公开(公告)号：KR101075435B1

公开(公告)日：2011-10-24

申请号：KR1020090001655

申请日：2009-01-08

Applicant: 신풍제약주식회사

Inventor： 조일환 ,  이은방 ,  강신철 ,  김원석 ,  이철규

IPC: C07D239/96 ,  A61K31/517 ,  A61P25/28 ,  A61P25/08

CPC classification number: C07D403/12 ,  C07D239/96

Abstract: p는 0 또는 1의정수이다.

公开(公告)号：KR1020090083848A

公开(公告)日：2009-08-04

申请号：KR1020090001655

申请日：2009-01-08

Applicant: 신풍제약주식회사

Inventor： 조일환 ,  이은방 ,  강신철 ,  김원석 ,  이철규

IPC: C07D239/96 ,  A61K31/517 ,  A61P25/28 ,  A61P25/08

CPC classification number: C07D403/12 ,  C07D239/96

Abstract: A novel quinazoline-2,4-dione derivative is provided to have the effects of antioxidation, anticonvulzure, and vasorelaxant and enhance memory and prevent and treat stroke, neurodegenerative disease, Alzheimer disease and epilepsia. A method for manufacturing quinazoline-2,4-dione compound of the chemical formula (I) comprises: a step of reacting a compound of the chemical formula (IV) with amine compound of the chemical formula (V) to obtain a compound of the chemical formula (IX); or a step of reacting a first amine compound of the chemical formula (VI) with compound of the chemical formula (VII) or (VIII) to obtain the compound of the chemical formula (IX); a step of substituting a second amine compound of the chemical formula (IX) with R2, R3 or R2 and R3 to obtain a compound of the chemical formula (Ia); and a step of removing protection group. The compound of the chemical formula (IV) is an ethyl 2-ethoxycarbonylamino benzoate.

Abstract translation: 提供了一种新颖的喹唑啉-2,4-二酮衍生物，具有抗氧化，抗痉挛和血管舒张作用，增强记忆力，预防和治疗中风，神经退行性疾病，阿尔茨海默病和癫痫。 化学式（I）的喹唑啉-2,4-二酮化合物的制造方法包括：使化学式（IV）的化合物与化学式（V）的胺化合物反应的步骤，得到化合物 化学式（IX）; 或使化学式（VI）的第一种胺化合物与化学式（VII）或（VIII）的化合物反应以获得化学式（IX）的化合物的步骤; 用R2，R3或R2和R3取代化学式（IX）的第二种胺化合物以获得化学式（Ia）的化合物的步骤; 并删除保护组的一个步骤。 化学式（IV）的化合物是2-乙氧基羰基氨基苯甲酸乙酯。