公开(公告)号：KR100791108B1

公开(公告)日：2008-01-03

申请号：KR1020060108652

申请日：2006-11-06

Applicant: 제주대학교 산학협력단

Inventor： 이남호 ,  지영흔 ,  박은진 ,  백종석 ,  박재우 ,  신태균 ,  현진원 ,  주홍구

IPC: A61K36/185

Abstract: A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus is provided to be able to obtain the fraction which is able to inhibit the lymphocyte damage by the radioactive rays irradiation and the apoptosis of tissue cells. A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus comprises the steps of: (a) after drying branch of Elaeocarpus sylvestris var. ellipticus in the shade, finely cutting it to prepare Elaeocarpus sylvestris var. ellipticus finely cut materials; (b) after precipitating the prepared cut materials in 70% ethanol at a temperature of 20-25 deg.C for 20-24 hours, filtering it using a filtering device under reduced pressure to prepare an ethanol extract; (c) concentrating the ethanol extract under reduced pressure to prepare a concentrate solution; (d) after suspending the concentrate solution with distilled water and putting 0.5-2 liters of hexane in 1 liter of the suspension with agitation, separating a hexane layer using a separatory funnel to obtain the remaining water layer; (e) after putting 0.5-2 liters of ethylacetate in 1 liter of the water layer with agitation, separating an ethylacetate layer using a separatory funnel; (f) concentrating the ethylacetate layer under reduced pressure to prepare an ethylacetate concentrate solution; and (g) after mixing the ethylacetate concentrate solution with sellaite and charging a column with the mixture, obtaining an ethylacetate fraction using ethylacetate as a developing solvent and then concentrating the fraction to obtain the fraction concentrate of Elaeocarpus sylvestris var. ellipticus.

Abstract translation: 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 提供椭圆体以能够获得能够通过放射线照射和组织细胞凋亡抑制淋巴细胞损伤的级分。 一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法 椭圆形包括以下步骤：（a）干燥榆树的分枝后， 椭圆形在阴凉处，精细切割，准备榆树。 椭圆形细切材料; （b）在20-25℃的温度下将制备的切割材料在70％乙醇中沉淀20-24小时后，使用过滤装置在减压下过滤以制备乙醇提取物; （c）减压浓缩乙醇提取物以制备浓缩液; （d）用蒸馏水悬浮浓缩液后，在搅拌下将0.5-2升己烷置于1升悬浮液中，用分液漏斗分离己烷层，得到剩余的水层; （e）在搅拌下将0.5-2升乙酸乙酯置于1升水层中后，使用分液漏斗分离乙酸乙酯层; （f）减压浓缩乙酸乙酯层以制备乙酸乙酯浓缩液; 和（g）在将乙酸乙酯浓缩液与矾土混合并向混合物中加入柱子后，用乙酸乙酯作为展开溶剂获得乙酸乙酯部分，然后浓缩该级分以获得El the the the的级分浓缩物。 ellipticus。

公开(公告)号：KR1020120015158A

公开(公告)日：2012-02-21

申请号：KR1020100077439

申请日：2010-08-11

Applicant: 제주대학교 산학협력단 ,  재단법인 제주테크노파크

Inventor： 신태균 ,  현진원 ,  주홍구 ,  지영흔 ,  박재우 ,  이남호 ,  양원준 ,  안미정 ,  고려경 ,  김기옥

IPC: C07D319/24 ,  A61K36/03 ,  A61K31/357 ,  A61P35/00

Abstract: PURPOSE: A radiation protective composition containing diphlorethohydroxycarmalol is provided to suppress cell apoptosis and to enhance hematogenesis and immunity. CONSTITUTION: A radiation protective composition contains DHPC(diphlorethohydroxycarmalol) of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is derived from Ishigeaceae plants. The composition also contains Ishigeaceae plant extract as an active ingredient. The Ishigeaceae plant is Ishige okamurae. The extract is prepared using water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylana chloride, n-hexane, acetic acid, formic acid, citric acid, or cyclo hexane.

Abstract translation: 目的：提供一种含有双轴羟基卡马洛的辐射防护组合物，以抑制细胞凋亡，增强血液发生和免疫。 构成：辐射防护组合物含有化学式1的DHPC（二
色柔和羟基卡马拉）或其药学上可接受的盐作为活性成分。 该化合物衍生自石ae科植物。 该组合物还含有菊科植物提取物作为活性成分。 石斛科植物是Ishige okamurae。 萃取液用水，甲醇，乙醇，丙醇，异丙醇，丁醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，甲基丙烯酰氯，正己烷，乙酸，甲酸，柠檬酸或环己烷制备。

公开(公告)号：KR1020160011952A

公开(公告)日：2016-02-02

申请号：KR1020140093298

申请日：2014-07-23

Applicant: 제주대학교 산학협력단

Inventor： 주홍구 ,  장지영

IPC: A23L1/30 ,  A23K1/16 ,  A61K31/737

CPC classification number: A23L33/10 ,  A23K20/00 ,  A61K31/737 ,  C08B37/0063

Abstract: 분자량이서로다른후코이단은면역세포의생존율과면역기능에차별된효과를나타내며, 특히본 발명에따른고분자후코이단은비장세포의생존율, 세포활성자극, CD19, CD25 또는 CD69 발현, 세포내 미토콘드리아의막전위수준, IFN-γ및 NO의생산을증대함으로써비장세포에대한강력한면역자극활성을나타냄을확인하였으므로면역증강용식품, 동물사료첨가조성물로사용할수 있다.

