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公开(公告)号：KR102053770B1
公开(公告)日：2019-12-09
申请号：KR1020170054358
申请日：2017-04-27
Applicant: 제주대학교 산학협력단
IPC: A01K67/027 , A61L31/04 , A61L31/14 , A61K49/00 , G01N33/50
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公开(公告)号：KR1020100124359A
公开(公告)日：2010-11-29
申请号：KR1020090043313
申请日：2009-05-19
Applicant: 제주대학교 산학협력단
CPC classification number: A61K31/7048 , A61K36/62 , A61K2236/33 , A61K2236/55 , Y10S514/917
Abstract: PURPOSE: A radiation radioprotective composition containing geraniin isolated from Nymphaea tetragona var. angusta extract fraction is provided to promote protection and recovery of hematopoietic system and to suppress oxidative cell damage. CONSTITUTION: A radiation radioprotective composition contains 0.001-10.0 weight% of geraniin as an active ingredient. The geraniin is isolated from Nymphaea tetragona var. angusta extract fraction. A method for isolating geraniin comprises: a step of preparing Nymphaea tetragona var. angusta in a powdery form and suspending with distilled water; a step of fractioning with hexane, ethyl acetoacetate, butanol, and water; a step of fractioning with methylene chloride, diethyl ether, ethyl acetate, and acetone; and a step of isolating geraniin by column chromatography.
Abstract translation: 目的：从Nymphaea tetragona var。中分离出含有geraniin的辐射放射防护组合物。 提供angusta提取物级分以促进造血系统的保护和恢复并抑制氧化细胞损伤。 构成：辐射放射防护组合物含有0.001-10.0重量％的吉拉宁作为活性成分。 er in属从Nymphaea tetragona var。 angusta提取物级分。 分离geraniin的方法包括：制备Nymphaea tetragona var。 angusta为粉状，用蒸馏水悬浮; 用己烷，乙酰乙酸乙酯，丁醇和水分级的步骤; 用二氯甲烷，乙醚，乙酸乙酯和丙酮分馏的步骤; 和通过柱色谱法分离geraniin的步骤。
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3.发明公开
公开(公告)号：KR1020120078863A
公开(公告)日：2012-07-11
申请号：KR1020110000152
申请日：2011-01-03
Applicant: 제주대학교 산학협력단
IPC: G21F1/10
Abstract: PURPOSE: A composition comprising an extract of polyopes lancifolia (Harvey) kawaguchi et wang as an active ingredient for protecting cells or tissues against radiation is provided to protect an organism from damage to cells or tissues. CONSTITUTION: A composition for protecting cells or tissues against radiation comprises an extract of polyopes lancifolia (Harvey) kawaguchi et wang as an active ingredient. The extract is extracted using water or organic solvents. The composition protects cells or tissues against radiation. The radiation is gamma-irradiation.
Abstract translation: 目的：提供一种组合物，其包含作为保护细胞或组织免受辐射的活性成分的聚对苯二甲酸甘油（Harvey）kawaguchi等人的提取物，以保护生物免受细胞或组织的损伤。 构成：用于保护细胞或组织免受辐射的组合物包括作为活性成分的聚对苯二甲酸甘油（Harvey）提取物。 萃取液用水或有机溶剂萃取。 组合物保护细胞或组织免受辐射。 辐射是γ射线。
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公开(公告)号：KR1020120015158A
公开(公告)日：2012-02-21
申请号：KR1020100077439
申请日：2010-08-11
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
IPC: C07D319/24 , A61K36/03 , A61K31/357 , A61P35/00
Abstract: PURPOSE: A radiation protective composition containing diphlorethohydroxycarmalol is provided to suppress cell apoptosis and to enhance hematogenesis and immunity. CONSTITUTION: A radiation protective composition contains DHPC(diphlorethohydroxycarmalol) of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is derived from Ishigeaceae plants. The composition also contains Ishigeaceae plant extract as an active ingredient. The Ishigeaceae plant is Ishige okamurae. The extract is prepared using water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylana chloride, n-hexane, acetic acid, formic acid, citric acid, or cyclo hexane.
Abstract translation: 目的：提供一种含有双轴羟基卡马洛的辐射防护组合物，以抑制细胞凋亡，增强血液发生和免疫。 构成：辐射防护组合物含有化学式1的DHPC（二
色柔和羟基卡马拉）或其药学上可接受的盐作为活性成分。 该化合物衍生自石ae科植物。 该组合物还含有菊科植物提取物作为活性成分。 石斛科植物是Ishige okamurae。 萃取液用水，甲醇，乙醇，丙醇，异丙醇，丁醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，甲基丙烯酰氯，正己烷，乙酸，甲酸，柠檬酸或环己烷制备。-
公开(公告)号：KR1020120131511A
公开(公告)日：2012-12-05
申请号：KR1020110049717
申请日：2011-05-25
Applicant: 제주대학교 산학협력단 , 재단법인 제주테크노파크
IPC: A61K31/357 , A61P1/16
Abstract: PURPOSE: A composition containing diphlorethohydroxycarmalol extracted from Ishige okamurae is provided to prevent and treat liver injury caused by carbon tetrachloride. CONSTITUTION: A composition for preventing or treating liver injury contains DPHC(diphlorethohydroxycarmalol) of chemical formula 1 or pharmaceutical acceptable salts thereof as an active ingredient. The compound is derived from Ishige okamurae plants. The composition for preventing or treating liver injury contains Ishige okamurae plant extract as an active ingredient. The extract is prepared using water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, acetic acid, formic acid, citric acid, diethyl ether, or cyclohexane. A functional food for preventing or treating liver injury contains DPHC or the extract containing the same as an active ingredient.
