公开(公告)号：KR101345634B1

公开(公告)日：2013-12-27

申请号：KR1020130015094

申请日：2013-02-13

Applicant: 서울대학교산학협력단

Inventor： 한문희 ,  조재영 ,  최승홍 ,  정승채 ,  조혜림 ,  이태훈 ,  김태양 ,  이계한 ,  정우원 ,  신우현

IPC: A61F2/06 ,  A61L27/14 ,  A61L17/10

CPC classification number: A61F2/06 ,  A61F2230/0091 ,  A61L17/10 ,  A61L27/04 ,  A61L27/14

Abstract: The present invention relates to an embolic polymer-metal composite fiber and a preparation method thereof which uses first and second polymer hydrogel films with different expansion rates in the blood formed in a double layer structure by containing crosslinking agents in different contents. A linear form polymer fiber bends inside the blood and is formed into a coil for blocking blood vessels. By varying the concentration of the crosslinking agents and the thickness of the polymer fiber, the coil in a desired shape and size is designed beforehand. [Reference numerals] (AA) First polymer hydrogel film;(BB) Second polymer hydrogel film

Abstract translation: 本发明涉及一种栓塞型聚合物 - 金属复合纤维及其制备方法，其通过含有不同含量的交联剂，使用在双层结构中形成的血液中具有不同膨胀率的第一和第二聚合物水凝胶膜。 线性聚合物纤维在血液内部弯曲并形成用于阻断血管的线圈。 通过改变交联剂的浓度和聚合物纤维的厚度，预先设计所需形状和尺寸的线圈。 （附图标记）（AA）第一聚合物水凝胶膜;（BB）第二聚合物水凝胶膜

公开(公告)号：KR101304224B1

公开(公告)日：2013-09-05

申请号：KR1020120021370

申请日：2012-02-29

Applicant: 서울대학교산학협력단

Inventor： 한문희 ,  조재영 ,  최승홍 ,  이신우 ,  이태훈 ,  김태양 ,  정승채 ,  조혜림 ,  이계한 ,  정우원 ,  오진선

IPC: A61L31/04 ,  A61L33/00 ,  A61B17/11

CPC classification number: A61L31/04 ,  A61B17/11 ,  A61B2017/1107 ,  A61L31/048 ,  A61L33/00

Abstract: PURPOSE: An angiostenosis polymer film and a method for manufacturing the same are provided to close blood vessels and to design the polymer film with coils of desired shapes and sizes. CONSTITUTION: A method for manufacturing an angiostenosis polymer film comprises the following steps: dissolving polymers in distilled water; adding cross-linking agents in different ratios after dividing the dissolved polymer solution into a first polymer solution and a second polymer solution; manufacturing a mixture of first and second polymer hydrogel films by adding a catalyst to the first and second polymer solutions; manufacturing first and second polymer hydrogel films by applying the mixture of first and second polymer hydrogel films on a plate and drying the mixture at room temperature; and adhering the first polymer hydrogel film to the second polymer hydrogel film by applying the mixture of first and second polymer hydrogel films between the dried first and second polymer hydrogel films. [Reference numerals] (AA) First polymer hydrogel film; (BB) Second polymer hydrogel film

Abstract translation: 目的：提供血管狭窄聚合物膜及其制造方法以闭合血管并设计具有所需形状和尺寸的线圈的聚合物膜。 构成：用于制造血管狭窄聚合物膜的方法包括以下步骤：将聚合物溶解在蒸馏水中; 在将溶解的聚合物溶液分成第一聚合物溶液和第二聚合物溶液之后，加入不同比例的交联剂; 通过向第一和第二聚合物溶液中加入催化剂制备第一和第二聚合物水凝胶膜的混合物; 通过将第一和第二聚合物水凝胶膜的混合物施加在平板上并在室温下干燥该混合物来制造第一和第二聚合物水凝胶膜; 以及通过将第一和第二聚合物水凝胶膜的混合物施加在干燥的第一和第二聚合物水凝胶膜之间，将第一聚合物水凝胶膜粘附到第二聚合物水凝胶膜。 （附图标记）（AA）第一聚合物水凝胶膜; （BB）第二聚合物水凝胶膜