Abstract:
본 발명은 플라즈마 처리시 대상물체에 발생할 수 있는 손상을 방지하는 저손상 플라즈마 처리 장치를 개시한다. 본 발명에 따른 플라즈마 처리 장치는 소스 전극과 스테이지 사이에 배치되며, 도전체로 형성되고, 플라즈마 처리 장치에 구비된 진공 챔버와 전기적으로 절연 상태인 제1 그리드를 포함하여 이루어짐으로써, 불순물 입자 또는 너무 높은 에너지를 가진 플라즈마 입자에 의해 대상물체에 발생할 수 있는 손상을 방지한다.
Abstract:
Provided are an exendin-4 derivative linked by hydrophobic bile acid which forms nanoparticles, improves albumin adsorption activity, and increases the in vivo half-life while it shows identical or similar biological activity to natural exendin-4, a method for the preparation thereof and a pharmaceutical composition comprising the same compound so as to be used for treating disease caused by excessive insulin secretion including diabetes, obesity and irritable colon syndrome. The exendin-4 derivative linked by hydrophobic bile acid in which 12th, 27th or 12th and 27th lysine residues are lined to the hydrophobic bile acid is provided. The method for preparing the exendin-4 derivative linked by hydrophobic bile acid comprises the steps of: (1) reacting bile acid with N-hydroxysuccinimide(NHS) to activate the carboxylic acid group of the bile acid; (2) reacting the activated bile acid-NHS with exendin-4; and (3) separating the exendin-4 derivative linked by hydrophobic bile acid from the reaction mixture.