中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.02 seconds)

    신규 아클라비논 유도체 및 그의 제조방법
    3.
    发明公开
    신규 아클라비논 유도체 및 그의 제조방법 失效
    新型AKLAVINONE衍生物及其生产方法

    公开(公告)号：KR1020000067074A

    公开(公告)日：2000-11-15

    申请号：KR1019990014564

    申请日：1999-04-23

    Applicant: 한국과학기술연구원 ,  일동홀딩스(주)

    Inventor： 김기원 ,  김태용 ,  이홍섭 ,  강대중 ,  이정준 ,  김항섭 ,  홍영수

    IPC: C07C69/757 ,  C12N15/00

    Abstract: PURPOSE: Novel aklavinone derivatives prepared by transforming biosynthetic variants with a vector containing aklavinone C-11 hydroxylase gene separated from Streptomyces sp and fermenting transformer thereof and process for producing the same are provided which can be effectively used for an antibiotic. CONSTITUTION: 2,11-Dihydroxyaklavinone of formula 1 is used in the manufacture of various new anthracycline antibiotics through bioconversion. Thus, 2,11-dihydroxyaklavinonecycline as anthracycline antibiotics is prepared by using the compound as a precursor, has low toxicity against a cell and is safer than conventional antibiotics.

    Abstract translation: 目的：提供通过用链霉菌sp和发酵变压器分离的含有aklavinone C-11羟化酶基因的载体转化生物合成变体制备的新型aklavinone衍生物及其生产方法，其可有效用于抗生素。 构成：式1的2,11-二羟基喹喔啉通过生物转化用于制备各种新的蒽环类抗生素。 因此，通过使用该化合物作为前体制备作为蒽环类抗生素的2,11-二羟基喹诺酮类，对细胞毒性低，比常规抗生素更安全。

    생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
    4.
    发明公开
    생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법 有权
    用于标记生物分子的新型氰胺化合物及其制备方法

    公开(公告)号：KR1020100115301A

    公开(公告)日：2010-10-27

    申请号：KR1020100030228

    申请日：2010-04-02

    Applicant: (주)바이오액츠 ,  한국과학기술연구원

    Inventor： 김동진 ,  김영수 ,  나종주 ,  박진우 ,  김기원

    IPC: C07D403/02 ,  C07D209/04

    CPC classification number: C07D403/06 ,  C07D209/08

    Abstract: PURPOSE: A novel cyanine compound for labeling molecule and method for preparing the same are provided to ensure high stability without additional purification. CONSTITUTION: A novel cyanine compound for labeling molecules is denoted by chemical formula 1. The compound has fluorescence at 500-800 nm wave length. The compound is labeled with bio molecule, nanoparticles or organic compound containing amine group, hydroxyl group, or thiol group. A method for preparing the compound of chemical formula 1 comprises: a step of reacting a compound of chemical formula 4 with a compound of chemical formula 5 or 7 to obtain a compound of chemical formula 6a; a step of reacting the compound of chemical formula 6a with a compound of chemical formula 8 to obtain a compound of chemical formula 9; a step of reacting the compound of chemical formula 9 with a compound of chemical formula 6b to obtain a compound of chemical formula 10; a step of reacting the compound of chemical formula 10 with 1,1'-carbonyldiimidazole or N,N-disuccineimidyl carbonate to obtain a compound of chemical formula 11a or 11b; and a step of reacting the compound of chemical formula 11a or 11b with a compound of chemical formula 12 under the presence of Hunig base.

    Abstract translation: 目的：提供用于标记分子的新颖花青化合物及其制备方法，以确保高稳定性而无需额外纯化。 构成：化学式1表示用于标记分子的新型花青化合物。化合物在500-800nm波长处具有荧光。 该化合物用生物分子，纳米颗粒或含有胺基，羟基或硫醇基的有机化合物进行标记。 制备化学式1的化合物的方法包括：使化学式4的化合物与化学式5或7的化合物反应以获得化学式6a的化合物的步骤; 使化学式6a的化合物与化学式8的化合物反应，得到化学式9的化合物的工序; 使化学式9的化合物与化学式6b的化合物反应，得到化学式10的化合物的工序; 使化学式10的化合物与1,1'-羰基二咪唑或N，N-二琥珀酰亚胺基碳酸酯反应，得到化学式11a或11b的化合物的步骤; 以及使化学式11a或11b的化合物与化学式12的化合物在Hunig碱的存在下反应的步骤。

