公开(公告)号：KR1020010065950A

公开(公告)日：2001-07-11

申请号：KR1019990067521

申请日：1999-12-30

Applicant: 일양약품주식회사

Inventor： 정원태 ,  김승구 ,  이승목 ,  김동연 ,  조길도

IPC: C07D401/14

Abstract: PURPOSE: Provided is a method of separating (-)-enantiomer of the title compound which has better effect of inhibiting excretion of the gastric acid and cell protecting anti-ulcer activity. CONSTITUTION: The title compound is 2-££(4-methoxy-3-methyl)-2-pyridinyl|methylsulfinyl|-5-(1H-pyrrole-1-yl)-1H-benzimidazole represented by the compound (1) from which (-)-enantiomer is separated. The separation process comprises dissolving the racemate in methanol and filtering through membrane filter and separating the enantiomer from the filtrate by column chromatography using Amylose-based solid phase column.

Abstract translation: 目的：提供标题化合物的（ - ） - 对映异构体分离方法，其具有抑制胃酸排泄和细胞保护抗溃疡活性的更好效果。 构成：由化合物（1）表示的标题化合物是2-（4-甲氧基-3-甲基）-2-吡啶基|甲基亚磺酰基| -5-（1H-吡咯-1-基）-1H-苯并咪唑，由 分离出（ - ） - 对映异构体。 分离过程包括将外消旋体溶解在甲醇中并通过膜过滤器过滤并通过使用直链淀粉基固相柱的柱色谱法从滤液中分离对映异构体。