Abstract translation: 目的：提供一种含有从山茱萸提取的双色羟基卡马洛的组合物，用于预防和治疗四氯化碳引起的肝损伤。 构成：用于预防或治疗肝损伤的组合物含有化学式1的DPHC（二舒昔洛夫羟基卡马拉）或其药学上可接受的盐作为活性成分。 该化合物衍生自Ishige okamurae植物。 用于预防或治疗肝损伤的组合物含有植物提取物作为活性成分。 提取物用水，甲醇，乙醇，丙醇，异丙醇，丁醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，二氯甲烷，正己烷，盐酸，乙酸，甲酸，柠檬酸，乙醚， 或环己烷。 用于预防或治疗肝损伤的功能性食品含有DPHC或含有与活性成分相同的提取物。
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Patent Agency Ranking6.发明授权털지누아리 추출물을 유효성분으로 포함하는 방사선으로부터 세포나 조직 방호용 조성물 失效组合物包括用于保护细胞或组织免受辐射的Polyopes lancifolia Harvey kawaguchi et wang提取物
公开(公告)号：KR101191599B1
公开(公告)日：2012-10-15
申请号：KR1020110000152
申请日：2011-01-03
Applicant: 제주대학교 산학협력단
IPC: G21F1/10
Abstract: 본 발명은 방사선으로부터 세포나 조직을 방호하는 털지누아리(Polyopes lancifolia (Harvey) kawaguchi et wang)의 신규한 용도에 관한 것이다. 구체적으로 본 발명은 털지누아리 추출물을 유효성분으로 포함하는 방사선으로부터 세포나 조직 방호용 조성물에 관한 것이다. 상기 방사선에는 감마-조사(γ-irradiation)가 포함된다. 본 발명에 따른 털지누아리 추출물은 방사선 조사로 유발되는 활성산소종(ROS)의 생성을 억제하고, 항산화 효소들의 활성을 보존시킨다. 또한, 방사선 조사에 의한 세포사멸(apoptosis)을 효과적으로 억제할 수 있다. 따라서 방사선으로부터 생물체를 방호하는데 유용하게 사용될 수 있다.
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公开(公告)号：KR100791108B1
公开(公告)日：2008-01-03
申请号：KR1020060108652
申请日：2006-11-06
Applicant: 제주대학교 산학협력단
IPC: A61K36/185
Abstract: A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus is provided to be able to obtain the fraction which is able to inhibit the lymphocyte damage by the radioactive rays irradiation and the apoptosis of tissue cells. A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus comprises the steps of: (a) after drying branch of Elaeocarpus sylvestris var. ellipticus in the shade, finely cutting it to prepare Elaeocarpus sylvestris var. ellipticus finely cut materials; (b) after precipitating the prepared cut materials in 70% ethanol at a temperature of 20-25 deg.C for 20-24 hours, filtering it using a filtering device under reduced pressure to prepare an ethanol extract; (c) concentrating the ethanol extract under reduced pressure to prepare a concentrate solution; (d) after suspending the concentrate solution with distilled water and putting 0.5-2 liters of hexane in 1 liter of the suspension with agitation, separating a hexane layer using a separatory funnel to obtain the remaining water layer; (e) after putting 0.5-2 liters of ethylacetate in 1 liter of the water layer with agitation, separating an ethylacetate layer using a separatory funnel; (f) concentrating the ethylacetate layer under reduced pressure to prepare an ethylacetate concentrate solution; and (g) after mixing the ethylacetate concentrate solution with sellaite and charging a column with the mixture, obtaining an ethylacetate fraction using ethylacetate as a developing solvent and then concentrating the fraction to obtain the fraction concentrate of Elaeocarpus sylvestris var. ellipticus.
