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公开(公告)号：KR1020100124359A
公开(公告)日：2010-11-29
申请号：KR1020090043313
申请日：2009-05-19
Applicant: 제주대학교 산학협력단
CPC classification number: A61K31/7048 , A61K36/62 , A61K2236/33 , A61K2236/55 , Y10S514/917
Abstract: PURPOSE: A radiation radioprotective composition containing geraniin isolated from Nymphaea tetragona var. angusta extract fraction is provided to promote protection and recovery of hematopoietic system and to suppress oxidative cell damage. CONSTITUTION: A radiation radioprotective composition contains 0.001-10.0 weight% of geraniin as an active ingredient. The geraniin is isolated from Nymphaea tetragona var. angusta extract fraction. A method for isolating geraniin comprises: a step of preparing Nymphaea tetragona var. angusta in a powdery form and suspending with distilled water; a step of fractioning with hexane, ethyl acetoacetate, butanol, and water; a step of fractioning with methylene chloride, diethyl ether, ethyl acetate, and acetone; and a step of isolating geraniin by column chromatography.
Abstract translation: 目的：从Nymphaea tetragona var。中分离出含有geraniin的辐射放射防护组合物。 提供angusta提取物级分以促进造血系统的保护和恢复并抑制氧化细胞损伤。 构成：辐射放射防护组合物含有0.001-10.0重量％的吉拉宁作为活性成分。 er in属从Nymphaea tetragona var。 angusta提取物级分。 分离geraniin的方法包括：制备Nymphaea tetragona var。 angusta为粉状，用蒸馏水悬浮; 用己烷，乙酰乙酸乙酯，丁醇和水分级的步骤; 用二氯甲烷，乙醚，乙酸乙酯和丙酮分馏的步骤; 和通过柱色谱法分离geraniin的步骤。
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公开(公告)号：KR1020170075062A
公开(公告)日：2017-07-03
申请号：KR1020150183597
申请日：2015-12-22
Applicant: 제주대학교 산학협력단
Abstract: 본발명은보리, 당근, 누룩, 생수를준비하고, 보리를세척한후 1.5배의물을넣어보리밥을짓고, 보리밥 30 ~ 40wt%, 누룩 1 ~ 5wt%, 생수 45 ~ 60wt%, 당근 5 ~ 20wt% 을혼합한후 25 ~ 35℃에서 24시간 ~ 72시간발효시키고, 발효물을필터링을하는단계를포함하는당근쉰다리제조방법을제공한다. 본발명에따르면, 발효과정에서도당근의색상이그대로유지되어심미감이우수하고, 주재료인보리의영양성분과발효를주도하는젖산균, 그리고부재료이지만당근의영양성분까지섭취할수 있어전통쉰다리의새로운이용가능성을기대할수 있다.
Abstract translation: 本发明大麦，胡萝卜，酵母，然后制备水，洗涤大麦到水的1.5倍来构建大麦，大麦30〜40重量％，酵母1〜5重量％，水45〜60重量％，胡萝卜5至 将发酵产物在25〜35℃发酵24〜72小时，过滤发酵产物。 根据本发明，胡萝卜的颜色保留在发酵过程中，美学yiwoosu，和乳酸，这导致了大麦中，主材料和副材料的营养分钟发酵，但有利的传统其余部分的新的可用性可消耗最多在胡萝卜营养素 我可以期待。
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公开(公告)号：KR101100126B1
公开(公告)日：2011-12-29
申请号：KR1020090043313
申请日：2009-05-19
Applicant: 제주대학교 산학협력단
Abstract: 본 발명은 수련 추출분획물에서 분리한 제라닌을 유효성분으로 함유하는 방사선 방호용 조성물에 관한 것이다.
본 발명의 제라닌(Geraniin)은, 수련(
Nymphaea tetragona )을 분말형태로 제조한 후, 이를 알코올로 추출한 다음 증류수로 현탁시킨 후, 헥산(Hexane), 에틸아세테이트(Ethyl acetate), 부탄올(Butanol), 물(Water)로 용매분획한 다음, 이 용매분획물들 중 에틸아세테이트 분획물을 다시 메틸렌클로라이드(Methylene chloride), 디에틸에테르(Diethyl ether), 에틸아세테이트(Ethyl acetate), 아세톤(acetone)으로 용매분획한 후, 얻어진 디에틸에테르 분획물을 컬럼크로마토그래피로 분획하여 획득하는 것으로 구성된다.
본 발명에 의해, 수련 추출분획물에서 분리되어 뛰어난 방사선 방호효과를 갖는 제라닌(Geraniin)을 유효성분으로 함유하는 방사선 방호용 조성물이 제공된다.
수련, 추출물, 제라닌, 방사선, 방호효과-
公开(公告)号：KR100791108B1
公开(公告)日：2008-01-03
申请号：KR1020060108652
申请日：2006-11-06
Applicant: 제주대학교 산학협력단
IPC: A61K36/185
Abstract: A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus is provided to be able to obtain the fraction which is able to inhibit the lymphocyte damage by the radioactive rays irradiation and the apoptosis of tissue cells. A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus comprises the steps of: (a) after drying branch of Elaeocarpus sylvestris var. ellipticus in the shade, finely cutting it to prepare Elaeocarpus sylvestris var. ellipticus finely cut materials; (b) after precipitating the prepared cut materials in 70% ethanol at a temperature of 20-25 deg.C for 20-24 hours, filtering it using a filtering device under reduced pressure to prepare an ethanol extract; (c) concentrating the ethanol extract under reduced pressure to prepare a concentrate solution; (d) after suspending the concentrate solution with distilled water and putting 0.5-2 liters of hexane in 1 liter of the suspension with agitation, separating a hexane layer using a separatory funnel to obtain the remaining water layer; (e) after putting 0.5-2 liters of ethylacetate in 1 liter of the water layer with agitation, separating an ethylacetate layer using a separatory funnel; (f) concentrating the ethylacetate layer under reduced pressure to prepare an ethylacetate concentrate solution; and (g) after mixing the ethylacetate concentrate solution with sellaite and charging a column with the mixture, obtaining an ethylacetate fraction using ethylacetate as a developing solvent and then concentrating the fraction to obtain the fraction concentrate of Elaeocarpus sylvestris var. ellipticus.
Abstract translation: 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 提供椭圆体以能够获得能够通过放射线照射和组织细胞凋亡抑制淋巴细胞损伤的级分。 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 椭圆形包括以下步骤：（a）干燥榆树的分枝后， 椭圆形在阴凉处，精细切割，准备榆树。 椭圆形细切材料; （b）在20-25℃的温度下将制备的切割材料在70％乙醇中沉淀20-24小时后，使用过滤装置在减压下过滤以制备乙醇提取物; （c）减压浓缩乙醇提取物以制备浓缩液; （d）用蒸馏水悬浮浓缩液后，在搅拌下将0.5-2升己烷置于1升悬浮液中，用分液漏斗分离己烷层，得到剩余的水层; （e）在搅拌下将0.5-2升乙酸乙酯置于1升水层中后，使用分液漏斗分离乙酸乙酯层; （f）减压浓缩乙酸乙酯层以制备乙酸乙酯浓缩液; 和（g）在将乙酸乙酯浓缩液与矾土混合并向混合物中加入柱子后，用乙酸乙酯作为展开溶剂获得乙酸乙酯部分，然后浓缩该级分以获得El the the the的级分浓缩物。 ellipticus。
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