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    신규한 5-피롤릴-2-피리딜메틸설피닐 벤즈이미다졸유도체의 이성질체
    1.
    发明公开
    신규한 5-피롤릴-2-피리딜메틸설피닐 벤즈이미다졸유도체의 이성질체 无效
    5-吡咯基-2-吡啶基甲基苯乙烯苯并咪唑的新成员

    公开(公告)号：KR1020010065950A

    公开(公告)日：2001-07-11

    申请号：KR1019990067521

    申请日：1999-12-30

    Applicant: 일양약품주식회사

    Inventor： 정원태 ,  김승구 ,  이승목 ,  김동연 ,  조길도

    IPC: C07D401/14

    Abstract: PURPOSE: Provided is a method of separating (-)-enantiomer of the title compound which has better effect of inhibiting excretion of the gastric acid and cell protecting anti-ulcer activity. CONSTITUTION: The title compound is 2-££(4-methoxy-3-methyl)-2-pyridinyl|methylsulfinyl|-5-(1H-pyrrole-1-yl)-1H-benzimidazole represented by the compound (1) from which (-)-enantiomer is separated. The separation process comprises dissolving the racemate in methanol and filtering through membrane filter and separating the enantiomer from the filtrate by column chromatography using Amylose-based solid phase column.

    Abstract translation: 目的：提供标题化合物的（ - ） - 对映异构体分离方法，其具有抑制胃酸排泄和细胞保护抗溃疡活性的更好效果。 构成：由化合物（1）表示的标题化合物是2-（4-甲氧基-3-甲基）-2-吡啶基|甲基亚磺酰基| -5-（1H-吡咯-1-基）-1H-苯并咪唑，由 分离出（ - ） - 对映异构体。 分离过程包括将外消旋体溶解在甲醇中并通过膜过滤器过滤并通过使用直链淀粉基固相柱的柱色谱法从滤液中分离对映异构体。

    항산화, 미백, 보습, 면역증강 및 항여드름 작용을 나타내는 목질진흙버섯 자실체 및 배양균사체 추출물, 그 제조방법 및 용도
    3.
    发明公开
    항산화, 미백, 보습, 면역증강 및 항여드름 작용을 나타내는 목질진흙버섯 자실체 및 배양균사체 추출물, 그 제조방법 및 용도 失效
    枸杞子的水果提取物及其制备方法

    公开(公告)号：KR1020000059470A

    公开(公告)日：2000-10-05

    申请号：KR1019990007092

    申请日：1999-03-04

    Applicant: 일양약품주식회사

    Inventor： 이준우 ,  정훈 ,  백성진 ,  김용석 ,  정원태 ,  조길도

    IPC: C12N1/14 ,  C12N1/00

    Abstract: PURPOSE: Extract of Phellinus liteus and a preparing method thereof are provided. The extract has anti-oxidation effect, whitening effect and moisture retentive effect and anti-acne effect and it improves immunity. Therefore, The extract is used for cosmetics and foods. CONSTITUTION: Extracts of Phellinus liteus are obtained by extraction, separation and purification of fruit bodies or hyphae obtained from liquid cultivation. The liquid medium, which is used for cultivating hyphae of Phellinus liteus, comprises 0.1-5% of glucose, 0.05-3% of yeast extract, 0.05-3% of peptone, 0.05% of MgSO4, 0.046% of KH2PO4, 0.01% of CaHPO4, 0.01% of FeCl3.6H2O as trace elements, 0.0072% of MnCl2.4H2O, 0.0025% of CuSO4.5H2O and 0.004% of ZnCl2. The hyphae of Phellinus liteus is cultivated in the liquid medium at 25-35°C for 3-10 days. Then, the hyphae is hot water-extracted by adding purified water thereto, followed by being filtrated and recovered.

    Abstract translation: 目的：提供枸杞提取物及其制备方法。 提取物具有抗氧化作用，美白效果和保湿效果和抗痤疮效果，提高了免疫力。 因此，提取物用于化妆品和食品。 构成：通过提取，分离和纯化从液体培养获得的果实或菌丝获得桑黄提取物。 用于培养枸杞的菌丝的液体培养基包含0.1-5％的葡萄糖，0.05-3％的酵母提取物，0.05-3％的蛋白胨，0.05％的MgSO 4，0.046％的KH 2 PO 4，0.01％的 CaHPO 4，0.01％FeCl 3·6H 2 O作为微量元素，0.0072％MnCl 2·4H 2 O，0.0025％CuSO 4·5H 2 O和0.004％ZnCl 2。 在25-35℃下，在液体培养基中培养桑黄的菌丝3-10天。 然后，通过向其中加入纯水将菌丝热水提取，然后过滤并回收。

