公开(公告)号：KR1020120038704A

公开(公告)日：2012-04-24

申请号：KR1020100100302

申请日：2010-10-14

Applicant: 서울대학교산학협력단

Inventor： 문태화 ,  김지형 ,  이창주

IPC: A23L7/104 ,  A23L7/10 ,  A23L19/12

CPC classification number: A23L7/104 ,  A23L19/12 ,  A23V2002/00

Abstract: PURPOSE: A producing method of starch with improved slowly digestibility and indigestibility is provided to improve the degree of polymerization of the starch using the enzyme reaction. CONSTITUTION: A producing method of starch with improved slowly digestibility and indigestibility comprises the following steps: gelatinizing a suspension including starch and sugar; adding neiserria polysaccharea based amylosucrase enzyme liquid into the gelatinized suspension, and inducing the enzyme reaction at 25-35 deg C; and hydrothermal treating the enzyme reacted starch at 80-120 deg C for 20-60 minutes. The starch is selected from glutinous rice starch, non-glutinous rice starch, waxy corn starch, corn starch, glutinous potato starch, or potato starch.

Abstract translation: 目的：提供改善缓慢消化率和消化不良的淀粉的生产方法，以提高使用酶反应的淀粉的聚合度。 构成：具有改善缓慢消化率和消化不良的淀粉的生产方法包括以下步骤：使包含淀粉和糖的悬浮液糊化; 在凝胶化悬浮液中加入基于多糖的淀粉酶基淀粉酶液体，并在25-35℃诱导酶反应; 并将酶反应淀粉在80-120℃水热处理20-60分钟。 淀粉选自糯米淀粉，非糯米淀粉，蜡质玉米淀粉，玉米淀粉，糯米淀粉或马铃薯淀粉。

公开(公告)号：KR101216058B1

公开(公告)日：2012-12-27

申请号：KR1020100100302

申请日：2010-10-14

Applicant: 서울대학교산학협력단

Inventor： 문태화 ,  김지형 ,  이창주

IPC: A23L7/104 ,  A23L7/10 ,  A23L19/12

Abstract: 본발명은 (A) 전분과설탕을포함하는현탁액을호화시킨후, 호화된현탁액에네이세리아폴리사카레아() 유래의아밀로수크라아제(E.C. 2.4.1.4) 효소액을첨가하여 25~35℃에서효소반응을유도하는단계; 및 (B) 상기효소반응된전분을 80~120℃에서 20~60분간수열처리(hydrothermal treatment)하는단계;를포함하는것을지소화성및 난소화성이증진된전분의제조방법을특징으로한다.

公开(公告)号：KR101156103B1

公开(公告)日：2012-06-20

申请号：KR1020110144637

申请日：2011-12-28

Applicant: 서울대학교산학협력단

Inventor： 윤순창 ,  김상우 ,  김지형

IPC: G01N15/14 ,  G01N21/47 ,  G01N21/31 ,  G01N33/00

Abstract: PURPOSE: A yellow dust detecting method using a scattering coefficient and absorption coefficient of an aerosol is provided to enhance the accuracy with respect to a detection of yellow dust by using an aerosol optical property. CONSTITUTION: A yellow dust detecting method using a scattering coefficient and absorption coefficient of an aerosol is as follows. A degree in which an aerosol scatters solar lights is measured by sucking aerosol particles floating in the air through a nephelometer(S10). The degree in which the aerosol scatters solar lights is measured by sucking the aerosol particles floating in the air through a aethalometer(S30). An angstrom coefficient and aerosol single scattering albedo are calculated by using a difference of sizes and each wavelength size of a scattering coefficient and absorption coefficient of the aerosol. Whether yellow dust is generated or not and properties and the intensity of the yellow dust are identified by using the angstrom coefficient and aerosol single scattering albedo and the existing PM10 mass concentration.

Abstract translation: 目的：提供使用气溶胶的散射系数和吸收系数的黄色粉尘检测方法，以通过使用气溶胶光学性质来提高对黄色粉尘的检测的准确性。 构成：使用散射系数和气溶胶的吸收系数的黄色粉尘检测方法如下。 气雾剂散射太阳光的程度是通过吸附浮标在空气中的气溶胶颗粒来测量的（S10）。 气溶胶散射太阳光的程度是通过吸入通过一个水平计漂浮在空气中的气溶胶颗粒来测量的（S30）。 通过使用散射系数的大小和每个波长尺寸和气溶胶的吸收系数的差异来计算埃和系数和气溶胶单散射反照率。 是否产生黄色粉尘，通过使用埃斯特系数和气溶胶单散射反照率和现有的PM10质量浓度来确定黄色粉尘的性质和强度。

公开(公告)号：KR1020130107000A

公开(公告)日：2013-10-01

申请号：KR1020120028748

申请日：2012-03-21

Applicant: 서울대학교산학협력단

Inventor： 정두현 ,  오새진 ,  김지형

IPC: A61K48/00 ,  G01N33/15 ,  G01N33/68 ,  A61K31/7088

CPC classification number: C12Q1/485 ,  A61K31/4439 ,  C12Q1/68 ,  G01N33/74 ,  G01N2500/02 ,  G01N2800/26

Abstract: PURPOSE: A sepsis therapeutic agent acquired through a method for screening a sepsis therapeutic agent which targets NOD2 signal transduction pathway is provided to effective treat sepsis. CONSTITUTION: A method for screening a sepsis therapeutic agent comprises the steps of: providing RIP2 (RICK) protein; making RIP2 and a test material which is expected to suppress phosphorylation or kinase activity come in contact; and selecting a material which reduces phosphorylation or kinase activity of RIP2 compared with a control group. A pharmaceutical composition for treating sepsis contains an inhibitor which suppresses kinase activation or phosphorylation of RIP2.

Abstract translation: 目的：提供一种通过筛选靶向NOD2信号转导途径的败血症治疗剂的方法获得的败血症治疗剂，用于有效治疗败血症。 构成：筛选败血症治疗剂的方法包括以下步骤：提供RIP2（RICK）蛋白; 使RIP2和预期抑制磷酸化或激酶活性的测试材料接触; 并选择与对照组相比降低RIP2的磷酸化或激酶活性的材料。 用于治疗败血症的药物组合物含有抑制RIP2的激酶活化或磷酸化的抑制剂。

公开(公告)号：KR101497972B1

公开(公告)日：2015-03-03

申请号：KR1020120028748

申请日：2012-03-21

Applicant: 서울대학교산학협력단

Inventor： 정두현 ,  오새진 ,  김지형

IPC: A61K48/00 ,  G01N33/15 ,  G01N33/68 ,  A61K31/7088

CPC classification number: C12Q1/485 ,  A61K31/4439 ,  C12Q1/68 ,  G01N33/74 ,  G01N2500/02 ,  G01N2800/26

Abstract: 본원은 NOD2 매게된 IL-1 베타 의존적 IL-10 생성에 의한 Ly6-G
+ 과립구에서 CD55 발현의 억제를 통한 C5a 상승이 패혈증과 관련이 있다는 발견을 기초로 한 것으로, NOD2 신호전달 경로는 패혈증 치료제 발굴의 효과적인 표적으로 작용할 수 있다. 이러한 관점에서 본원은 NOD2 신호전달 경로의 차단을 통해 패혈증을 효과적으로 치료할 수 있는 물질의 스크리닝 방법 및 NOD2 신호전달 경로의 차단 또는 억제제를 포함하는 패혈증 치료용 조성물을 제공한다.