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公开(公告)号：KR1020130103945A
公开(公告)日：2013-09-25
申请号：KR1020120024994
申请日：2012-03-12
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A flavone compound is provided to increase PGE2 in cells with less cytotoxicity and to enable effective wound healing, thereby being used as an active ingredient of a composition and a cosmetic composition for preventing and treating diseases which need the increase of PGE2. CONSTITUTION: A pharmaceutical composition for preventing and treating diseases which need the increase of PEG2, such as inflammatory diseases, tumor, Alzheimer's disease, and atherosclerosis contains a compound of chemical formula 1 as an active ingredient. The compound of chemical formula 1 suppresses 15-hydroxyprostaglandin dehydrogenase (15-hydroxy PGDH) and increases PGE2. A cosmetic composition for improving scalp and skin regeneration contains the compound of chemical formula 1 as an active ingredient.
Abstract translation: 目的：提供黄酮化合物以增加细胞毒性的细胞中的PGE2，并且能够有效地伤口愈合，由此用作组合物的活性成分和用于预防和治疗需要增加PGE2的疾病的化妆品组合物。 构成：用于预防和治疗需要增加PEG2的疾病如炎性疾病，肿瘤，阿尔茨海默氏病和动脉粥样硬化的药物组合物含有化学式1化合物作为活性成分。 化学式1的化合物抑制15-羟基前列腺素脱氢酶（15-羟基PGDH）并增加PGE2。 用于改善头皮和皮肤再生的化妆品组合物含有化学式1的化合物作为活性成分。
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公开(公告)号：KR101370670B1
公开(公告)日：2014-03-06
申请号：KR1020120024994
申请日：2012-03-12
Applicant: 조선대학교산학협력단
Abstract: 본 발명은 플라본 화합물을 유효성분으로 함유하는 PGE
2 증가를 필요로 하는 질환의 예방 및 치료용 조성물, 탈모, 두피 개선 및 피부 재생용 화장료 조성물, 및 피부 미용 조성물에 관한 것으로, 더욱 구체적으로는 본 발명의 7, 3', 4'-트리메톡시플라본은 세포독성이 적으며, PGE
2 를 대사시키는 효소인 15-PGDH를 효과적으로 억제하고, 상처 치유에 관련된 PGE
2 의 세포 내외의 수준을 조절하는 분자인 COX-1/2, MRP4 및 PGT의 mRNA 발현을 조절하여 세포 내외의 PGE
2
수준을 조절하여 상처 치유능을 향상시키고 PGE
2 증가와 관련된 질환을 치료하는 효과를 가짐으로써 PGE
2 증가를 필요로 하는 질환의 예방 및 치료용 조성물, 탈모, 두피 개선 및 피부 재생용 화장료 조성물, 및 피부 미용 조성물의 유효성분으로 유용하게 사용될 수 있다.-
3.发明公开
公开(公告)号：KR1020130068307A
公开(公告)日：2013-06-26
申请号：KR1020110135340
申请日：2011-12-15
Applicant: 조선대학교산학협력단
Abstract: PURPOSE: A composition containing a plant extract for suppressing 15-hydroxyprostaglandin dehydrogenase(15-PGDH) is provided to effectively suppress 15-PGDH which is a core material for inactivation of PGE2 with low cytotoxicity. CONSTITUTION: A composition for preventing or treating alopecia contains one or more plant extracts selected from the group consisting of Glochidion hirsulta, Glochidion velutinum, Cinnamomum tetragonum, Memecylon edule, Artocarpus hetrophyllus, Allospondias lakonensis, Commersonia batramia, Syzygium bullockii aff., Syzygium formosum, Choerospondias axillaris, Lumnitzera racemosa, Osbeckia stellata, Trema orientalis, Lithocarpus gymnocarpus, Planchonella obovata, Triumfetta grandidens, Triumfetta bartramia, Mallotus apelta, Baccaurea ramiflora, and Sonneratia alba. The composition is manufactured in the form of a tablet, a pill, a powder, a granule, a capsule, a troch, or a drink. The composition is a parenteral formulation such as an external use formulation or a sterile injection solvent. [Reference numerals] (AA) Example 2; (BB) Example 4; (CC) Example 6; (DD) Example 7; (EE) Example 8; (FF) Example 9; (GG) Example 10
Abstract translation: 目的：提供含有用于抑制15-羟基前列腺素脱氢酶（15-PGDH）的植物提取物的组合物，以有效抑制作为细胞毒性低的PGE2失活的核心材料的15-PGDH。 构成：用于预防或治疗秃发的组合物含有一种或多种选自下列组的植物提取物：山茱萸（Glochidion hirsulta），卷心菜（Cinucomum tetragonum），梅花科植物（Memecylon edule），黑叶草（Artocarpus hetrophyllus），白僵菌（Allospondias lakonensis），巴斯克氏菌（Commersonia batramia） Choerospondias axillaris，Lumnitzera racemosa，Osbeckia stellata，Trema orientalis，Lithocarpus gymnocarpus，Planchonella obovata，Triumfetta grandidens，Triumfetta bartramia，Mallotus apelta，Baccaurea ramiflora和Sonneratia alba。 组合物以片剂，丸剂，粉剂，颗粒剂，胶囊剂，troch或饮料的形式制备。 组合物是胃肠外制剂，例如外用制剂或无菌注射溶剂。 （附图标记）（AA）实施例2 （BB）实施例4 （CC）实施例6; （DD）实施例7; （EE）实施例8; （FF）实施例9; （GG）实施例10
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