    혈액순환 개선에 효과가 있는 동물생약 및 식물생약 조성물
    6.
    发明公开
    혈액순환 개선에 효과가 있는 동물생약 및 식물생약 조성물 无效
    用于血液循环的动物和植物草本组合物

    公开(公告)号：KR1020070070292A

    公开(公告)日：2007-07-04

    申请号：KR1020050032980

    申请日：2005-04-21

    Applicant: 일양약품주식회사

    Inventor： 김동연 ,  정원태 ,  박선 ,  이선애 ,  박미선 ,  김현미

    IPC: A61K35/646 ,  A61K35/62 ,  A61K35/64 ,  A61K36/258 ,  A61K36/65 ,  A61K9/20 ,  A61K9/48

    CPC classification number: A61K35/646 ,  A61K9/20 ,  A61K9/48 ,  A61K35/62 ,  A61K35/63 ,  A61K36/258 ,  A61K36/65

    Abstract: An animal and plant herbal composition for improving blood circulation is provided to promote blood flow, relief blood coagulation and improve blood vessel hardening such as arteriosclerosis without side effects. The animal and plant herbal composition for improving blood circulation comprises animal herb medicines containing 10-18 wt.% of Buthus martensi(scorpion), 15-25 wt.% of Whitmania pigra Whitman, 10-15 wt.% of Cryptotympana pustulata, 5-12 wt.% of Scolopendra subspinipes mutilans and 13-19 wt.% of Eupolyphaga sinensis Walker, and plant herb medicines containing 10-15 wt.% of Panax ginseng, 12-17 wt.% of Paeoniae Radix and 1.8-4 wt.% of Dryobalanops aromatica Gaertner, wherein the composition is formulated as tablet or capsule.

    Abstract translation: 提供用于改善血液循环的动植物草药组合物，以促进血液流动，缓解血液凝固，改善血管硬化，如动脉硬化，无副作用。 用于改善血液循环的动物和植物草药组合物包含含有10-18重量％的马蹄i（蝎子），15-25重量％的惠特马尼亚白猪（Whitmania pigra Whitman），10-15wt。％糠of（Cryptotympana pustulata），5 -12重量％的Scolopendra subspinipes mutilans和13-19重量％的Eupolyphaga sinensis Walker，以及含有10-15重量％人参，12-17重量％芍药和1.8-4重量％ DryBalanops aromatica Gaertner的％，其中组合物配制成片剂或胶囊。

    비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물
    7.
    发明公开
    비페닐디메틸디카복실레이트의 경구용 마이크로에멀젼조성물 无效
    包含二苯甲酰甲氧基甲酸的口服微乳液组合物

    公开(公告)号：KR1020040047056A

    公开(公告)日：2004-06-05

    申请号：KR1020020075126

    申请日：2002-11-29

    Applicant: 한미사이언스 주식회사 ,  일양약품주식회사

    Inventor： 우종수 ,  정원태 ,  김애국 ,  유태숙 ,  김문수 ,  황민식

    IPC: A61K9/107

    CPC classification number: A61K31/015 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4866

    Abstract: PURPOSE: Provided is an oral micro-emulsion composition comprising biphenyldimethyldicarboxylate of which bioavailability is increased. The composition has excellent stability to long term storage not to form a crystal, is spontaneously and easily emulsified in the body fluid to show excellent dissolution. Therefore, its active ingredient is effectively absorbed into the living body by oral administration. CONSTITUTION: An oral micro-emulsion composition is characterized by comprising biphenyldimethyldicarboxylate as active ingredient, and co-surfactant, surfactant and oil as solvent. The weight ratio of biphenyldimethyldicarboxylate to co-surfactant to surfactant to oil is 1:5-300:1-300:1-300.

    Abstract translation: 目的：提供包含其中生物利用度增加的联苯二甲基二羧酸酯的口服微乳液组合物。 该组合物具有优异的长期储存稳定性，不会形成晶体，在体液中自发容易地乳化，显示优异的溶解性。 因此，其活性成分通过口服有效地吸收到生物体内。 构成：口服微乳液组合物的特征在于包含联苯二甲基二羧酸酯作为活性成分，辅助表面活性剂，表面活性剂和油为溶剂。 联苯二甲基二羧酸酯与辅助表面活性剂与油相比的重量比为1:5〜300：1-300：1-300。

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