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公开(公告)号：KR1020110131821A
公开(公告)日：2011-12-07
申请号：KR1020100051458
申请日：2010-05-31
Applicant: 서울대학교산학협력단
CPC classification number: A61K36/78 , A23V2200/322 , A23V2200/326 , A23V2200/3262 , A23V2200/328 , A61K2236/33 , A61K2236/39 , Y10S514/824 , Y10S514/866 , Y10S514/909
Abstract: PURPOSE: A composition containing Saururus chinensis BAILL. or sauchinone is provided to suppress glycosylation and to reduce blood glucose and body weight. CONSTITUTION: A pharmaceutical composition for preventing or treating insulin resistance, insulin resistance-associated disease or insulin resistance syndrome contains 0.01-99.9 % of sauchinone or Saururus chinensis BAILL. extract fraction as an active ingredient. A method for preparing the Saururus chinensis BAILL. extract fraction comprises: a step of extracting Saururus chinensis BAILL. with non-polar solvent and removing the non-polar ingredients; a step of isolating with a less polar solvent; and a step of fractioning using n-hexane-ethyl acetate. The composition is manufactured in the form of powder, granule, tablet, capsule, suspension, emulsion, syrup, suppository, and sterilized injection solution.
Abstract translation: 目的：含有Saururus chinensis BAILL的组合物。 或提供橙酮以抑制糖基化并降低血糖和体重。 构成：用于预防或治疗胰岛素抵抗，胰岛素抵抗相关疾病或胰岛素抵抗综合症的药物组合物含有0.01-99.9％的sauchinone或Saururus chinensis BAILL。 提取物级分作为活性成分。 一种制备Saururus chinensis BAILL的方法。 提取物组分包括：提取中华白菜BAILL的步骤。 用非极性溶剂除去非极性成分; 用极性较小的溶剂分离的步骤; 和使用正己烷 - 乙酸乙酯分馏的步骤。 该组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，栓剂和灭菌注射液的形式制备。
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公开(公告)号：KR101711072B1
公开(公告)日：2017-03-09
申请号：KR1020150096078
申请日：2015-07-06
Applicant: 서울대학교산학협력단 , 숙명여자대학교산학협력단
IPC: A61K31/353 , A61K31/405 , A61K31/505 , A23L1/30
Abstract: 본원은 Fyn 키나제저해제를포함하는지방간증및 지방간염을포함한대사성질환의예방또는치료용약학조성물을제공한다. 본원조성물의투여는대사장애에의한지방간증으로인한간조직내 중성지방의축적을억제하고, 지질생성효소유전자발현을조절하는핵심전사인자인 Fyn 키나제및 SREBP-1의발현및 활성을억제함으로써지질생성유전자의발현을억제한다. 따라서 Fyn 키나제저해제를포함하는본원의약학조성물은지방간증및 지방간염을포함한대사성질환을예방하고치료하는데유용하게이용될수 있다.
Abstract translation: 本发明提供用于预防或治疗包括脂肪肝和脂肪肝在内的代谢疾病的药物组合物，包括Fyn激酶抑制剂。 脂质通过给予本发明组合物，以抑制在肝脏中甘油三酯的积累由于局部证明由代谢性疾病，以及抑制SREBP-1的关键转录因子的Fyn激酶和表达和活性，以调节形成酶的基因表达的脂质 并抑制生产基因的表达。 因此，含有Fyn激酶抑制剂的本发明的药物组合物可以有效地用于预防和治疗包括降脂和脂质肝炎的代谢疾病。
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Patent Agency Ranking
公开(公告)号：KR101526621B1
公开(公告)日：2015-06-10
申请号：KR1020100062799
申请日：2010-06-30
Applicant: 현대자동차주식회사 , 서울대학교산학협력단
Abstract: 본발명은안전을위한지능형차량제어방법에관한것으로서, 특히차량에장착된센서를통해주행중인차량및 주변차량의동작상태에따른변화를감지하는차량상태측정단계와; 상기차량상태측정단계를통해차량의상태정보를제공받아바퀴에가해지는힘, 차량의횡속도, 노면마찰계수를데이터로변환하는데이터추정단계와; 상기데이터추정단계를통해차량의종방향제어및 횡방향제어상황을판단하여제어모드를결정하는상황판단단계와; 상기상황판단단계를통해종방향제어시 목표가속도를계산하게되며, 횡방향제어시 목표요율(yaw rate)을계산하는종횡방향제1계산단계와; 상기종횡방향제1계산단계에서계산된목표가속도와목표요율을추종하기위한종방향힘과요모멘트를계산하는종횡방향제2계산단계와; 상기종횡방향제2계산단계에서계산된종방향힘과요모멘트를주행중인차량에적용하여액츄에이터를작동시키는입력값을계산하는종횡방향제3계산단계로이루어져, 기존에독립적으로작동했던차량능동안전시스템인 ESC와 AFS, 운전자보조시스템인 SCC/CA를통합하여제어전략과주행상황별제어모드를정의하고상기제어모드의변경시점을결정할수 있는주행상황판단용데이터를산출할수 있게함으로써, 종래의종방향및 횡방향위험상황뿐만아니라종방향과횡방향의복합적인제어입력이필요한위험상황에서도차량의안정성을높이고원하지않는제어입력을줄여운전자의이질감을최소화하는동시에원활한교통흐름에도움이될 수있게하여상품성을향상시키는데효과가있도록하는것이다.
