公开(公告)号：KR1020080061611A

公开(公告)日：2008-07-03

申请号：KR1020060136535

申请日：2006-12-28

Applicant: 주식회사농심

Inventor： 송인상 ,  박창신 ,  안창원 ,  강주희 ,  이호현 ,  한기선

IPC: C12P21/06

CPC classification number: C12P21/06 ,  C12N1/20 ,  C12N9/0083 ,  C12Y114/99003

Abstract: A soybean protein hydrolysate is provided to induce expression of heme oxygenase-1(HO-1), protect cells by effects of HO-1 including anti-inflammation, cell proliferation and apoptosis inhibition, and protect and treat vascular damage shown in obesity, hypertension, impotence, dysuria, diabetes, arthritis and aging. A soybean protein hydrolysate for increasing expression of heme oxygenase-1 is prepared by hydrolyzing soybeans with endopeptidase and exopeptidase, or fermenting soybeans with a microorganism selected from Bacillus sp., Leuconostoc sp., Lactobacillus sp. and Aspergillus sp., separating the hydrolyzed or fermented solution into a solid phase and a liquid phase, and filtering and powdering the liquid phase, wherein the soybean is black soybean; the microorganism is Bacillus subtilis(KCTC 11029BP); and the soybean protein hydrolysate activate Co-cGMP(cyclic guanosine mono-phosphate) pathway.

Abstract translation: 提供大豆蛋白水解物以诱导血红素加氧酶-1（HO-1）的表达，通过HO-1的作用保护细胞，包括抗炎，细胞增殖和凋亡抑制，并保护和治疗肥胖，高血压中显示的血管损伤 ，无能，排尿困难，糖尿病，关节炎和衰老。 通过用内肽酶和外肽酶水解大豆，或用选自芽孢杆菌（Bacillus sp。），明串珠菌（Leuconostoc sp。），乳杆菌属（Lactobacillus sp。））的微生物发酵大豆来制备用于增加血红素加氧酶-1表达的大豆蛋白水解产物。 和曲霉菌，将水解或发酵的溶液分离成固相和液相，过滤和粉化液相，其中大豆是黑豆; 该微生物是枯草芽孢杆菌（KCTC 11029BP）; 大豆蛋白水解物活化Co-cGMP（环鸟苷酸一磷酸）途径。