Abstract translation: 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 提供椭圆体以能够获得能够通过放射线照射和组织细胞凋亡抑制淋巴细胞损伤的级分。 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 椭圆形包括以下步骤：（a）干燥榆树的分枝后， 椭圆形在阴凉处，精细切割，准备榆树。 椭圆形细切材料; （b）在20-25℃的温度下将制备的切割材料在70％乙醇中沉淀20-24小时后，使用过滤装置在减压下过滤以制备乙醇提取物; （c）减压浓缩乙醇提取物以制备浓缩液; （d）用蒸馏水悬浮浓缩液后，在搅拌下将0.5-2升己烷置于1升悬浮液中，用分液漏斗分离己烷层，得到剩余的水层; （e）在搅拌下将0.5-2升乙酸乙酯置于1升水层中后，使用分液漏斗分离乙酸乙酯层; （f）减压浓缩乙酸乙酯层以制备乙酸乙酯浓缩液; 和（g）在将乙酸乙酯浓缩液与矾土混合并向混合物中加入柱子后，用乙酸乙酯作为展开溶剂获得乙酸乙酯部分，然后浓缩该级分以获得El the the the的级分浓缩物。 ellipticus。
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公开(公告)号：KR101100126B1
公开(公告)日：2011-12-29
申请号：KR1020090043313
申请日：2009-05-19
Applicant: 제주대학교 산학협력단
Abstract: 본 발명은 수련 추출분획물에서 분리한 제라닌을 유효성분으로 함유하는 방사선 방호용 조성물에 관한 것이다.
본 발명의 제라닌(Geraniin)은, 수련(
Nymphaea tetragona )을 분말형태로 제조한 후, 이를 알코올로 추출한 다음 증류수로 현탁시킨 후, 헥산(Hexane), 에틸아세테이트(Ethyl acetate), 부탄올(Butanol), 물(Water)로 용매분획한 다음, 이 용매분획물들 중 에틸아세테이트 분획물을 다시 메틸렌클로라이드(Methylene chloride), 디에틸에테르(Diethyl ether), 에틸아세테이트(Ethyl acetate), 아세톤(acetone)으로 용매분획한 후, 얻어진 디에틸에테르 분획물을 컬럼크로마토그래피로 분획하여 획득하는 것으로 구성된다.
본 발명에 의해, 수련 추출분획물에서 분리되어 뛰어난 방사선 방호효과를 갖는 제라닌(Geraniin)을 유효성분으로 함유하는 방사선 방호용 조성물이 제공된다.
수련, 추출물, 제라닌, 방사선, 방호효과-
公开(公告)号：KR1020100002528A
公开(公告)日：2010-01-07
申请号：KR1020080062451
申请日：2008-06-30
Applicant: 제주대학교 산학협력단
IPC: A61K36/282 , A61K31/7034
CPC classification number: A61K36/282 , A23L29/035 , A61K8/602 , A61K8/97 , A61K31/7034 , A61K2236/33 , A61K2236/55
Abstract: PURPOSE: An Artemisia iwayomogi extract fraction composition containing annphenone is provided to suppress ROS generation and enhance antioxidase activation. CONSTITUTION: A method for preparing Artemisia iwayomogi extract fraction composition comprises: a step of extracting the Artemisia iwayomogi with methanol and extracting with hexane and water; a step of fractioning with chloroform, ethylacetate, and butanol; a step of fractioning the ethylacetate fraction through chromatography; and a step of purifying the fraction with hexane to obtain the Artemisia iwayomogi extract fraction composition. A food additive, beverage composition, functional health food or cosmetic composition contains the Artemisia iwayomogi extract fraction composition.
Abstract translation: 目的：提供含有苯乙酮的青蒿提取物组分，以抑制ROS的产生并增强抗氧化酶活性。 构成：制备蒿木提取物组分的方法包括：用甲醇萃取青蒿素并用己烷和水萃取的步骤; 用氯仿，乙酸乙酯和丁醇分级的步骤; 通过色谱分离乙酸乙酯级分的步骤; 和用己烷纯化该级分以获得蒿木蒿提取物组分的步骤。 食品添加剂，饮料组合物，功能保健食品或化妆品组合物含有蒿蒿提取物组分。
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公开(公告)号：KR101007515B1
公开(公告)日：2011-01-14
申请号：KR1020080062451
申请日：2008-06-30
Applicant: 제주대학교 산학협력단
IPC: A61K36/282 , A61K31/7034
Abstract: 본 발명은 안페논(Annphenone)이 함유된 더위지기 추출분획조성물에 관한 것이다.
본 발명의 안페논(Annphenone)이 함유된 더위지기 추출분획조성물은 더위지기(
Artemisia
iwayomogi )을 메탄올로 추출하고, 이 메탄올 추출물을 헥산과 물로 분배추출한 후, 분리된 물층에 극성이 다른 용매인 클로로포름과 에틸아세테이트, 부탄올을 넣고 순차적으로 분배추출하여 용매분획물을 제조한 후, 그 중 에틸아세테이트 분획물을 크로마토그래피를 이용하여 분획하고, 이 분획물을 헥산으로 정제하여 제조된다.
본 발명에 의해 항산화효과 및 세포보호효과를 갖는 안페논(Annphenone) 성분이 함유된 더위지기 추출분획조성물이 제공된다.
안페논, 더위지기, 항산화, 세포보호, 활성산소종, 아폽토시스
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