    ＬＴＣＣ를 이용한 복합후각센서 및 그 제조방법
    5.
    发明授权
    ＬＴＣＣ를 이용한 복합후각센서 및 그 제조방법 失效
    LTCC适用于所有的应用程序

    公开(公告)号：KR100655367B1

    公开(公告)日：2006-12-08

    申请号：KR1020050062344

    申请日：2005-07-11

    Applicant: 한국과학기술연구원

    Inventor： 강종윤 ,  윤석진 ,  김진상 ,  이종흔 ,  조평석 ,  김기원

    IPC: G01N37/00

    Abstract: A multi-olfactory sensor using LTCC(Low Temperature Co-fired Ceramic) and a manufacturing method are provided to effectively detect the compound chemical amount and to produce the multi-olfactory sensors at low cost by pattern recognition. The multi-olfactory sensor using LTCC comprises plural unit olfactory sensors. The unit olfactory sensor is composed of a first dense LTCC layer; a heater(50) formed on the first dense LTCC layer; a second dense LTCC layer formed on the first dense LTCC layer and the heater; an electrode pattern(60) formed on the second dense LTCC layer; a third dense LTCC layer disposed on the second dense LTCC layer and the electrode pattern; a pair of sensitive electrodes(80) arranged on the third dense LTCC layer; a connecting electrode(70) connecting the electrode pattern and a pair of sensitive electrodes; a fourth dense LTCC layer(40) formed on the third dense LTCC layer and provided with an opening exposing the sensitive electrodes; and a sensitive material part formed on the third dense LTCC layer in the opening to come into contact with a pair of sensitive electrodes. The sensitive material part is formed by loading sensitive materials(90) changing a resistance value between the sensitive electrodes according to external chemical materials, to the sensitive electrodes and drying the sensitive materials.

    Abstract translation: 提供使用LTCC（低温共烧陶瓷）的多嗅觉传感器和制造方法，以有效检测化合物的化学量并通过模式识别以低成本生产多嗅觉传感器。 使用LTCC的多嗅觉传感器包括多个单元嗅觉传感器。 单元嗅觉传感器由第一密集LTCC层组成; 形成在第一致密LTCC层上的加热器（50） 在第一致密LTCC层和加热器上形成的第二致密LTCC层; 在第二致密LTCC层上形成的电极图案（60） 设置在所述第二致密LTCC层和所述电极图案上的第三致密LTCC层; 布置在第三致密LTCC层上的一对敏感电极（80） 连接电极图案和一对敏感电极的连接电极（70） 形成在所述第三致密LTCC层上并且设置有暴露所述敏感电极的开口的第四致密LTCC层（40） 以及在开口中的第三致密LTCC层上形成的敏感材料部分，以与一对敏感电极接触。 敏感材料部分是通过加载敏感材料（90）来形成的，敏感材料（90）根据外部化学材料改变敏感电极之间的电阻值，敏感电极和干燥敏感材料。

    신규 아클라비논 유도체 및 그의 제조방법
    6.
    发明授权
    신규 아클라비논 유도체 및 그의 제조방법 失效
    新型氨氯因酮衍生物及其制备方法

    公开(公告)号：KR100343394B1

    公开(公告)日：2002-07-15

    申请号：KR1019990014564

    申请日：1999-04-23

    Applicant: 한국과학기술연구원 ,  일동홀딩스(주)

    Inventor： 김기원 ,  김태용 ,  이홍섭 ,  강대중 ,  이정준 ,  김항섭 ,  홍영수

    IPC: C07C69/757 ,  C12N15/00

    Abstract: 본발명은신규아클라비논유도체와미생물을이용한제조방법, 그리고상기화합물의제조에이용되는형질전환체에관한것으로, 보다상세하게는스트렙토마이세스속 균주로부터분리된아클라비논 C-11 히드록실라제유전자를포함하는벡터로생합성변이주를형질전환시킨다음, 그형질전환체를배양하여하기화학식 1의신규아클라비논유도체인 2,11-디히드록시아클라비논을제조하는데, 상기화합물은새로운안트라사이클린계항생물질을제조하기위한전구체로사용될수 있으며, 생물전환의방법으로얻어지는안트라사이클린계항생제는세포독성이낮아부작용이적은효과적인항생제로이용될수 있다.

Patent Agency Ranking