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公开(公告)号：KR1020120056939A
公开(公告)日：2012-06-05
申请号：KR1020100117045
申请日：2010-11-23
Applicant: 한양대학교 산학협력단 , 서울대학교산학협력단
IPC: G01N33/574 , G01N33/15 , G01N33/532
Abstract: PURPOSE: A biomarker composition for diagnosing HER2 inhibitor resistance is provided to develop novel anticancer drugs. CONSTITUTION: A biomarker composition for diagnosing anticancer drug resistance contains ECM(extracellular matrix). The anticancer drug is a HER2 inhibitor, heceptin. The ECM contains an amino acid sequence of sequence number 1. A method for determining the expression of HER2 inhibitor resistance comprises a step of comparing ECM expression level between a control group with a cancer tissue in which HER2 inhibitor is administered. A method for suppressing HER2 inhibitor resistance comprises a step of treating ECM expression inhibitor to HER2 inhibitor-administered cancer cells.
Abstract translation: 目的：提供用于诊断HER2抑制剂抗性的生物标志物组合物，用于开发新型抗癌药物。 构成：用于诊断抗癌药物抗性的生物标志物组合物含有ECM（细胞外基质）。 抗癌药是HER2抑制剂，heceptin。 ECM含有序列号1的氨基酸序列。确定HER2抑制剂抗性表达的方法包括比较对照组与施用HER2抑制剂的癌组织之间的ECM表达水平的步骤。 抑制HER2抑制剂抗性的方法包括对施用HER2抑制剂的癌细胞处理ECM表达抑制剂的步骤。
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公开(公告)号：KR101875935B1
公开(公告)日：2018-07-09
申请号：KR1020100117045
申请日：2010-11-23
Applicant: 한양대학교 산학협력단 , 서울대학교산학협력단
IPC: G01N33/574 , G01N33/15 , G01N33/532
Abstract: 본발명은항암제중 HER2(human epidermal growth factor receptor 2) 타겟치료제, 즉 HER2 저해제를사용한경우, 상기 HER2 저해제에대한감수성이감소하는현상과 ECM(Extracellular Matrix)의발현이증가하는현상의관계를이용하여, HER2 저해제에대한내성이생겼는지여부를결정하는결정수단으로서 ECM(Extracellular Matrix)의발현정도를마커로사용하는방법및 이의용도에관한것이다. 이와같은 ECM(Extracellular Matrix) 발현여부를결정하여 HER2 저해제, 예를들어허셉틴(Herceptin, trastuzumab) 내성여부를판단함으로써적절한대체항암제를사용할수 있게하고, 또한 HER2 저해제에대한내성을극복할수 있는새로운항암제개발에유용하다.
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公开(公告)号：KR101345634B1
公开(公告)日：2013-12-27
申请号：KR1020130015094
申请日：2013-02-13
Applicant: 서울대학교산학협력단
CPC classification number: A61F2/06 , A61F2230/0091 , A61L17/10 , A61L27/04 , A61L27/14
Abstract: The present invention relates to an embolic polymer-metal composite fiber and a preparation method thereof which uses first and second polymer hydrogel films with different expansion rates in the blood formed in a double layer structure by containing crosslinking agents in different contents. A linear form polymer fiber bends inside the blood and is formed into a coil for blocking blood vessels. By varying the concentration of the crosslinking agents and the thickness of the polymer fiber, the coil in a desired shape and size is designed beforehand. [Reference numerals] (AA) First polymer hydrogel film;(BB) Second polymer hydrogel film
Abstract translation: 本发明涉及一种栓塞型聚合物 - 金属复合纤维及其制备方法，其通过含有不同含量的交联剂，使用在双层结构中形成的血液中具有不同膨胀率的第一和第二聚合物水凝胶膜。 线性聚合物纤维在血液内部弯曲并形成用于阻断血管的线圈。 通过改变交联剂的浓度和聚合物纤维的厚度，预先设计所需形状和尺寸的线圈。 （附图标记）（AA）第一聚合物水凝胶膜;（BB）第二聚合物水凝胶膜
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公开(公告)号：KR101304224B1
公开(公告)日：2013-09-05
申请号：KR1020120021370
申请日：2012-02-29
Applicant: 서울대학교산학협력단
CPC classification number: A61L31/04 , A61B17/11 , A61B2017/1107 , A61L31/048 , A61L33/00
Abstract: PURPOSE: An angiostenosis polymer film and a method for manufacturing the same are provided to close blood vessels and to design the polymer film with coils of desired shapes and sizes. CONSTITUTION: A method for manufacturing an angiostenosis polymer film comprises the following steps: dissolving polymers in distilled water; adding cross-linking agents in different ratios after dividing the dissolved polymer solution into a first polymer solution and a second polymer solution; manufacturing a mixture of first and second polymer hydrogel films by adding a catalyst to the first and second polymer solutions; manufacturing first and second polymer hydrogel films by applying the mixture of first and second polymer hydrogel films on a plate and drying the mixture at room temperature; and adhering the first polymer hydrogel film to the second polymer hydrogel film by applying the mixture of first and second polymer hydrogel films between the dried first and second polymer hydrogel films. [Reference numerals] (AA) First polymer hydrogel film; (BB) Second polymer hydrogel film
Abstract translation: 目的：提供血管狭窄聚合物膜及其制造方法以闭合血管并设计具有所需形状和尺寸的线圈的聚合物膜。 构成：用于制造血管狭窄聚合物膜的方法包括以下步骤：将聚合物溶解在蒸馏水中; 在将溶解的聚合物溶液分成第一聚合物溶液和第二聚合物溶液之后，加入不同比例的交联剂; 通过向第一和第二聚合物溶液中加入催化剂制备第一和第二聚合物水凝胶膜的混合物; 通过将第一和第二聚合物水凝胶膜的混合物施加在平板上并在室温下干燥该混合物来制造第一和第二聚合物水凝胶膜; 以及通过将第一和第二聚合物水凝胶膜的混合物施加在干燥的第一和第二聚合物水凝胶膜之间，将第一聚合物水凝胶膜粘附到第二聚合物水凝胶膜。 （附图标记）（AA）第一聚合物水凝胶膜; （BB）第二聚合物水凝胶膜
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