산학협력단
IPC: C12N5/0735 , C12N5/02 , C12N5/071
Abstract: 본발명은유효성분으로서태반추출물을포함하는줄기세포용배지조성물로서, 상기배지조성물은줄기세포의증식을촉진하고, 줄기세포의미분화상태를유지하며, 줄기세포의분화능을유지하는것을특징으로하는줄기세포용배지조성물에관한것이다. 본발명에의해배양된줄기세포특히배아줄기세포는증식속도가증가된다. 본발명에의해배양된줄기세포특히배아줄기세포는줄기세포의고유한특성예를들어미분화상태및 분화능을그대로유지한다. 돼지태반추출물은비교적으로저가로용이하게구입할수 있기때문에, 줄기세포특히배아줄기세포를보다쉽게얻을수 있고배양할수 있는새로운접근방식을제공한다.
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Patent Agency Ranking
公开(公告)号：KR1020120040571A
公开(公告)日：2012-04-27
申请号：KR1020100102056
申请日：2010-10-19
Applicant: 서강대학교산학협력단
IPC: C12N5/0735 , C12N5/02 , C12N5/071
Abstract: PURPOSE: A medium composition containing placental extract for culturing stem cells is provided to enhance proliferation rate of the embryonic stem cells and to maintain undifferentiation state and differentiation ability. CONSTITUTION: A composition for promoting proliferation of stem cells contains placental extract as an active ingredient. The medium composition contains placental extract as an active ingredient. The placental extract is derived from pigs. The stem cells are pluripotent stem cells or multipotent stem cells. A method for maintaining and increasing stem cells comprises a step of culturing the stem cells in a medium containing placental extract.
Abstract translation: 目的：提供含有培养干细胞的胎盘提取物的培养基组合物，以提高胚胎干细胞的增殖率，保持未分化状态和分化能力。 构成：用于促进干细胞增殖的组合物含有胎盘提取物作为活性成分。 培养基组合物含有胎盘提取物作为活性成分。 胎盘提取物来源于猪。 干细胞是多能干细胞或多能干细胞。 维持和增加干细胞的方法包括在含有胎盘提取物的培养基中培养干细胞的步骤。
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公开(公告)号：KR101226650B1
公开(公告)日：2013-01-25
申请号：KR1020100065575
申请日：2010-07-07
Applicant: 서강대학교산학협력단
IPC: C12N5/02 , C07K14/72 , C12N5/0735
Abstract: 본 발명은 ERR (Estrogen Related Receptor)γ를 유효성분으로 포함하는 Oct-4의 전사활성 촉진용 조성물 및 ERRγ를 유효성분으로 포함하는 만능성 세포의 분화 조절용 조성물에 관한 것이다. 본 발명의 ERRγ 단백질은 전사인자 Oct-4의 전사 활성을 촉진하여 Oct-4가 관여하는 만능성 세포의 분화과정을 조절하는데 이용될 수 있다.
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公开(公告)号：KR1020120004860A
公开(公告)日：2012-01-13
申请号：KR1020100065564
申请日：2010-07-07
Applicant: 서강대학교산학협력단
IPC: C12N5/02 , C07K14/72 , C12N5/0735
Abstract: PURPOSE: A composition containing ERRalpha for promoting Oct-4 transcription factor activity is provided to develop pluripotent cell development. CONSTITUTION: A for promoting Oct-4 transcription factor contains ERR(estrogen related receptor) alpha protein and expression constructor thereof. The ERRalpha contains an amino acid of sequence number 1. A composition for controlling differentiation of pluripotent cells contains ERRapha or expression construct thereof as an active ingredient. The pluripotent cells are ES(embryonic stems), CE(embryonic carcinoma) or Eg(embryonic germ).
Abstract translation: 目的：提供含有用于促进Oct-4转录因子活性的ERRalpha的组合物以发展多能细胞发育。 构成：A用于促进Oct-4转录因子含有ERR（雌激素相关受体）α蛋白及其表达构建子。 ERRalpha含有序列号1的氨基酸。用于控制多能细胞分化的组合物含有作为活性成分的ERRapha或其表达构建体。 多能细胞是ES（胚胎干），CE（胚胎癌）或Eg（胚胎胚）。
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公开(公告)号：KR1020090035833A
公开(公告)日：2009-04-13
申请号：KR1020070100839
申请日：2007-10-08
Applicant: 서강대학교산학협력단
IPC: G01N33/574 , G01N33/68 , G01N33/53
Abstract: A method for screening antineoplastic which inhibits transcriptional activity of a WS-Oct-4 fusion protein is provided to screen the antineoplastic in a high-throughput way. A method for screening antineoplastic comprises the following steps of: treating candidate antineoplastic in a host cell transformed by a vector containing EWS-Oct-4 fusion protein coding polynucleotide sequence operately linked to a promoter and a vector containing a reporter gene operately linked to a promoter positively controlled by the EWS-Oct-4 fusion protein; and measuring degree of expression of the reporter gene in the transformed host cell. The EWS-Oct-4 fusion protein has amino acid sequence of SEQ ID NO:1.
Abstract translation: 提供了抑制WS-Oct-4融合蛋白转录活性的抗肿瘤药物的方法，以高通量方式筛选抗肿瘤药物。 筛选抗肿瘤药物的方法包括以下步骤：在宿主细胞中处理候选抗肿瘤药物，所述宿主细胞由含有与启动子操作连接的EWS-Oct-4融合蛋白编码多核苷酸序列的载体转化，和含有与启动子连接的报告基因的载体 由EWS-Oct-4融合蛋白阳性控制; 并测量转化的宿主细胞中报告基因的表达程度。 EWS-Oct-4融合蛋白具有SEQ ID NO：1的氨基酸序列。
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公开(公告)号：KR1020120004867A
公开(公告)日：2012-01-13
申请号：KR1020100065575
申请日：2010-07-07
Applicant: 서강대학교산학협력단
IPC: C12N5/02 , C07K14/72 , C12N5/0735
Abstract: PURPOSE: A composition containing ERRgamma for promoting Oct-4 transcription activity is provided to control differentiation of pluripotent cells. CONSTITUTION: A composition for promoting Oct-4 transcription factor activity contains ERR(estrogen related receptor) gamma protein or expression construct thereof. The ERRgamma protein contains an amino acid sequence of sequence number 1, 2, 3, 4, 5, or 6. A composition for controlling differentiation of pluripotent cells contains the ERRgamma or expression construct thereof as an active ingredient.
Abstract translation: 目的：提供含有用于促进Oct-4转录活性的ERRgamma的组合物，以控制多能细胞的分化。 构成：用于促进Oct-4转录因子活性的组合物含有ERR（雌激素相关受体）γ蛋白或其表达构建体。 ERRγ蛋白质含有序列号1,2,3,4,5或6的氨基酸序列。用于控制多能细胞分化的组合物含有作为活性成分的ERRγ或其表达构建体。
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