Abstract translation: 本发明涉及具有增加含有岩藻依聚糖的脾细胞的存活力和功能的作用的免疫增强组合物。 具有差异分子量的岩藻依聚糖对免疫细胞的存活率和免疫功能具有不同的影响。 特别地，通过增加脾细胞的存活率，刺激细胞活性，CD19，CD25或CD69的表达，证实本发明的聚合物岩藻依聚糖表现出对脾细胞的功能免疫刺激活性，膜电位 细胞内线粒体和IFN-γ和NO的产生，因此可以用作免疫增强的食物和动物饲料添加剂组合物。

公开(公告)号：KR100791100B1

公开(公告)日：2008-01-04

申请号：KR1020070001206

申请日：2007-01-05

Applicant: 제주대학교 산학협력단

Inventor： 신태균 ,  주홍구 ,  지영흔 ,  박재우 ,  현진원 ,  이남호 ,  이지영 ,  김미형

IPC: A61K31/737

CPC classification number: A61K31/737 ,  A61K2121/00 ,  Y10S514/917

Abstract: A radiation protective composition comprising fucoidan is provided to protect the radiation excellently, thereby preventing the decrease of circulatory leukocyte count and the death of bone marrow cells in accordance with the application of the radiation. A composition for protecting radiation comprises fucoidan which is prepared by dissolving fucoidan in phosphate buffer saline(PBS) as an effective ingredient, wherein the 1-10mg of fucoidan is dissolved in 1ml of the PBS.

Abstract translation: 提供包含岩藻依聚糖的辐射防护组合物以保护辐射，从而根据辐射的应用防止循环白细胞计数减少和骨髓细胞死亡。 用于保护辐射的组合物包括通过将岩藻依聚糖溶解在磷酸盐缓冲盐水（PBS）中作为有效成分制备的岩藻依聚糖，其中将1-10mg岩藻依聚糖溶解在1ml PBS中。

公开(公告)号：KR101635268B1

公开(公告)日：2016-06-30

申请号：KR1020140093298

申请日：2014-07-23

Applicant: 제주대학교 산학협력단

Inventor： 주홍구 ,  장지영

IPC: A23L1/30 ,  A23K1/16 ,  A61K31/737

Abstract: 분자량이서로다른후코이단은면역세포의생존율과면역기능에차별된효과를나타내며, 특히본 발명에따른고분자후코이단은비장세포의생존율, 세포활성자극, CD19, CD25 또는 CD69 발현, 세포내 미토콘드리아의막전위수준, IFN-γ및 NO의생산을증대함으로써비장세포에대한강력한면역자극활성을나타냄을확인하였으므로면역증강용식품, 동물사료첨가조성물로사용할수 있다.

公开(公告)号：KR1020100058141A

公开(公告)日：2010-06-03

申请号：KR1020080116857

申请日：2008-11-24

Applicant: 제주대학교 산학협력단

Inventor： 임윤규 ,  주홍구 ,  황규계

IPC: A61K39/245 ,  A61K39/395 ,  A61P37/00

CPC classification number: A61K39/27 ,  A61K9/0019 ,  A61K49/16

Abstract: PURPOSE: A horse herpesvirus vaccine formulation targeting Fc receptor of dendritic cells is provided to effectively enhance horse immunity. CONSTITUTION: An EHV-1(equine Herpesvirus-1) vaccine formulation contains a fusion protein as an active ingredient, in which inactivated EHV-1 and immunoglobulin heavy chain constant region are conjugated by covalent bond. The inactivated EHV-1 is obtained using ethylene imine, derivative of ethylene imine, beta-propiolactone, aldehyde compound, formalin, phenol, hypochlorite, or detergent. The EHV-1 vaccine formulation additionally contains an adjuvant. The vaccine formulation is used for injection.

Abstract translation: 目的：提供靶向树突细胞Fc受体的马疱疹病毒疫苗制剂，以有效增强马的免疫力。 构成：EHV-1（马疱疹病毒-1）疫苗制剂含有融合蛋白作为活性成分，其中灭活的EHV-1和免疫球蛋白重链恒定区通过共价键共轭。 使用乙烯亚胺，乙烯亚胺衍生物，β-丙内酯，醛化合物，福尔马林，苯酚，次氯酸盐或洗涤剂得到灭活的EHV-1。 EHV-1疫苗制剂另外含有佐剂。 疫苗制剂用于注射。