公开(公告)号：KR1020130068307A

公开(公告)日：2013-06-26

申请号：KR1020110135340

申请日：2011-12-15

Applicant: 조선대학교산학협력단

Inventor： 최철희 ,  조훈 ,  샌딮카나 ,  문영숙 ,  김권천 ,  최은서

IPC: A61K36/47 ,  A61K36/54 ,  A61K36/60 ,  A61P17/14

Abstract: PURPOSE: A composition containing a plant extract for suppressing 15-hydroxyprostaglandin dehydrogenase(15-PGDH) is provided to effectively suppress 15-PGDH which is a core material for inactivation of PGE2 with low cytotoxicity. CONSTITUTION: A composition for preventing or treating alopecia contains one or more plant extracts selected from the group consisting of Glochidion hirsulta, Glochidion velutinum, Cinnamomum tetragonum, Memecylon edule, Artocarpus hetrophyllus, Allospondias lakonensis, Commersonia batramia, Syzygium bullockii aff., Syzygium formosum, Choerospondias axillaris, Lumnitzera racemosa, Osbeckia stellata, Trema orientalis, Lithocarpus gymnocarpus, Planchonella obovata, Triumfetta grandidens, Triumfetta bartramia, Mallotus apelta, Baccaurea ramiflora, and Sonneratia alba. The composition is manufactured in the form of a tablet, a pill, a powder, a granule, a capsule, a troch, or a drink. The composition is a parenteral formulation such as an external use formulation or a sterile injection solvent. [Reference numerals] (AA) Example 2; (BB) Example 4; (CC) Example 6; (DD) Example 7; (EE) Example 8; (FF) Example 9; (GG) Example 10

Abstract translation: 目的：提供含有用于抑制15-羟基前列腺素脱氢酶（15-PGDH）的植物提取物的组合物，以有效抑制作为细胞毒性低的PGE2失活的核心材料的15-PGDH。 构成：用于预防或治疗秃发的组合物含有一种或多种选自下列组的植物提取物：山茱萸（Glochidion hirsulta），卷心菜（Cinucomum tetragonum），梅花科植物（Memecylon edule），黑叶草（Artocarpus hetrophyllus），白僵菌（Allospondias lakonensis），巴斯克氏菌（Commersonia batramia） Choerospondias axillaris，Lumnitzera racemosa，Osbeckia stellata，Trema orientalis，Lithocarpus gymnocarpus，Planchonella obovata，Triumfetta grandidens，Triumfetta bartramia，Mallotus apelta，Baccaurea ramiflora和Sonneratia alba。 组合物以片剂，丸剂，粉剂，颗粒剂，胶囊剂，troch或饮料的形式制备。 组合物是胃肠外制剂，例如外用制剂或无菌注射溶剂。 （附图标记）（AA）实施例2 （BB）实施例4 （CC）实施例6; （DD）实施例7; （EE）实施例8; （FF）实施例9; （GG）实施例10