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公开(公告)号：KR1020120002091A
公开(公告)日：2012-01-05
申请号：KR1020100062801
申请日：2010-06-30
Applicant: 현대자동차주식회사 , 서울대학교산학협력단
Abstract: PURPOSE: An integrated vehicle controlling system for securing the longitudinal and horizontal stability is provided to integrate systems operating separately, and to minimize the unnecessary control input. CONSTITUTION: An integrated vehicle controlling system comprises the following: a parameter measuring unit(100) measuring plural specific parameters; a sensor unit(200) detecting the change of condition based on the operation state of moving vehicles; an estimating unit(300) calculating data of the vehicles based on information obtained from the sensor unit; and a controller(400) controlling an actuator(410) mounted on the vehicle by calculating the target speed reduction rate and the target moment, and by measuring the data of the vehicles.
Abstract translation: 目的：提供一种用于确保纵向和横向稳定性的集成车辆控制系统，以集成单独运行的系统，并最大限度地减少不必要的控制输入。 构成：集成车辆控制系统包括：测量多个特定参数的参数测量单元（100）; 传感器单元，根据移动车辆的运行状态来检测状态的变化; 估计单元，基于从所述传感器单元获得的信息来计算所述车辆的数据; 以及通过计算目标速度降低率和目标力矩以及通过测量车辆的数据来控制安装在车辆上的致动器（410）的控制器（400）。
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公开(公告)号：KR1020120002089A
公开(公告)日：2012-01-05
申请号：KR1020100062799
申请日：2010-06-30
Applicant: 현대자동차주식회사 , 서울대학교산학협력단
Abstract: PURPOSE: An integrated type vehicle controlling method for securing the longitudinal direction stability is provided to improve the stability of vehicles at the dangerous situation. CONSTITUTION: An integrated type vehicle controlling method comprises the following steps: detecting the change on the operation state of driving vehicles using sensors, and measuring a specific parameter of the vehicles(S10); converting power applied on wheels, the horizontal speed of the vehicles, and the load friction coefficient into data(S20); setting a controlling mode by determining the longitudinal and horizontal controlling condition based on the data obtained from the previous step(S30); firstly calculating the longitudinal direction target acceleration speed for obtaining the target rate for horizontal controlling(S40); secondly calculating the longitudinal direction powder and the target moment to obtain the target acceleration speed and the target moment(S50); and thirdly calculating the input value for operating an actuator based on the longitudinal direction powder and the target moment(S60).
Abstract translation: 目的：提供一种确保纵向稳定性的综合型车辆控制方法，以提高车辆在危险情况下的稳定性。 一种综合型车辆控制方法，包括以下步骤：使用传感器检测驾驶车辆的运行状态的变化，并测量车辆的特定参数（S10）; 将车轮上施加的功率，车辆的水平速度和负载摩擦系数转换为数据（S20）; 通过基于从前一步骤获得的数据确定纵向和水平控制条件来设置控制模式（S30）; 首先计算用于获得水平控制的目标速率的纵向目标加速度（S40）; 二次计算纵向粉末和目标力矩以获得目标加速度和目标力矩（S50）; 以及第三计算基于纵向方向粉末和目标力矩来操作致动器的输入值（S60）。
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公开(公告)号：KR1020170005684A
公开(公告)日：2017-01-16
申请号：KR1020150096078
申请日：2015-07-06
Applicant: 서울대학교산학협력단 , 숙명여자대학교산학협력단
IPC: A61K31/353 , A61K31/405 , A61K31/505 , A23L1/30
Abstract: 본원은 Fyn 키나제저해제를포함하는지방간증및 지방간염을포함한대사성질환의예방또는치료용약학조성물을제공한다. 본원조성물의투여는대사장애에의한지방간증으로인한간조직내 중성지방의축적을억제하고, 지질생성효소유전자발현을조절하는핵심전사인자인 Fyn 키나제및 SREBP-1의발현및 활성을억제함으로써지질생성유전자의발현을억제한다. 따라서 Fyn 키나제저해제를포함하는본원의약학조성물은지방간증및 지방간염을포함한대사성질환을예방하고치료하는데유용하게이용될수 있다.
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公开(公告)号：KR101269208B1
公开(公告)日：2013-05-30
申请号：KR1020100051458
申请日：2010-05-31
Applicant: 서울대학교산학협력단
Abstract: 본발명은사우치논또는사우치논이풍부한삼백초추출분획물을유효성분으로포함하는조성물에관한것으로, 본발명의조성물은인슐린저항성을개선하여간세포에서당생성을억제하고근육세포및 지방세포의당이용율을높이며, 혈당감소및 체중감소효과가있어, 인슐린저항성, 인슐린저항성관련질병, 인슐린저항성증후군의예방, 개선또는치료용조성물및 이를포함하는의약또는건강기능식품으로유용하게이용할수 있다.
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